|New Pre-Clinical Data on a vTv Therapeutics Small Molecule Drug Candidate Against Parkinson’s Disease to be Presented at the Society for Neuroscience 2016 Meeting in San Diego|
vTv has identified novel non-electrophilic Nrf2/Bach1 modulators that can activate nuclear factor-E2 related factor (“Nrf2”) and inhibit Bach1 (the Antioxidant Response Element (“ARE”) transcriptional repressor) leading to potent activation of the Nrf2 pathway. The results from the laboratory of Dr. Thomas suggest (1) Bach1 may be a promising novel target for drug development against Parkinson's disease, and (2) vTv's compound, HPPE, may protect against nigrostriatal dopaminergic neurodegeneration by virtue of its ability to activate neuroprotective Nrf2/ARE genetic response in a preclinical mouse model of Parkinson's disease.
Based on recent findings, aberrant oxidative stress and inflammation play a key role in the pathogenesis of PD and preclinical studies suggest that activating the Nrf2/Bach1 pathway could have disease modifying effects on PD. Current pharmacological approaches targeting the Nrf2 pathway presents safety and tolerability issues as these pharmacophores contain reactive electrophilic groups.
Parkinson's disease is a progressive and debilitating neurodegenerative movement disorder characterized by marked nigrostriatal dopaminergic cell loss in the brain. No preventive therapy or cure is yet available for PD.
Dr. Thomas will be available to discuss the findings at the
The company's Alzheimer’s disease drug candidate, azeliragon, is a novel oral small molecule antagonist of the Receptor for Advance Glycation Endproducts (RAGE) with first-in-class potential.
The azeliragon development program has been granted Fast Track
Designation and agreement on its Phase 3 protocol has been reached with
vTv is also pursuing the clinical development of TTP399, a novel liver selective Glucokinase Activator (GKA) with first-in-class potential for the treatment of type 2 diabetes. The company recently announced positive top line results from the six month phase 2b AGATA Study in subjects with type 2 diabetes.
vTv’s second diabetes drug candidate, TTP273, is an oral, small molecule GLP-1R agonist with best-in-class potential. The company reported the completion of enrollment of the three month Phase 2 LOGRA study in the third quarter with data readout expected at the end of 2016. The previous Phase 1b trial of TTP273 demonstrated robust effects on postprandial and fasting glucose. All doses of TTP273 were well tolerated with no serious adverse events or evidence of gastrointestinal side effects compared to placebo.
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