<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:cc23dfa8-b7f1-4dd2-bc21-5440216f3885,g:7d227720-4a1d-461e-9922-f5c0b011aa4f-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/Cover" xlink:type="simple" xlink:href="vtvt-20220630.xsd#Cover"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_a5ffd0ee-867a-4cc9-9410-855fb46a5239" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_d70b2040-775d-4acf-9f8b-4a0e6711cf8e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentInformationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a5ffd0ee-867a-4cc9-9410-855fb46a5239" xlink:to="loc_dei_DocumentInformationTable_d70b2040-775d-4acf-9f8b-4a0e6711cf8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_bb5d4813-b9e8-4407-bfdc-31ec2d455a76" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_d70b2040-775d-4acf-9f8b-4a0e6711cf8e" xlink:to="loc_us-gaap_StatementClassOfStockAxis_bb5d4813-b9e8-4407-bfdc-31ec2d455a76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_41ce70a3-1a14-44c7-adc3-4292da995d26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_bb5d4813-b9e8-4407-bfdc-31ec2d455a76" xlink:to="loc_us-gaap_ClassOfStockDomain_41ce70a3-1a14-44c7-adc3-4292da995d26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_3414846c-f9b2-45ef-8c49-735fbbd4ed86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_41ce70a3-1a14-44c7-adc3-4292da995d26" xlink:to="loc_us-gaap_CommonClassAMember_3414846c-f9b2-45ef-8c49-735fbbd4ed86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_515a3840-018b-4e05-9ad2-4c4321a4d3c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_41ce70a3-1a14-44c7-adc3-4292da995d26" xlink:to="loc_us-gaap_CommonClassBMember_515a3840-018b-4e05-9ad2-4c4321a4d3c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_d70b2040-775d-4acf-9f8b-4a0e6711cf8e" xlink:to="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_4e20ab18-4278-4982-bdc1-fac20d512ee3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_DocumentType_4e20ab18-4278-4982-bdc1-fac20d512ee3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_8232ac77-c42b-441b-afc7-646ac8445473" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentQuarterlyReport"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_DocumentQuarterlyReport_8232ac77-c42b-441b-afc7-646ac8445473" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_bd2f89c3-4fda-4b1e-b0d6-50b9cd2ca3ed" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_DocumentPeriodEndDate_bd2f89c3-4fda-4b1e-b0d6-50b9cd2ca3ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_0b78e376-cc55-42c9-a568-74ea79ec72e2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_DocumentTransitionReport_0b78e376-cc55-42c9-a568-74ea79ec72e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_fb578304-21d4-4a4f-be74-8f43b4b49f09" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityFileNumber_fb578304-21d4-4a4f-be74-8f43b4b49f09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_d08856f5-a3ec-49d1-aa4b-7a17debc9ff7" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityRegistrantName_d08856f5-a3ec-49d1-aa4b-7a17debc9ff7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_52b6ec30-d3f2-4498-bac0-c803a4064369" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityIncorporationStateCountryCode_52b6ec30-d3f2-4498-bac0-c803a4064369" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_96aed983-8256-42b8-8566-4ee9706b0bf7" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityTaxIdentificationNumber_96aed983-8256-42b8-8566-4ee9706b0bf7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_76884ef0-bb21-490e-869d-b12c99e9939c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityAddressAddressLine1_76884ef0-bb21-490e-869d-b12c99e9939c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_8a1b781d-f357-4a21-8c68-d6ac3ec63aec" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityAddressAddressLine2_8a1b781d-f357-4a21-8c68-d6ac3ec63aec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_0074c0f7-d888-4abc-9429-a9686a7f37de" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityAddressCityOrTown_0074c0f7-d888-4abc-9429-a9686a7f37de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_7c769f5e-78d5-4eab-8687-2140749dd9de" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityAddressStateOrProvince_7c769f5e-78d5-4eab-8687-2140749dd9de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_d6b81078-c70e-4563-a688-e39869c54424" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityAddressPostalZipCode_d6b81078-c70e-4563-a688-e39869c54424" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_d5b85ef1-ad92-425d-80ec-e9a558696fd5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_CityAreaCode_d5b85ef1-ad92-425d-80ec-e9a558696fd5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_81903d33-fdab-439e-b614-40db6a5b053f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_LocalPhoneNumber_81903d33-fdab-439e-b614-40db6a5b053f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_cda7b855-cb67-4f7c-a750-317327badce6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_Security12bTitle_cda7b855-cb67-4f7c-a750-317327badce6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_242dfe2e-216a-463a-8f7e-ea515525b081" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_TradingSymbol_242dfe2e-216a-463a-8f7e-ea515525b081" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_98967ec6-da87-4d9e-b52f-c9e6df6b0ed9" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_SecurityExchangeName_98967ec6-da87-4d9e-b52f-c9e6df6b0ed9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_ca77e674-0f44-4e78-bde7-abaec7ffcb0b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityCurrentReportingStatus_ca77e674-0f44-4e78-bde7-abaec7ffcb0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_42d6809f-1d81-49cf-bd1f-dd1a3da4c7ad" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityInteractiveDataCurrent_42d6809f-1d81-49cf-bd1f-dd1a3da4c7ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_bff164a9-181f-4fe5-b11d-bb0551b34962" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityFilerCategory_bff164a9-181f-4fe5-b11d-bb0551b34962" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_73ba8a35-c5f8-469f-830d-2d548de1b206" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntitySmallBusiness_73ba8a35-c5f8-469f-830d-2d548de1b206" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_abe90b82-bdbf-41d2-a6a8-11c1cdfca3fa" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityEmergingGrowthCompany_abe90b82-bdbf-41d2-a6a8-11c1cdfca3fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_b9a742b1-d359-4f77-9f47-16d3d676e0c1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityShellCompany_b9a742b1-d359-4f77-9f47-16d3d676e0c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_6f2f14fe-881c-4444-bea3-8c8edb0381a6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_6f2f14fe-881c-4444-bea3-8c8edb0381a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_ac3bf5f8-646e-4861-b297-b29c6d73bd79" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_EntityCentralIndexKey_ac3bf5f8-646e-4861-b297-b29c6d73bd79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_c7597602-1946-40c6-b29e-9fdf77da68c0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_CurrentFiscalYearEndDate_c7597602-1946-40c6-b29e-9fdf77da68c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_4ffdc1b2-7d11-4d25-9153-c984bad2a44c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_DocumentFiscalYearFocus_4ffdc1b2-7d11-4d25-9153-c984bad2a44c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_d313d770-dfb2-4f06-b30e-f47a87a87be0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_DocumentFiscalPeriodFocus_d313d770-dfb2-4f06-b30e-f47a87a87be0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_9d306df2-f2d8-4555-a2ee-69a72286420f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_8484d455-867a-47f8-ac0e-92246ef19e35" xlink:to="loc_dei_AmendmentFlag_9d306df2-f2d8-4555-a2ee-69a72286420f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_2cb2ed45-d750-49f8-96fc-7cd0c1a586e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_3559e17f-f682-4eda-8f47-cb42940b81eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_2cb2ed45-d750-49f8-96fc-7cd0c1a586e8" xlink:to="loc_us-gaap_StatementTable_3559e17f-f682-4eda-8f47-cb42940b81eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_7869bf40-b6a4-4788-a172-5054adff2a5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_3559e17f-f682-4eda-8f47-cb42940b81eb" xlink:to="loc_us-gaap_StatementClassOfStockAxis_7869bf40-b6a4-4788-a172-5054adff2a5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_dd07da80-9a63-47d7-8c5c-01a4ac911e31" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_7869bf40-b6a4-4788-a172-5054adff2a5c" xlink:to="loc_us-gaap_ClassOfStockDomain_dd07da80-9a63-47d7-8c5c-01a4ac911e31" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_54d5c9a9-e8eb-44c7-b42e-a903e68a0c2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_dd07da80-9a63-47d7-8c5c-01a4ac911e31" xlink:to="loc_us-gaap_CommonClassAMember_54d5c9a9-e8eb-44c7-b42e-a903e68a0c2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_04639c79-10e6-42fa-b8a5-283066899ae3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_dd07da80-9a63-47d7-8c5c-01a4ac911e31" xlink:to="loc_us-gaap_CommonClassBMember_04639c79-10e6-42fa-b8a5-283066899ae3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_df6e6dbb-6d7c-46c1-98af-f34d3adf6986" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_3559e17f-f682-4eda-8f47-cb42940b81eb" xlink:to="loc_us-gaap_StatementLineItems_df6e6dbb-6d7c-46c1-98af-f34d3adf6986" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_74fe96ed-9f9c-4818-8c7a-