|vTv Therapeutics Presents Data Highlighting Further Potential of TTP273 at American Diabetes Association 77th Scientific Sessions|
Lower doses of TTP273 may demonstrate a more pronounced reduction in HbA1c and other key endpoints
In a poster presentation titled, “Is Less More? Learning to dose the oral, non-peptide GLP-1R Agonist, TTP273 in Type 2 Diabetics,” researchers from vTv reviewed results from a concentration/effect analysis on the LOGRA study showing that lower doses of TTP273 may show more pronounced effects for key efficacy endpoints, including a reduction in HbA1c, weight and fasting plasma glucose. The characteristics of TTP273 (functionally biased and neuro-endocrine signaling) provide a potential scientific rationale supporting the concept that for TTP273, less may be more.
“Further analysis of the Phase 2 data has highlighted a trend where a
lower dose shows more pronounced effects,” said
TTP273-201 is a 12-week, multi-center Phase 2, double-blind, placebo-controlled randomized study of 174 patients with Type 2 diabetes on stable doses of metformin who were randomized to either placebo or TTP273 (150 mg once (QPM) or twice (BID) daily). Baseline characteristics were well balanced amongst groups with an overall mean age of 56 years, mean HbA1c of 8.6% and mean BMI of 32 kg/m2. TTP273 was well tolerated with no severe hypoglycemia adverse events (AEs). The most common TEAE was diarrhea, mostly mild in intensity, with only one subject discontinued due to mild diarrhea (150 mg BID). Less nausea was observed in active groups than placebo and the only incidence of vomiting occurred with placebo dosing. Once daily dosing of TTP273 demonstrated placebo-subtracted decrease from baseline of 0.9% in HbA1c and 0.9 kg in weight.
A copy of the presentation will be made available in the News & Events section of the Company’s website following the presentation.
TTP273 is an oral small molecule that works by activating the GLP-1 receptor. Activation of the GLP-1 receptor leads to the enhancement of insulin secretion and suppression of glucagon production and decreased food intake.
There are currently several marketed injectable GLP-1 therapies. These agents have demonstrated notable glucose lowering in addition to weight loss; however, their widespread use may be hindered by the route of administration (injection) and by the high incidence of gastrointestinal side effects (nausea and vomiting).
About Type 2 Diabetes
Type 2 diabetes is a result of the body’s inability to use insulin
properly to control sugar in the bloodstream. Type 2 diabetes represents
up to 95% of diabetes patients, imposing a growing burden on healthcare
systems globally. Diabetes remains the 7th leading cause of death in the
The Company’s drug candidates were discovered with its high-throughput drug discovery platform, TTP Translational Technology®, which translates the functional modulation of human proteins into safe and effective medicines. For further company information, visit www.vtvtherapeutics.com.
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