United States securities and exchange commission logo

                 June 8, 2021

       Stephen L. Holcombe
       President and Chief Executive Officer
       vTv Therapeutics Inc.
       3980 Premier Drive, Suite 310
       High Point, NC 27265

                                                        Re: vTv Therapeutics
Statement on Form S-3
                                                            Filed June 3, 2021
                                                            File No. 333-256755

       Dear Mr. Holcombe:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

              Please contact Fredrick Philantrope at 202-551-6875 or Alan
Campbell at 202-551-4224
       with any questions.


                 Division of Corporation Finance

                 Office of Life Sciences
       cc:                                              Lawrence G. Wee, Esq.