eb7c044ad4cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_df6e6dbb-6d7c-46c1-98af-f34d3adf6986" xlink:to="loc_us-gaap_AssetsAbstract_74fe96ed-9f9c-4818-8c7a-eb7c044ad4cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_1252ea6f-5352-437c-982e-6b34cf8ac967" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_74fe96ed-9f9c-4818-8c7a-eb7c044ad4cb" xlink:to="loc_us-gaap_AssetsCurrentAbstract_1252ea6f-5352-437c-982e-6b34cf8ac967" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_14fc2c84-19d3-4a25-8621-c27a3c81d271" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_1252ea6f-5352-437c-982e-6b34cf8ac967" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_14fc2c84-19d3-4a25-8621-c27a3c81d271" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_172e6996-6e26-4796-bbdd-2f4e20f63949" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_1252ea6f-5352-437c-982e-6b34cf8ac967" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_172e6996-6e26-4796-bbdd-2f4e20f63949" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_NotesReceivableCurrent_0ab3636e-ccaf-4bea-8e42-3886e1e60d0d" xlink:href="vtvt-20220630.xsd#vtvt_NotesReceivableCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_1252ea6f-5352-437c-982e-6b34cf8ac967" xlink:to="loc_vtvt_NotesReceivableCurrent_0ab3636e-ccaf-4bea-8e42-3886e1e60d0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_af235a7c-62dd-468f-b83b-ff341b3e93c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_1252ea6f-5352-437c-982e-6b34cf8ac967" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_af235a7c-62dd-468f-b83b-ff341b3e93c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsAssetsCurrent_47feda78-1c48-4ce6-9092-77b98a36bb64" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsAssetsCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_1252ea6f-5352-437c-982e-6b34cf8ac967" xlink:to="loc_us-gaap_DepositsAssetsCurrent_47feda78-1c48-4ce6-9092-77b98a36bb64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_34cebba3-0819-4c2a-9325-62c876d7ece3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_1252ea6f-5352-437c-982e-6b34cf8ac967" xlink:to="loc_us-gaap_AssetsCurrent_34cebba3-0819-4c2a-9325-62c876d7ece3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_d9fbd1a2-09dd-485d-85f2-e4131414b269" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_74fe96ed-9f9c-4818-8c7a-eb7c044ad4cb" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_d9fbd1a2-09dd-485d-85f2-e4131414b269" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_e5c4c00f-5557-4f11-9405-a7bf443862cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_74fe96ed-9f9c-4818-8c7a-eb7c044ad4cb" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_e5c4c00f-5557-4f11-9405-a7bf443862cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_e1fa79ca-819e-4eea-a328-453bc939c865" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermInvestments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_74fe96ed-9f9c-4818-8c7a-eb7c044ad4cb" xlink:to="loc_us-gaap_LongTermInvestments_e1fa79ca-819e-4eea-a328-453bc939c865" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_f1d5c0b0-5d52-4ce4-8044-0585f6a8b01b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_74fe96ed-9f9c-4818-8c7a-eb7c044ad4cb" xlink:to="loc_us-gaap_Assets_f1d5c0b0-5d52-4ce4-8044-0585f6a8b01b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_df6e6dbb-6d7c-46c1-98af-f34d3adf6986" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_2a790b28-b3e1-4854-97e7-6e854981e0cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_2a790b28-b3e1-4854-97e7-6e854981e0cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_d6532965-2d30-4174-828a-58860fd188e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_2a790b28-b3e1-4854-97e7-6e854981e0cd" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_d6532965-2d30-4174-828a-58860fd188e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_90b9eb41-ec5c-4105-a12a-4a59f7354df6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_2a790b28-b3e1-4854-97e7-6e854981e0cd" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_90b9eb41-ec5c-4105-a12a-4a59f7354df6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_eabec723-3b2d-41af-ad3c-3aa137ecfdf3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_2a790b28-b3e1-4854-97e7-6e854981e0cd" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_eabec723-3b2d-41af-ad3c-3aa137ecfdf3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableCurrent_0c40fe75-5635-498b-a7c8-57deb91aeb1e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesPayableCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_2a790b28-b3e1-4854-97e7-6e854981e0cd" xlink:to="loc_us-gaap_NotesPayableCurrent_0c40fe75-5635-498b-a7c8-57deb91aeb1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_af235486-712a-4359-940f-882a033ca8e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_2a790b28-b3e1-4854-97e7-6e854981e0cd" xlink:to="loc_us-gaap_LiabilitiesCurrent_af235486-712a-4359-940f-882a033ca8e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_e4774554-7bb4-4cd3-843c-14fcc9e35a24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_e4774554-7bb4-4cd3-843c-14fcc9e35a24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_4732506a-9d9f-4117-9c78-ae7f1e607e98" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_4732506a-9d9f-4117-9c78-ae7f1e607e98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DueToRelatedPartiesNoncurrent_380e55ac-7983-448e-a7be-41fe3b9d9f28" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DueToRelatedPartiesNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:to="loc_us-gaap_DueToRelatedPartiesNoncurrent_380e55ac-7983-448e-a7be-41fe3b9d9f28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_8491ae90-f826-4128-a2ba-5e5f3726e165" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:to="loc_us-gaap_Liabilities_8491ae90-f826-4128-a2ba-5e5f3726e165" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_8dbccc85-1e45-406b-8ee2-d5dc55fbb833" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:to="loc_us-gaap_CommitmentsAndContingencies_8dbccc85-1e45-406b-8ee2-d5dc55fbb833" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount_757b7654-de93-48d9-aa6b-f2a45bdffbfa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:to="loc_us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount_757b7654-de93-48d9-aa6b-f2a45bdffbfa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract_cf59fc5f-8f26-46b2-9275-9f5550a24199" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:to="loc_us-gaap_StockholdersEquityAbstract_cf59fc5f-8f26-46b2-9275-9f5550a24199" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_6facb381-21e6-414f-a2e1-20196db3c7cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_cf59fc5f-8f26-46b2-9275-9f5550a24199" xlink:to="loc_us-gaap_CommonStockValue_6facb381-21e6-414f-a2e1-20196db3c7cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_2114c815-3993-46f9-835d-8eb576890d54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_cf59fc5f-8f26-46b2-9275-9f5550a24199" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_2114c815-3993-46f9-835d-8eb576890d54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_9690faa9-3dcc-4bea-ad11-735bb7473f8d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_cf59fc5f-8f26-46b2-9275-9f5550a24199" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_9690faa9-3dcc-4bea-ad11-735bb7473f8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_4c543526-fce0-4793-83f5-7876a8e8b7c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:to="loc_us-gaap_StockholdersEquity_4c543526-fce0-4793-83f5-7876a8e8b7c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_cf1c2408-9e03-49a5-9dfa-a4e51e3795ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_52209a0f-7b49-40a5-87ed-18a9ec2524a2" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_cf1c2408-9e03-49a5-9dfa-a4e51e3795ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CondensedConsolidatedBalanceSheetsParenthetical"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_8526239f-fae3-4805-8474-2c87c4714d51" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_77301ac8-84c5-4d70-ac51-f0e07850c5b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_8526239f-fae3-4805-8474-2c87c4714d51" xlink:to="loc_us-gaap_StatementTable_77301ac8-84c5-4d70-ac51-f0e07850c5b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_30df2bfe-f54e-43cc-bd93-ec0cfa2e9a83" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_77301ac8-84c5-4d70-ac51-f0e07850c5b2" xlink:to="loc_us-gaap_StatementClassOfStockAxis_30df2bfe-f54e-43cc-bd93-ec0cfa2e9a83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_063a17cd-1c71-4e38-8086-da43c551f5e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_30df2bfe-f54e-43cc-bd93-ec0cfa2e9a83" xlink:to="loc_us-gaap_ClassOfStockDomain_063a17cd-1c71-4e38-8086-da43c551f5e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_073a0f12-da46-4204-966d-0d8fe05223d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_063a17cd-1c71-4e38-8086-da43c551f5e9" xlink:to="loc_us-gaap_CommonClassAMember_073a0f12-da46-4204-966d-0d8fe05223d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_b3536a87-0a3d-47e9-a1e3-30eb06962f23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_063a17cd-1c71-4e38-8086-da43c551f5e9" xlink:to="loc_us-gaap_CommonClassBMember_b3536a87-0a3d-47e9-a1e3-30eb06962f23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_b8bfc31c-44a7-4a66-a2e2-987b605222dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_77301ac8-84c5-4d70-ac51-f0e07850c5b2" xlink:to="loc_us-gaap_StatementLineItems_b8bfc31c-44a7-4a66-a2e2-987b605222dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_28399485-e028-4e51-bcec-