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|vTv Therapeutics Announces Positive Topline Results from Phase 2 Study of TTP273 in Type 2 Diabetes|
Oral small molecule GLP-1 receptor agonist met primary endpoint
Company’s second successful Phase 2 diabetes trial in 2016
“It is remarkable to see an oral small molecule therapy that
demonstrates similar benefits of the injectable diabetes GLP1 drugs
without the commonly associated side effects of nausea and vomiting,”
said David D’Alessio, M.D., Professor,
In the 12-week study conducted in 30 centers in
“TTP273 is the first and only oral small molecule GLP-1R agonist in
clinical development. These positive data further validate our novel
approach to drug discovery,” said
TTP273 is an oral small molecule that works by activating the GLP-1 receptor. Activation of the GLP-1 receptor leads to the enhancement of insulin secretion and suppression of glucagon production and decreased food intake.
There are currently several marketed injectable GLP-1 therapies. These agents have demonstrated notable glucose lowering in addition to weight loss; however, their widespread use may be hindered by the route of administration (injection) and by the high incidence of gastrointestinal side effects (nausea and vomiting).
About Type 2 Diabetes
Type 2 diabetes is a result of the body’s inability to use insulin
properly to control sugar in the bloodstream. Type 2 diabetes represents
up to 95% of diabetes patients, imposing a growing burden on healthcare
systems globally. Diabetes remains the 7th leading cause of death in
About vTv Therapeutics
vTv Therapeutics Inc. is a clinical-stage biopharmaceutical company engaged in the discovery and development of orally administered small molecule drug candidates to fill significant unmet medical needs. vTv has a pipeline of clinical drug candidates led by programs for the treatment of Alzheimer’s disease and Type 2 diabetes, as well as treatment of inflammatory disorders and the prevention of muscle weakness.
vTv is also pursuing the clinical development of TTP399, a novel liver selective Glucokinase Activator (GKA) with first-in-class potential for the treatment of Type 2 diabetes. vTv recently announced positive top line results from the six-month Phase 2b AGATA Study in subjects with Type 2 diabetes.
The company's Alzheimer’s disease drug candidate, azeliragon, is a novel oral small molecule antagonist of the Receptor for Advance Glycation Endproducts (RAGE) with first-in-class potential. The azeliragon development program has been granted Fast Track Designation and agreement on its Phase 3 protocol has been reached with FDA via a Special Protocol Assessment (SPA). Enrollment of part A of the Phase 3 STEADFAST study in patients with mild Alzheimer's disease was completed during the third quarter, and topline data from this part of the study is anticipated to be reported in early 2018.
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