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|vTv Therapeutics to Present Two Posters at the 2017 Alzheimer's Association International Conference|
Details of the poster presentations are listed below:
Poster Title: “Assessment of Azeliragon QTc Liability through
Integrated, Model-Based Concentration QTc Analysis”
Poster Title: “Effect of Food on the Pharmacokinetics of
Azeliragon in Healthy Adult Subjects”
Azeliragon, also known as TTP488, is a novel orally active small-molecule antagonist of RAGE. A broad range of human pathologic and experimental biologic investigation suggests that RAGE activation contributes to the pathogenesis of Alzheimer’s disease. Sustained Amyloid-β interactions with RAGE at the blood-brain barrier (BBB) and in neuronal and microglial cells, play potentially major roles in amyloid plaque formation, neuroinflammation and chronic neural dysfunction – all hallmarks of Alzheimer’s disease.
About vTv Therapeutics
vTv Therapeutics Inc. is a clinical-stage biopharmaceutical company engaged in the discovery and development of orally administered small molecule drug candidates to fill significant unmet medical needs. vTv has a pipeline of clinical drug candidates led by programs for the treatment of Alzheimer’s disease and Type 2 diabetes as well as treatment of inflammatory disorders and the prevention of muscle weakness.
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