6f0d590721f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_b8bfc31c-44a7-4a66-a2e2-987b605222dd" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_28399485-e028-4e51-bcec-6f0d590721f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_4f8cb49c-e970-4418-9e46-6fb38bbe5f83" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_b8bfc31c-44a7-4a66-a2e2-987b605222dd" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_4f8cb49c-e970-4418-9e46-6fb38bbe5f83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_565c110b-afdd-4a88-a173-f896d3b7a362" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_b8bfc31c-44a7-4a66-a2e2-987b605222dd" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_565c110b-afdd-4a88-a173-f896d3b7a362" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CondensedConsolidatedStatementsofOperationsUnaudited" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CondensedConsolidatedStatementsofOperationsUnaudited"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CondensedConsolidatedStatementsofOperationsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_b6382e33-a2ad-4055-9dba-3fd27ca0ea06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_2d025a46-3b34-4fb5-8d2d-1a7bd6005c09" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_b6382e33-a2ad-4055-9dba-3fd27ca0ea06" xlink:to="loc_us-gaap_StatementTable_2d025a46-3b34-4fb5-8d2d-1a7bd6005c09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_a9d1fa73-ac65-456b-a0e9-85b12d36fe1c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_2d025a46-3b34-4fb5-8d2d-1a7bd6005c09" xlink:to="loc_us-gaap_StatementClassOfStockAxis_a9d1fa73-ac65-456b-a0e9-85b12d36fe1c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_f5172277-abf8-416f-a745-6bda0d76fd7a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_a9d1fa73-ac65-456b-a0e9-85b12d36fe1c" xlink:to="loc_us-gaap_ClassOfStockDomain_f5172277-abf8-416f-a745-6bda0d76fd7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_0a4be754-1057-48f9-b3b0-7d7f50144bb0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_f5172277-abf8-416f-a745-6bda0d76fd7a" xlink:to="loc_us-gaap_CommonClassAMember_0a4be754-1057-48f9-b3b0-7d7f50144bb0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_2d025a46-3b34-4fb5-8d2d-1a7bd6005c09" xlink:to="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a8a407d7-b3fe-4c72-9888-8b0f0dda12c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a8a407d7-b3fe-4c72-9888-8b0f0dda12c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_198ca204-6e68-4763-9aa2-f11d98bdfc82" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_OperatingExpensesAbstract_198ca204-6e68-4763-9aa2-f11d98bdfc82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_b7d25411-0deb-428d-9553-a26a12f879be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_198ca204-6e68-4763-9aa2-f11d98bdfc82" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_b7d25411-0deb-428d-9553-a26a12f879be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_f1a4c044-6c35-4919-99bd-96570f6ce140" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_198ca204-6e68-4763-9aa2-f11d98bdfc82" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_f1a4c044-6c35-4919-99bd-96570f6ce140" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_e0420687-73a1-4234-9a6a-4a0ffdf2318d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_198ca204-6e68-4763-9aa2-f11d98bdfc82" xlink:to="loc_us-gaap_OperatingExpenses_e0420687-73a1-4234-9a6a-4a0ffdf2318d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_90805be8-7057-4cd7-bea5-2b8e667ebd9d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_OperatingIncomeLoss_90805be8-7057-4cd7-bea5-2b8e667ebd9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_f9530602-edf5-446a-b70b-cb2e154b4b1b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_f9530602-edf5-446a-b70b-cb2e154b4b1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_OtherIncomeExpensesRelatedParty_ac5b6938-58a8-4a10-b569-6b203b42185c" xlink:href="vtvt-20220630.xsd#vtvt_OtherIncomeExpensesRelatedParty"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_vtvt_OtherIncomeExpensesRelatedParty_ac5b6938-58a8-4a10-b569-6b203b42185c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_40fabf91-22b3-489f-9b1f-005590112470" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_InvestmentIncomeInterest_40fabf91-22b3-489f-9b1f-005590112470" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_2c17dd4d-d344-412f-8402-b537c9ece91d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_InterestExpense_2c17dd4d-d344-412f-8402-b537c9ece91d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_8b74b577-eb80-4b0e-8b67-3c68d6bcfc62" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_8b74b577-eb80-4b0e-8b67-3c68d6bcfc62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_3c9f6862-6caa-4844-b24d-fe4031ab75f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_3c9f6862-6caa-4844-b24d-fe4031ab75f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_187b7aaf-8034-4464-8e9c-8187b1f76600" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_ProfitLoss_187b7aaf-8034-4464-8e9c-8187b1f76600" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_645ca932-8b59-4799-b715-5dc2cf9438c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_645ca932-8b59-4799-b715-5dc2cf9438c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_002e589b-4c8c-4576-9e89-f9c39d0ec31e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_NetIncomeLoss_002e589b-4c8c-4576-9e89-f9c39d0ec31e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_4413300e-2f85-4c40-868f-de2ea477c6c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_4413300e-2f85-4c40-868f-de2ea477c6c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_9e96325a-469b-457e-a53e-af3fd0acc1b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_EarningsPerShareBasic_9e96325a-469b-457e-a53e-af3fd0acc1b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_8ce17aeb-6bc0-4f33-9a4e-20ed2bee9d84" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_EarningsPerShareDiluted_8ce17aeb-6bc0-4f33-9a4e-20ed2bee9d84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_bec3c74d-6cd6-451c-a890-921232846b23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_bec3c74d-6cd6-451c-a890-921232846b23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_61192ca1-43eb-4056-9ceb-2c844adefaef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_49a19cae-5c27-4db4-b5c0-ce9efd91263f" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_61192ca1-43eb-4056-9ceb-2c844adefaef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CondensedConsolidatedStatementofChangesinRedeemableNoncontrollingInterestandStockholdersDeficitUnaudited" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CondensedConsolidatedStatementofChangesinRedeemableNoncontrollingInterestandStockholdersDeficitUnaudited"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CondensedConsolidatedStatementofChangesinRedeemableNoncontrollingInterestandStockholdersDeficitUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_736cda59-de06-4891-ae8e-d51f420a2d1b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_bf4f7a14-e1c3-42e7-9e5b-2e5f31fbcade" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_736cda59-de06-4891-ae8e-d51f420a2d1b" xlink:to="loc_us-gaap_StatementTable_bf4f7a14-e1c3-42e7-9e5b-2e5f31fbcade" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_fbd6cf1f-36e1-419d-b2fb-1440ea40374b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_bf4f7a14-e1c3-42e7-9e5b-2e5f31fbcade" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_fbd6cf1f-36e1-419d-b2fb-1440ea40374b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_6c000890-4445-43d5-9bba-ad62912270c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_fbd6cf1f-36e1-419d-b2fb-1440ea40374b" xlink:to="loc_us-gaap_EquityComponentDomain_6c000890-4445-43d5-9bba-ad62912270c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestMember_9b98afaa-4ebc-49fa-b1b8-7d16b80dec77" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncontrollingInterestMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_6c000890-4445-43d5-9bba-ad62912270c7" xlink:to="loc_us-gaap_NoncontrollingInterestMember_9b98afaa-4ebc-49fa-b1b8-7d16b80dec77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_e3f16137-49a2-4318-a9ce-7906effc96d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_6c000890-4445-43d5-9bba-ad62912270c7" xlink:to="loc_us-gaap_CommonStockMember_e3f16137-49a2-4318-a9ce-7906effc96d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_dda83cbb-eba0-4d99-b6de-6338956e3233" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_6c000890-4445-43d5-9bba-ad62912270c7" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_dda83cbb-eba0-4d99-b6de-6338956e3233" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_1d3838aa-3fcb-40ca-8769-4b3a16a0ec07" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_6c000890-4445-43d5-9bba-ad62912270c7" xlink:to="loc_us-gaap_RetainedEarningsMember_1d3838aa-3fcb-40ca-8769-4b3a16a0ec07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_7c37e679-73dc-4b40-a2a6-6946c91f0722" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_bf4f7a14-e1c3-42e7-9e5b-2e5f31fbcade" xlink:to="loc_us-gaap_StatementClassOfStockAxis_7c37e679-73dc-4b40-a2a6-6946c91f0722" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_919fec2c-d2e0-4253-a9b2-42e879a8d96d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_7c37e679-73dc-4b40-a2a6-6946c91f0722" xlink:to="loc_us-gaap_ClassOfStockDomain_919fec2c-d2e0-4253-a9b2-42e879a8d96d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_788230fe-b10d-431d-a353-d876e7850be7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