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vTv Therapeutics to Present a Poster at the American Diabetes Association’s 78th Scientific Sessions
Details of the presentations are listed below:
Late-Breaking Poster Title: “Simplici-T1 First Clinical Trial to
Test Activation of Glucokinase as an Adjunctive Treatment for Type 1
Poster Number: 126-LB
Category: 12-E Clinical Therapeutics/New Technology–Oral Agents
Date and Time: Monday, June 25, 2018, 12-
“As the first company to evaluate a Glucokinase Activator in people with type 1 diabetes, we are very excited to be sharing this clinical data at the American Diabetes Association’s 78th Scientific Sessions,” said Carmen Valcarce, Ph.D., executive vice president, chief scientific officer, vTv Therapeutics. “TTP399 was well tolerated in this small, open label, study in patients with type 1 diabetes and showed trends towards improving glycemic control while reducing insulin dose. Following these encouraging data, we are now evaluating TTP399 in a 12-week randomized, placebo-controlled, phase 2 study in type 1 diabetes to evaluate safety and efficacy”.
Simplici-T1 is a multi-center, randomized, double-blind, adaptive study assessing the pharmacokinetics, pharmacodynamics, safety and tolerability of TTP399 in adult patients with type 1 diabetes (T1D). This study is being conducted in two phases: Phase 1 evaluated the safety of ascending TTP399 dosage regimens in five patients each over one week of daily dosing; Phase 2 will evaluate the safety and efficacy of a TTP399 dosing regimen over twelve weeks of daily dosing. This study is being conducted with support from JDRF, the leading global organization funding T1D research.
About Type 1 Diabetes
Type 1 diabetes is an autoimmune disease in which a person’s pancreas stops producing insulin, a hormone that enables people to get energy from food. It occurs when the body’s immune system attacks and destroys the insulin-producing cells in the pancreas, called beta cells. While its causes are not yet entirely understood, scientists believe that both genetic factors and environmental triggers are involved. Its onset has nothing to do with diet or lifestyle. There is nothing you can do to prevent T1D, and—at present—nothing you can do to cure it.
vTv Therapeutics Inc. is a clinical-stage biopharmaceutical company engaged in the discovery and development of orally administered small molecule drug candidates to fill significant unmet medical needs. vTv has a pipeline of clinical drug candidates led by programs for the treatment of Alzheimer’s disease and diabetes as well as treatment of inflammatory disorders.
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