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vTv Therapeutics Announces Publication of Comprehensive Data in Science Translational Medicine Detailing the Discovery and Clinical Development of TTP399, including Results of Phase 2 AGATA Study
Results Found TTP399 Demonstrated a Statistically Significant Improvement in HbA1c Compared to Placebo without Hypoglycemia or Hyperlipidemia
In this 6-month study, TTP399 (800 mg/day) was associated with a statistically significant and sustained reduction in glycated hemoglobin, with a placebo-subtracted least squares mean HbA1c change from baseline of −0.9% (p< 0.01). Compared to placebo, TTP399 (800 mg/day) also increased high-density lipoprotein cholesterol (3.2 mg/dl; p< 0.05), decreased fasting plasma glucagon (−20 pg/ml; p< 0.05). Moreover, in patients weighing ≥100 kg, TTP399 decreased weight (−3.4 kg; p< 0.05) compared to placebo. No hypoglycemia, no detrimental effects on plasma lipids or liver enzymes, and no increased blood pressure were observed with TTP399 relative to placebo, highlighting the importance of tissue selectivity and preservation of physiological regulation when targeting key metabolic regulators such as GK.
“We are very pleased with the positive results of the AGATA study. Building on the success seen in type 2 diabetes, we are also currently conducting an adaptive phase 2 study in collaboration with the JDRF in subjects with type 1 diabetes and expect to release results from part 1 of the study later this year. This paper is a testament to the excellent pre-clinical and clinical capabilities of our researchers who were able to translate their deep understanding of GK biology into a promising clinical drug candidate,” commented Steve Holcombe, president and CEO of vTv Therapeutics.
“Due to its unique properties, TTP399 has overcome a significant
historical challenge in the development of GK activation,” said Dr.
The publication, titled “Targeting Hepatic Glucokinase to Treat Diabetes with TTP399, a Hepatoselective Glucokinase Activator”, is published in the latest edition of the peer-reviewed journal Science Translational Medicine and can be found at http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aau3441.
GK is a genetically validated target in the development of diabetes, making it an attractive therapeutic target. However, the use of GK as a therapeutic target for the treatment of type 2 diabetes has been historically limited by hypoglycemia, steatohepatitis, and loss of efficacy over time.
The clinical characteristics of patients with GK-activating mutations or GK regulatory protein (GKRP) loss-of-function indicated that a hepatoselective GK activator (GKA) that does not activate GK in beta cells or affect the GK-GKRP interaction may reduce hyperglycemia in patients with type 2 diabetes, while limiting hypoglycemia and liver-associated adverse effects.
Using its proprietary drug discovery platform, vTv identified and characterized small-molecule compounds, including TTP399, with the ability to increase GK activity in the liver without affecting the physiological role of GK.
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