_919fec2c-d2e0-4253-a9b2-42e879a8d96d" xlink:to="loc_us-gaap_CommonClassAMember_788230fe-b10d-431d-a353-d876e7850be7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_b2a91aa2-af22-4857-b42a-8d13aa6b92f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_919fec2c-d2e0-4253-a9b2-42e879a8d96d" xlink:to="loc_us-gaap_CommonClassBMember_b2a91aa2-af22-4857-b42a-8d13aa6b92f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_RedeemableNoncontrollingInterestsMember_b12c409f-d4b8-4b8b-8ac4-83113b1a7d70" xlink:href="vtvt-20220630.xsd#vtvt_RedeemableNoncontrollingInterestsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_919fec2c-d2e0-4253-a9b2-42e879a8d96d" xlink:to="loc_vtvt_RedeemableNoncontrollingInterestsMember_b12c409f-d4b8-4b8b-8ac4-83113b1a7d70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_847b61dc-b272-45b0-9f77-6ca4e6631da2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_bf4f7a14-e1c3-42e7-9e5b-2e5f31fbcade" xlink:to="loc_us-gaap_StatementLineItems_847b61dc-b272-45b0-9f77-6ca4e6631da2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_b4596299-4618-42ef-af83-1b74ad7c528d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInTemporaryEquityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_847b61dc-b272-45b0-9f77-6ca4e6631da2" xlink:to="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_b4596299-4618-42ef-af83-1b74ad7c528d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount_a1148851-f7d4-4850-82e0-025dad4b83cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_b4596299-4618-42ef-af83-1b74ad7c528d" xlink:to="loc_us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount_a1148851-f7d4-4850-82e0-025dad4b83cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossIncludingPortionAttributableToNonredeemableNoncontrollingInterest_8fcbd048-3151-4bc2-8a6b-50ab72036e17" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossIncludingPortionAttributableToNonredeemableNoncontrollingInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_b4596299-4618-42ef-af83-1b74ad7c528d" xlink:to="loc_us-gaap_NetIncomeLossIncludingPortionAttributableToNonredeemableNoncontrollingInterest_8fcbd048-3151-4bc2-8a6b-50ab72036e17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_TemporaryEquityChangeInRedemptionValue_fb7aa68f-20c3-41a0-b66d-f05b83a78e5a" xlink:href="vtvt-20220630.xsd#vtvt_TemporaryEquityChangeInRedemptionValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_b4596299-4618-42ef-af83-1b74ad7c528d" xlink:to="loc_vtvt_TemporaryEquityChangeInRedemptionValue_fb7aa68f-20c3-41a0-b66d-f05b83a78e5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount_90df6ed6-936e-4c47-93cb-bb753eac8fa1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_b4596299-4618-42ef-af83-1b74ad7c528d" xlink:to="loc_us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount_90df6ed6-936e-4c47-93cb-bb753eac8fa1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_847b61dc-b272-45b0-9f77-6ca4e6631da2" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_895e9ea6-0910-4fd2-9ad1-1267dab370c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_895e9ea6-0910-4fd2-9ad1-1267dab370c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_034ffd75-1f47-4739-8bf4-f8264fde9949" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_StockholdersEquity_034ffd75-1f47-4739-8bf4-f8264fde9949" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_08054bfd-a3d9-4119-99b5-325b48040639" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_NetIncomeLoss_08054bfd-a3d9-4119-99b5-325b48040639" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_0f5d9221-cebc-437e-b2d1-77f5de2566f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_0f5d9221-cebc-437e-b2d1-77f5de2566f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_54e12ae4-ff87-4dae-b07d-f18d26a55be3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_54e12ae4-ff87-4dae-b07d-f18d26a55be3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_d22bebf7-10ed-4713-9135-b7de1b6557fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_d22bebf7-10ed-4713-9135-b7de1b6557fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_IssuanceOfClassACommonStockUnderATMOffering_9b0e7335-ede3-493a-9282-bcc9853776d5" xlink:href="vtvt-20220630.xsd#vtvt_IssuanceOfClassACommonStockUnderATMOffering"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_vtvt_IssuanceOfClassACommonStockUnderATMOffering_9b0e7335-ede3-493a-9282-bcc9853776d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_IssuanceOfClassACommonStockUnderATMOfferingValue_356d1e5d-45df-4305-8d7f-526465bc6a12" xlink:href="vtvt-20220630.xsd#vtvt_IssuanceOfClassACommonStockUnderATMOfferingValue"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_vtvt_IssuanceOfClassACommonStockUnderATMOfferingValue_356d1e5d-45df-4305-8d7f-526465bc6a12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_badba30e-eb1b-4319-aba8-005559ffd6a4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_badba30e-eb1b-4319-aba8-005559ffd6a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_771f9341-b3a8-49b7-ba11-1e19c6941ca1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_771f9341-b3a8-49b7-ba11-1e19c6941ca1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_889c6ddb-6157-4d40-8f3e-7cdcf46e0b53" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_889c6ddb-6157-4d40-8f3e-7cdcf46e0b53" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_StockIssuedDuringPeriodSharesPurchaseAgreement_4b78edd6-d2a9-49ca-83be-ec90ef9f55f1" xlink:href="vtvt-20220630.xsd#vtvt_StockIssuedDuringPeriodSharesPurchaseAgreement"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_vtvt_StockIssuedDuringPeriodSharesPurchaseAgreement_4b78edd6-d2a9-49ca-83be-ec90ef9f55f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_StockIssuedDuringPeriodValuePurchaseAgreement_3b6e1d51-9a58-4c7d-b4ed-ebf2ad698fe3" xlink:href="vtvt-20220630.xsd#vtvt_StockIssuedDuringPeriodValuePurchaseAgreement"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_vtvt_StockIssuedDuringPeriodValuePurchaseAgreement_3b6e1d51-9a58-4c7d-b4ed-ebf2ad698fe3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestChangeInRedemptionValue_545c9fa0-04f5-465a-864e-2475de115ae6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestChangeInRedemptionValue"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_MinorityInterestChangeInRedemptionValue_545c9fa0-04f5-465a-864e-2475de115ae6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_7dbe7635-9572-41ea-8ac1-89c4d36cc0ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_7dbe7635-9572-41ea-8ac1-89c4d36cc0ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_7582776b-ba82-47ac-82c8-c7ecace60fbe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4d25a761-1f37-4458-8a92-0abe4abe63dc" xlink:to="loc_us-gaap_StockholdersEquity_7582776b-ba82-47ac-82c8-c7ecace60fbe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CondensedConsolidatedStatementsofCashFlowsUnaudited"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_8908283b-1038-47a6-8002-45cc3a9de2a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_aef5586a-330f-45e9-ad08-311ca83e03e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8908283b-1038-47a6-8002-45cc3a9de2a6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_aef5586a-330f-45e9-ad08-311ca83e03e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_fa01137b-386c-49ae-bd38-f3dd2e6e9f4c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_aef5586a-330f-45e9-ad08-311ca83e03e8" xlink:to="loc_us-gaap_ProfitLoss_fa01137b-386c-49ae-bd38-f3dd2e6e9f4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_b3841cc0-af0f-471a-998c-06cace54985a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_aef5586a-330f-45e9-ad08-311ca83e03e8" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_b3841cc0-af0f-471a-998c-06cace54985a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_de8d6577-b5f8-4c34-956c-446a6b4b2f09" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Depreciation"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_b3841cc0-af0f-471a-998c-06cace54985a" xlink:to="loc_us-gaap_Depreciation_de8d6577-b5f8-4c34-956c-446a6b4b2f09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOperating_5c65083c-61a6-4e26-b3ae-fc51be2ba266" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeOperating"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_b3841cc0-af0f-471a-998c-06cace54985a" xlink:to="loc_us-gaap_InterestIncomeOperating_5c65083c-61a6-4e26-b3ae-fc51be2ba266" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_0f5a4203-0e09-49a9-8441-4f4321e6ec8a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_b3841cc0-af0f-471a-998c-06cace54985a" xlink:to="loc_us-gaap_ShareBasedCompensation_0f5a4203-0e09-49a9-8441-4f4321e6ec8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments_b223595c-474b-4649-b288-a09e9f12ff94" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrealizedGainLossOnInvestments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_b3841cc0-af0f-471a-998c-06cace54985a" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestments_b223595c-474b-4649-b288-a09e9f12ff94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ChangeInFairValueOfWarrantsRelatedParty_930a0268-e750-4cec-8aeb-3b8c5e37625f" xlink:href="vtvt-20220630.xsd#vtvt_ChangeInFairValueOfWarrantsRelatedParty"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_b3841cc0-af0f-471a-998c-06cace54985a" xlink:to="loc_vtvt_ChangeInFairValueOfWarrantsRelatedParty_930a0268-e750-4cec-8aeb-3b8c5e37625f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5f63c9be-366f-4b25-812b-fc6a151e0bfc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_aef5586a-330f-45e9-ad08-311ca83e03e8" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