United States securities and exchange commission logo December 2, 2020 Stephen L. Holcombe President and Chief Executive Officer vTv Therapeutics Inc. 3980 Premier Drive, Suite 310 High Point, NC 27265 Re: vTv Therapeutics Inc. Registration Statement on Form S-1 Filed November 24, 2020 File No. 333-250934 Dear Mr. Holcombe: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Deanna Virginio at 202-551-4530 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Ray Russo, Esq.