5f63c9be-366f-4b25-812b-fc6a151e0bfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_f3640f28-c8ff-4dbf-b196-b60afb860409" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5f63c9be-366f-4b25-812b-fc6a151e0bfc" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_f3640f28-c8ff-4dbf-b196-b60afb860409" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_c87fc4bb-01de-400f-bce6-6133c44cf2b7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5f63c9be-366f-4b25-812b-fc6a151e0bfc" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_c87fc4bb-01de-400f-bce6-6133c44cf2b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_3d5aeae8-e7fb-4f6d-97cc-90946b89aa62" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5f63c9be-366f-4b25-812b-fc6a151e0bfc" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_3d5aeae8-e7fb-4f6d-97cc-90946b89aa62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_223a979c-cd67-4578-bb90-0bbe0041e2be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5f63c9be-366f-4b25-812b-fc6a151e0bfc" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_223a979c-cd67-4578-bb90-0bbe0041e2be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1bdd5a7d-5f77-4a68-9525-ea1f9897548d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_aef5586a-330f-45e9-ad08-311ca83e03e8" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1bdd5a7d-5f77-4a68-9525-ea1f9897548d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_65b81c1f-4a75-40e0-9060-2699b4b9dbc0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8908283b-1038-47a6-8002-45cc3a9de2a6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_65b81c1f-4a75-40e0-9060-2699b4b9dbc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_3f71d092-391a-4ea5-9d04-5c84ca77448a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_65b81c1f-4a75-40e0-9060-2699b4b9dbc0" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_3f71d092-391a-4ea5-9d04-5c84ca77448a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_40c702ce-6258-470e-b420-4f31fe86d89d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_65b81c1f-4a75-40e0-9060-2699b4b9dbc0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_40c702ce-6258-470e-b420-4f31fe86d89d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0772bb66-8f82-49f3-ba2c-2ee2ff7f0c49" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8908283b-1038-47a6-8002-45cc3a9de2a6" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0772bb66-8f82-49f3-ba2c-2ee2ff7f0c49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ProceedsFromSaleOfCommonStock_98ca6f8b-fcd5-45f1-b784-55d6c98a50bf" xlink:href="vtvt-20220630.xsd#vtvt_ProceedsFromSaleOfCommonStock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0772bb66-8f82-49f3-ba2c-2ee2ff7f0c49" xlink:to="loc_vtvt_ProceedsFromSaleOfCommonStock_98ca6f8b-fcd5-45f1-b784-55d6c98a50bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_14f061c0-2a35-4143-853f-5ddbdec3d330" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0772bb66-8f82-49f3-ba2c-2ee2ff7f0c49" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_14f061c0-2a35-4143-853f-5ddbdec3d330" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_46a02c4f-09b1-4688-b5b1-50660534b45a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0772bb66-8f82-49f3-ba2c-2ee2ff7f0c49" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_46a02c4f-09b1-4688-b5b1-50660534b45a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfNotesPayable_fc807e52-f1b9-4e55-bb13-7e73dda7534d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfNotesPayable"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0772bb66-8f82-49f3-ba2c-2ee2ff7f0c49" xlink:to="loc_us-gaap_RepaymentsOfNotesPayable_fc807e52-f1b9-4e55-bb13-7e73dda7534d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_5f94b42c-24a0-479c-9bf9-46bdf1b7af75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_0772bb66-8f82-49f3-ba2c-2ee2ff7f0c49" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_5f94b42c-24a0-479c-9bf9-46bdf1b7af75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0d22f6eb-f18a-4d51-8af5-1ffc4277e5fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8908283b-1038-47a6-8002-45cc3a9de2a6" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_0d22f6eb-f18a-4d51-8af5-1ffc4277e5fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_1ea7e3c2-260d-4a8b-af5c-98069e2ccc93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8908283b-1038-47a6-8002-45cc3a9de2a6" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_1ea7e3c2-260d-4a8b-af5c-98069e2ccc93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_27e6cb2c-c0a4-465a-81c0-f1335a0a7ad6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8908283b-1038-47a6-8002-45cc3a9de2a6" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_27e6cb2c-c0a4-465a-81c0-f1335a0a7ad6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_fc562a72-d5e6-4f6a-8531-05b3903321c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8908283b-1038-47a6-8002-45cc3a9de2a6" xlink:to="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_fc562a72-d5e6-4f6a-8531-05b3903321c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestChangeInRedemptionValue_2966caf5-0523-44da-8a27-929a62b26cc7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestChangeInRedemptionValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_fc562a72-d5e6-4f6a-8531-05b3903321c4" xlink:to="loc_us-gaap_MinorityInterestChangeInRedemptionValue_2966caf5-0523-44da-8a27-929a62b26cc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesAssumed1_9976ed8a-1711-4c53-af29-b934105d6516" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesAssumed1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_fc562a72-d5e6-4f6a-8531-05b3903321c4" xlink:to="loc_us-gaap_NotesAssumed1_9976ed8a-1711-4c53-af29-b934105d6516" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/DescriptionofBusinessBasisofPresentationandGoingConcern" xlink:type="simple" xlink:href="vtvt-20220630.xsd#DescriptionofBusinessBasisofPresentationandGoingConcern"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/DescriptionofBusinessBasisofPresentationandGoingConcern" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_8c9bcacd-669e-4034-853d-73006c4fbdee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessDescriptionAndBasisOfPresentationTextBlock_f45d1961-2d30-4df8-9879-dbaa7a2077bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessDescriptionAndBasisOfPresentationTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_8c9bcacd-669e-4034-853d-73006c4fbdee" xlink:to="loc_us-gaap_BusinessDescriptionAndBasisOfPresentationTextBlock_f45d1961-2d30-4df8-9879-dbaa7a2077bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/DescriptionofBusinessBasisofPresentationandGoingConcernDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#DescriptionofBusinessBasisofPresentationandGoingConcernDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/DescriptionofBusinessBasisofPresentationandGoingConcernDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_VariableInterestsAndEquityMethodInvestmentsDisclosureAbstract_7e76e62b-8648-4b70-9dc2-8a68f10c50a0" xlink:href="vtvt-20220630.xsd#vtvt_VariableInterestsAndEquityMethodInvestmentsDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsTable_7f8345ac-54b3-4319-994d-eea083c1d2c2" xlink:href="vtvt-20220630.xsd#vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_VariableInterestsAndEquityMethodInvestmentsDisclosureAbstract_7e76e62b-8648-4b70-9dc2-8a68f10c50a0" xlink:to="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsTable_7f8345ac-54b3-4319-994d-eea083c1d2c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_5af79f81-6ccd-4353-989e-f2beaa1c444f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsTable_7f8345ac-54b3-4319-994d-eea083c1d2c2" xlink:to="loc_dei_LegalEntityAxis_5af79f81-6ccd-4353-989e-f2beaa1c444f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_b5b8144c-6a9e-48f3-bc18-4fb401af46b8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_5af79f81-6ccd-4353-989e-f2beaa1c444f" xlink:to="loc_dei_EntityDomain_b5b8144c-6a9e-48f3-bc18-4fb401af46b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_VTvLLCMember_6658fd46-1388-4b8f-a045-e382365bcf18" xlink:href="vtvt-20220630.xsd#vtvt_VTvLLCMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_b5b8144c-6a9e-48f3-bc18-4fb401af46b8" xlink:to="loc_vtvt_VTvLLCMember_6658fd46-1388-4b8f-a045-e382365bcf18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_ce951622-4d8d-4285-bbae-506f2dfc0014" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsTable_7f8345ac-54b3-4319-994d-eea083c1d2c2" xlink:to="loc_us-gaap_StatementClassOfStockAxis_ce951622-4d8d-4285-bbae-506f2dfc0014" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_37403692-2733-4ce8-9256-e729a0470ea5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_ce951622-4d8d-4285-bbae-506f2dfc0014" xlink:to="loc_us-gaap_ClassOfStockDomain_37403692-2733-4ce8-9256-e729a0470ea5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_ddb39c3c-608d-43a4-90af-4d76a8335c02" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_37403692-2733-4ce8-9256-e729a0470ea5" xlink:to="loc_us-gaap_CommonClassAMember_ddb39c3c-608d-43a4-90af-4d76a8335c02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_LicenseAgreementObligationsAxis_1156f624-ded7-4a86-a1ab-4affdfe3a312" xlink:href="vtvt-20220630.xsd#vtvt_LicenseAgreementObligationsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsTable_7f8345ac-54b3-4319-994d-eea083c1d2c2" xlink:to="loc_vtvt_LicenseAgreementObligationsAxis_1156f624-ded7-4a86-a1ab-4affdfe3a312" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_LicenseAgreementObligationsDomain_95dab81a-44f7-4f55-95b4-d8398021ca76" xlink:href="vtvt-20220630.xsd#vtvt_LicenseAgreementObligationsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_LicenseAgreementObligationsAxis_1156f624-ded7-4a86-a1ab-4affdfe3a312" xlink:to="loc_vtvt_LicenseAgreementObligationsDomain_95dab81a-44f7-4f55-95b4-d8398021ca76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_LPCPurchaseAgreementMember_7729a650-efe2-41da-b06f-690630301d74" xlink:href="vtvt-20220630.xsd#vtvt_LPCPurchaseAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_LicenseAgreementObligationsDomain_95dab81a-44f7-4f55-95b4-d8398021ca76" xlink:to="loc_vtvt_LPCPurchaseAgreementMember_7729a650-efe2-41da-b06f-690630301d74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_834fd422-4be9-4e17-a8c2-f22022def4a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsTable_7f8345ac-54b3-4319-994d-eea083c1d2c2" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_834fd422-4be9-4e17-a8c2-f22022def4a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_2e06edba-2fb4-42d0-a1b9-13033006ec20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_834fd422-4be9-4e17-a8c2-f22022def4a8" xlink:to="loc_us-gaap_RelatedPartyDomain_2e06edba-2fb4-42d0-a1b9-13033006ec20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CantorFitzgeraldMember_1667779d-9a44-4e1c-9712-e745e7b892dd" xlink:href="vtvt-20220630.xsd#vtvt_CantorFitzgeraldMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyDomain_2e06edba-2fb4-42d0-a1b9-13033006ec20" xlink:to="loc_vtvt_CantorFitzgeraldMember_1667779d-9a44-4e1c-9712-e745e7b892dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_fc68ec9f-6423-4ff6-91fc-94fd1c5cb80a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsTable_7f8345ac-54b3-4319-994d-eea083c1d2c2" xlink:to="loc_srt_CounterpartyNameAxis_fc68ec9f-6423-4ff6-91fc-94fd1c5cb80a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a364341f-c467-4149-9a83-963812761208" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_fc68ec9f-6423-4ff6-91fc-94fd1c5cb80a" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a364341f-c467-4149-9a83-963812761208" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_G2InvestmentsPurchaseAgreementAndCognaCollaborativeAndLicenseAgreementMember_530d0f4e-b23e-4ac7-92eb-7b59aa3e0360" xlink:href="vtvt-20220630.xsd#vtvt_G2InvestmentsPurchaseAgreementAndCognaCollaborativeAndLicenseAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a364341f-c467-4149-9a83-963812761208" xlink:to="loc_vtvt_G2InvestmentsPurchaseAgreementAndCognaCollaborativeAndLicenseAgreementMember_530d0f4e-b23e-4ac7-92eb-7b59aa3e0360" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_G2InvestmentMember_52df5e31-1cf6-4da7-bcfd-941f51c80288" xlink:href="vtvt-20220630.xsd#vtvt_G2InvestmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a364341f-c467-4149-9a83-963812761208" xlink:to="loc_vtvt_G2InvestmentMember_52df5e31-1cf6-4da7-bcfd-941f51c80288" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_6831a943-bebc-45fe-8d24-cc3847eadf52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsTable_7f8345ac-54b3-4319-994d-eea083c1d2c2" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_6831a943-bebc-45fe-8d24-cc3847eadf52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_dee6bc75-5de3-4aee-b6a8-ecab296929bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_6831a943-bebc-45fe-8d24-cc3847eadf52" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_dee6bc75-5de3-4aee-b6a8-ecab296929bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_dda99b68-ef13-4ea0-9460-3768a0f5e32a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_dee6bc75-5de3-4aee-b6a8-ecab296929bc" xlink:to="loc_us-gaap_SubsequentEventMember_dda99b68-ef13-4ea0-9460-3768a0f5e32a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems_75d43385-266e-474f-9bbf-1425a477f62e" xlink:href="vtvt-20220630.xsd#vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsTable_7f8345ac-54b3-4319-994d-eea083c1d2c2" xlink:to="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems_75d43385-266e-474f-9bbf-1425a477f62e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_PercentageOfNonVotingEconomicInterest_dbe4b11c-7fc2-4029-b28f-e5a5d0da9179" xlink:href="vtvt-20220630.xsd#vtvt_PercentageOfNonVotingEconomicInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems_75d43385-266e-474f-9bbf-1425a477f62e" xlink:to="loc_vtvt_PercentageOfNonVotingEconomicInterest_dbe4b11c-7fc2-4029-b28f-e5a5d0da9179" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_PercentageOfNonVotingEconomicInterestByParent_2f7d7694-1d5e-4970-865b-4f00d8544608" xlink:href="vtvt-20220630.xsd#vtvt_PercentageOfNonVotingEconomicInterestByParent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems_75d43385-266e-474f-9bbf-1425a477f62e" xlink:to="loc_vtvt_PercentageOfNonVotingEconomicInterestByParent_2f7d7694-1d5e-4970-865b-4f00d8544608" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_43a86624-f06e-44bc-ae92-2d8c61bb1f72" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems_75d43385-266e-474f-9bbf-1425a477f62e" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_43a86624-f06e-44bc-ae92-2d8c61bb1f72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_253e1d37-55d2-4ef6-86a8-7214359777db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems_75d43385-266e-474f-9bbf-1425a477f62e" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_253e1d37-55d2-4ef6-86a8-7214359777db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableNetCurrent_0f62e844-eb02-47c6-b20d-5355f0f68a87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableNetCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems_75d43385-266e-474f-9bbf-1425a477f62e" xlink:to="loc_us-gaap_AccountsNotesAndLoansReceivableNetCurrent_0f62e844-eb02-47c6-b20d-5355f0f68a87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_SaleOfStockConsiderationReceivedOnTransactionGross_01e4239d-84f4-43eb-9c6e-5d0097bf1707" xlink:href="vtvt-20220630.xsd#vtvt_SaleOfStockConsiderationReceivedOnTransactionGross"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems_75d43385-266e-474f-9bbf-1425a477f62e" xlink:to="loc_vtvt_SaleOfStockConsiderationReceivedOnTransactionGross_01e4239d-84f4-43eb-9c6e-5d0097bf1707" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_RemainingAvailabilityStockIssuedDuringPeriodValueNewIssues_bb11bb38-51b5-4bff-bf9d-c773b6bb6ee6" xlink:href="vtvt-20220630.xsd#vtvt_RemainingAvailabilityStockIssuedDuringPeriodValueNewIssues"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems_75d43385-266e-474f-9bbf-1425a477f62e" xlink:to="loc_vtvt_RemainingAvailabilityStockIssuedDuringPeriodValueNewIssues_bb11bb38-51b5-4bff-bf9d-c773b6bb6ee6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_18c2a8eb-4df9-4873-a0fb-0f0b471c805a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems_75d43385-266e-474f-9bbf-1425a477f62e" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_18c2a8eb-4df9-4873-a0fb-0f0b471c805a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="vtvt-20220630.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_7a0124ae-fb4a-464d-8b02-3eb25a9fcb15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_e768342d-4ae8-4d19-a293-2d48b6bb80da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_7a0124ae-fb4a-464d-8b02-3eb25a9fcb15" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_e768342d-4ae8-4d19-a293-2d48b6bb80da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="vtvt-20220630.xsd#SummaryofSignificantAccountingPoliciesPolicies"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_b55edcc5-0d2c-4232-b4de-71a07edee6cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_UnauditedInterimFinancialInformationPolicyPolicyTextBlock_93e2f652-dfb7-4933-9fed-6ceafe6fabe2" xlink:href="vtvt-20220630.xsd#vtvt_UnauditedInterimFinancialInformationPolicyPolicyTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_b55edcc5-0d2c-4232-b4de-71a07edee6cc" xlink:to="loc_vtvt_UnauditedInterimFinancialInformationPolicyPolicyTextBlock_93e2f652-dfb7-4933-9fed-6ceafe6fabe2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UseOfEstimates_94c6a855-475b-45e9-99b3-80e5ef88592f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UseOfEstimates"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_b55edcc5-0d2c-4232-b4de-71a07edee6cc" xlink:to="loc_us-gaap_UseOfEstimates_94c6a855-475b-45e9-99b3-80e5ef88592f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskCreditRisk_95f36516-1fd1-4e5f-ba78-340f5ea22fb5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskCreditRisk"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_b55edcc5-0d2c-4232-b4de-71a07edee6cc" xlink:to="loc_us-gaap_ConcentrationRiskCreditRisk_95f36516-1fd1-4e5f-ba78-340f5ea22fb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_df9ef44b-d0da-463f-83ac-e62bb93dc7a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_b55edcc5-0d2c-4232-b4de-71a07edee6cc" xlink:to="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_df9ef44b-d0da-463f-83ac-e62bb93dc7a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_847e9646-cc3a-4c8e-ad02-c506c83b2074" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentPolicyTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_b55edcc5-0d2c-4232-b4de-71a07edee6cc" xlink:to="loc_us-gaap_InvestmentPolicyTextBlock_847e9646-cc3a-4c8e-ad02-c506c83b2074" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock_d17980ef-004d-4334-9add-18110153c61c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerPolicyTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_b55edcc5-0d2c-4232-b4de-71a07edee6cc" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock_d17980ef-004d-4334-9add-18110153c61c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_b217f04b-4ce8-4035-85d2-48f8fa036afc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_b55edcc5-0d2c-4232-b4de-71a07edee6cc" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_b217f04b-4ce8-4035-85d2-48f8fa036afc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_4354ba09-374b-4571-a294-abe66a39d8b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_b55edcc5-0d2c-4232-b4de-71a07edee6cc" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_4354ba09-374b-4571-a294-abe66a39d8b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/SummaryofSignificantAccountingPoliciesAdditionalInformationDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#SummaryofSignificantAccountingPoliciesAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/SummaryofSignificantAccountingPoliciesAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_a12ec63e-7656-4965-b7fe-264d2fddd125" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_SummaryOfSignificantAccountingPoliciesTable_69612490-f469-403d-8ca1-445656dbab1d" xlink:href="vtvt-20220630.xsd#vtvt_SummaryOfSignificantAccountingPoliciesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_a12ec63e-7656-4965-b7fe-264d2fddd125" xlink:to="loc_vtvt_SummaryOfSignificantAccountingPoliciesTable_69612490-f469-403d-8ca1-445656dbab1d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_dfd2eb60-c947-49ac-879d-e75811f4030b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_SummaryOfSignificantAccountingPoliciesTable_69612490-f469-403d-8ca1-445656dbab1d" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_dfd2eb60-c947-49ac-879d-e75811f4030b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_355b526a-abbc-4618-a4f6-dc8b17188aca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_dfd2eb60-c947-49ac-879d-e75811f4030b" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_355b526a-abbc-4618-a4f6-dc8b17188aca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_e79da493-fc73-4a96-a03b-97e1af542ab6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_355b526a-abbc-4618-a4f6-dc8b17188aca" xlink:to="loc_us-gaap_SalesRevenueNetMember_e79da493-fc73-4a96-a03b-97e1af542ab6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_e0c7e342-5359-46c8-9e36-2ffaabd89b06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_SummaryOfSignificantAccountingPoliciesTable_69612490-f469-403d-8ca1-445656dbab1d" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_e0c7e342-5359-46c8-9e36-2ffaabd89b06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_6c79dd5e-ce55-4e7b-bf70-16e38552bf32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_e0c7e342-5359-46c8-9e36-2ffaabd89b06" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_6c79dd5e-ce55-4e7b-bf70-16e38552bf32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_1ea42c02-a899-4d9c-8b34-79a2faa54b2b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_6c79dd5e-ce55-4e7b-bf70-16e38552bf32" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_1ea42c02-a899-4d9c-8b34-79a2faa54b2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_0116080c-f2cf-44c6-977e-83fb8b6a417b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MajorCustomersAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_SummaryOfSignificantAccountingPoliciesTable_69612490-f469-403d-8ca1-445656dbab1d" xlink:to="loc_srt_MajorCustomersAxis_0116080c-f2cf-44c6-977e-83fb8b6a417b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_7fa06729-9b61-44ae-86c4-555df54db409" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_MajorCustomersAxis_0116080c-f2cf-44c6-977e-83fb8b6a417b" xlink:to="loc_srt_NameOfMajorCustomerDomain_7fa06729-9b61-44ae-86c4-555df54db409" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_OneCustomerMember_d098f616-325e-49a4-887a-4d220356b35c" xlink:href="vtvt-20220630.xsd#vtvt_OneCustomerMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_7fa06729-9b61-44ae-86c4-555df54db409" xlink:to="loc_vtvt_OneCustomerMember_d098f616-325e-49a4-887a-4d220356b35c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_SummaryOfSignificantAccountingPoliciesLineItems_9430779d-e2af-4f4c-ad2d-6dfff72025fe" xlink:href="vtvt-20220630.xsd#vtvt_SummaryOfSignificantAccountingPoliciesLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_SummaryOfSignificantAccountingPoliciesTable_69612490-f469-403d-8ca1-445656dbab1d" xlink:to="loc_vtvt_SummaryOfSignificantAccountingPoliciesLineItems_9430779d-e2af-4f4c-ad2d-6dfff72025fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_e3c9c926-26d7-4c88-a62f-3304e2a3cc30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_SummaryOfSignificantAccountingPoliciesLineItems_9430779d-e2af-4f4c-ad2d-6dfff72025fe" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_e3c9c926-26d7-4c88-a62f-3304e2a3cc30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CollaborationAgreements" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CollaborationAgreements"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CollaborationAgreements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_e984557a-e481-4757-8959-9553b554ab31" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_cec36bfd-2023-411d-89fc-80dd29364c53" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_e984557a-e481-4757-8959-9553b554ab31" xlink:to="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_cec36bfd-2023-411d-89fc-80dd29364c53" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CollaborationAgreementsTables" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CollaborationAgreementsTables"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CollaborationAgreementsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_ccadabdf-130a-444f-9890-0a8590c056c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_cdb83893-072d-41f8-84f2-b1afa6fa25d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_ccadabdf-130a-444f-9890-0a8590c056c9" xlink:to="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_cdb83893-072d-41f8-84f2-b1afa6fa25d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ContractWithCustomerContractAssetContractLiabilityAndReceivableChangesTableTextBlock_e6817d27-323f-4f13-b197-88594f6e4306" xlink:href="vtvt-20220630.xsd#vtvt_ContractWithCustomerContractAssetContractLiabilityAndReceivableChangesTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_ccadabdf-130a-444f-9890-0a8590c056c9" xlink:to="loc_vtvt_ContractWithCustomerContractAssetContractLiabilityAndReceivableChangesTableTextBlock_e6817d27-323f-4f13-b197-88594f6e4306" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CollaborationAgreementsAdditionalInformationDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CollaborationAgreementsAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CollaborationAgreementsAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_14340d87-fcb3-4170-9be0-91520ac99e4e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1290fa29-26a0-4816-a55d-4aeb0cbbc45a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_14340d87-fcb3-4170-9be0-91520ac99e4e" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1290fa29-26a0-4816-a55d-4aeb0cbbc45a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_6a23f335-0417-48f8-a65a-67ea2a17d43d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1290fa29-26a0-4816-a55d-4aeb0cbbc45a" xlink:to="loc_us-gaap_TypeOfArrangementAxis_6a23f335-0417-48f8-a65a-67ea2a17d43d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_e95453e4-1e97-444b-a062-5fa55637be81" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_6a23f335-0417-48f8-a65a-67ea2a17d43d" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_e95453e4-1e97-444b-a062-5fa55637be81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_G2InvestmentsPurchaseAgreementAndCognaCollaborativeAndLicenseAgreementMember_dc4fd5cf-e07a-4aea-9ddb-fd681b5334fb" xlink:href="vtvt-20220630.xsd#vtvt_G2InvestmentsPurchaseAgreementAndCognaCollaborativeAndLicenseAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_e95453e4-1e97-444b-a062-5fa55637be81" xlink:to="loc_vtvt_G2InvestmentsPurchaseAgreementAndCognaCollaborativeAndLicenseAgreementMember_dc4fd5cf-e07a-4aea-9ddb-fd681b5334fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_1f3f4e9e-ae02-4bfa-ba8e-6eae3841dd17" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_e95453e4-1e97-444b-a062-5fa55637be81" xlink:to="loc_us-gaap_CollaborativeArrangementMember_1f3f4e9e-ae02-4bfa-ba8e-6eae3841dd17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_f3296dd0-b141-4d31-870e-5703bca59a62" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1290fa29-26a0-4816-a55d-4aeb0cbbc45a" xlink:to="loc_dei_LegalEntityAxis_f3296dd0-b141-4d31-870e-5703bca59a62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_49b3c167-1f27-4508-a588-3dbc93279e38" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_f3296dd0-b141-4d31-870e-5703bca59a62" xlink:to="loc_dei_EntityDomain_49b3c167-1f27-4508-a588-3dbc93279e38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ReneoPharmaceuticalsIncMember_81a729c2-7292-418b-8076-a02a2ce3ff90" xlink:href="vtvt-20220630.xsd#vtvt_ReneoPharmaceuticalsIncMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_49b3c167-1f27-4508-a588-3dbc93279e38" xlink:to="loc_vtvt_ReneoPharmaceuticalsIncMember_81a729c2-7292-418b-8076-a02a2ce3ff90" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_HangzhouZhongmeiHuadongPharmaceuticalCompanyLimitedMember_a57ad88b-6bb8-41a0-b887-c126cae321ff" xlink:href="vtvt-20220630.xsd#vtvt_HangzhouZhongmeiHuadongPharmaceuticalCompanyLimitedMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_49b3c167-1f27-4508-a588-3dbc93279e38" xlink:to="loc_vtvt_HangzhouZhongmeiHuadongPharmaceuticalCompanyLimitedMember_a57ad88b-6bb8-41a0-b887-c126cae321ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_NewsoaraBiopharmaCoLtdMember_0a694ed5-6136-41a0-838a-2a0ccab410bb" xlink:href="vtvt-20220630.xsd#vtvt_NewsoaraBiopharmaCoLtdMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_49b3c167-1f27-4508-a588-3dbc93279e38" xlink:to="loc_vtvt_NewsoaraBiopharmaCoLtdMember_0a694ed5-6136-41a0-838a-2a0ccab410bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_AnterisBioIncMember_0f1ae615-5010-49d9-8d44-23ed87fb9305" xlink:href="vtvt-20220630.xsd#vtvt_AnterisBioIncMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_49b3c167-1f27-4508-a588-3dbc93279e38" xlink:to="loc_vtvt_AnterisBioIncMember_0f1ae615-5010-49d9-8d44-23ed87fb9305" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_JDRFInternationalMember_4e60f45e-cde1-479b-9f8b-8c59727ee2ee" xlink:href="vtvt-20220630.xsd#vtvt_JDRFInternationalMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_49b3c167-1f27-4508-a588-3dbc93279e38" xlink:to="loc_vtvt_JDRFInternationalMember_4e60f45e-cde1-479b-9f8b-8c59727ee2ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsAxis_223c12cc-f9ec-4b83-bc92-0cdafdff6157" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCommitmentsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1290fa29-26a0-4816-a55d-4aeb0cbbc45a" xlink:to="loc_us-gaap_OtherCommitmentsAxis_223c12cc-f9ec-4b83-bc92-0cdafdff6157" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsDomain_13e6677a-4543-4b55-a8df-dfbe1d3e2162" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCommitmentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsAxis_223c12cc-f9ec-4b83-bc92-0cdafdff6157" xlink:to="loc_us-gaap_OtherCommitmentsDomain_13e6677a-4543-4b55-a8df-dfbe1d3e2162" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_PhaseTwoMultiRegionalClinicalTrialMember_7fb3987c-7956-4083-91e6-a9c2dbbe90f7" xlink:href="vtvt-20220630.xsd#vtvt_PhaseTwoMultiRegionalClinicalTrialMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsDomain_13e6677a-4543-4b55-a8df-dfbe1d3e2162" xlink:to="loc_vtvt_PhaseTwoMultiRegionalClinicalTrialMember_7fb3987c-7956-4083-91e6-a9c2dbbe90f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_8c400018-2bcf-4873-ac99-77b5fe47ed68" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1290fa29-26a0-4816-a55d-4aeb0cbbc45a" xlink:to="loc_srt_ProductOrServiceAxis_8c400018-2bcf-4873-ac99-77b5fe47ed68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_16ec02e1-a0b6-43cd-a2c4-0e3d3fc242a6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_8c400018-2bcf-4873-ac99-77b5fe47ed68" xlink:to="loc_srt_ProductsAndServicesDomain_16ec02e1-a0b6-43cd-a2c4-0e3d3fc242a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_LicenseAndTechnologyTransferServicesOfChemistryAndManufacturingKnowHowMember_a671c1d9-5594-41d1-b50a-d9a5cd8cd0a2" xlink:href="vtvt-20220630.xsd#vtvt_LicenseAndTechnologyTransferServicesOfChemistryAndManufacturingKnowHowMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_16ec02e1-a0b6-43cd-a2c4-0e3d3fc242a6" xlink:to="loc_vtvt_LicenseAndTechnologyTransferServicesOfChemistryAndManufacturingKnowHowMember_a671c1d9-5594-41d1-b50a-d9a5cd8cd0a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_LicenseAndTechnologyTransferServicesMember_9a23a8a8-4a8e-4be6-af88-c7a2cf5dd32a" xlink:href="vtvt-20220630.xsd#vtvt_LicenseAndTechnologyTransferServicesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_16ec02e1-a0b6-43cd-a2c4-0e3d3fc242a6" xlink:to="loc_vtvt_LicenseAndTechnologyTransferServicesMember_9a23a8a8-4a8e-4be6-af88-c7a2cf5dd32a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_ccc9bd07-49d5-4738-a661-ad3e6b7ee23a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1290fa29-26a0-4816-a55d-4aeb0cbbc45a" xlink:to="loc_srt_CounterpartyNameAxis_ccc9bd07-49d5-4738-a661-ad3e6b7ee23a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2d85712d-f064-48ea-a814-b80a9a907363" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_ccc9bd07-49d5-4738-a661-ad3e6b7ee23a" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2d85712d-f064-48ea-a814-b80a9a907363" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_G42InvestmentsMember_afc4f23c-829b-48c7-9387-bf5b057d060a" xlink:href="vtvt-20220630.xsd#vtvt_G42InvestmentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2d85712d-f064-48ea-a814-b80a9a907363" xlink:to="loc_vtvt_G42InvestmentsMember_afc4f23c-829b-48c7-9387-bf5b057d060a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CognaMember_3197a510-efce-4790-b6c1-b1568bec28d5" xlink:href="vtvt-20220630.xsd#vtvt_CognaMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_2d85712d-f064-48ea-a814-b80a9a907363" xlink:to="loc_vtvt_CognaMember_3197a510-efce-4790-b6c1-b1568bec28d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_9e902528-2db3-4897-bfa4-03e1339ba8a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1290fa29-26a0-4816-a55d-4aeb0cbbc45a" xlink:to="loc_us-gaap_StatementClassOfStockAxis_9e902528-2db3-4897-bfa4-03e1339ba8a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_efa6f15f-1421-48a6-8fc3-11b601521c48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_9e902528-2db3-4897-bfa4-03e1339ba8a9" xlink:to="loc_us-gaap_ClassOfStockDomain_efa6f15f-1421-48a6-8fc3-11b601521c48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_630019ba-ae60-44e9-9775-8be6cc4b572d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_efa6f15f-1421-48a6-8fc3-11b601521c48" xlink:to="loc_us-gaap_CommonClassAMember_630019ba-ae60-44e9-9775-8be6cc4b572d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_1290fa29-26a0-4816-a55d-4aeb0cbbc45a" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_ba98982f-6577-4d47-8123-a2f6e296396f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_ba98982f-6577-4d47-8123-a2f6e296396f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_f3bb8287-ad14-471d-b8fd-01fd064e12c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_f3bb8287-ad14-471d-b8fd-01fd064e12c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_29d44b60-2214-494e-864a-cbff0072caac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_29d44b60-2214-494e-864a-cbff0072caac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_SaleOfStockConsiderationReceivedOnTransactionGross_b4751b8c-5fcf-4f50-94c7-ce4e9a601001" xlink:href="vtvt-20220630.xsd#vtvt_SaleOfStockConsiderationReceivedOnTransactionGross"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_SaleOfStockConsiderationReceivedOnTransactionGross_b4751b8c-5fcf-4f50-94c7-ce4e9a601001" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_f5348fa6-3841-47af-9445-2ffe041c92be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_f5348fa6-3841-47af-9445-2ffe041c92be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableNetCurrent_55498078-e190-4463-a873-cb6ed9c103ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableNetCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_AccountsNotesAndLoansReceivableNetCurrent_55498078-e190-4463-a873-cb6ed9c103ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_SaleOfStockConsiderationReceivablePaymentPeriod_04a86795-d185-43b2-99b9-89abbcb7dd55" xlink:href="vtvt-20220630.xsd#vtvt_SaleOfStockConsiderationReceivablePaymentPeriod"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_SaleOfStockConsiderationReceivablePaymentPeriod_04a86795-d185-43b2-99b9-89abbcb7dd55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CollaborativeArrangementContingentConsiderationTransferredAggregateShareValue_6c477d56-dda4-4f4b-ab80-2e283f549ae4" xlink:href="vtvt-20220630.xsd#vtvt_CollaborativeArrangementContingentConsiderationTransferredAggregateShareValue"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_CollaborativeArrangementContingentConsiderationTransferredAggregateShareValue_6c477d56-dda4-4f4b-ab80-2e283f549ae4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CollaborateArrangementContingentConsiderationTransferredCash_954e867e-ca26-44fe-8341-497745509730" xlink:href="vtvt-20220630.xsd#vtvt_CollaborateArrangementContingentConsiderationTransferredCash"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_CollaborateArrangementContingentConsiderationTransferredCash_954e867e-ca26-44fe-8341-497745509730" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CollaborativeArrangementRoyaltiesReceivablePercentage_724f748e-9dba-4bc5-89a4-926574aaa83b" xlink:href="vtvt-20220630.xsd#vtvt_CollaborativeArrangementRoyaltiesReceivablePercentage"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_CollaborativeArrangementRoyaltiesReceivablePercentage_724f748e-9dba-4bc5-89a4-926574aaa83b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CollaborativeArrangementRoyaltiesReceivablePeriod_80898bc8-0697-48d9-874e-c10a14422894" xlink:href="vtvt-20220630.xsd#vtvt_CollaborativeArrangementRoyaltiesReceivablePeriod"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_CollaborativeArrangementRoyaltiesReceivablePeriod_80898bc8-0697-48d9-874e-c10a14422894" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_7fb6aebc-25fb-461c-a6b7-6d141ca27176" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharePrice"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_SharePrice_7fb6aebc-25fb-461c-a6b7-6d141ca27176" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValueOutstanding_6ead0813-6e39-40ad-92fe-db09acb68eb1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValueOutstanding"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_CommonStockValueOutstanding_6ead0813-6e39-40ad-92fe-db09acb68eb1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_5fa81c25-1ccf-4f73-890d-6306da327314" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_5fa81c25-1ccf-4f73-890d-6306da327314" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CollaborativeArrangementNoteReceivableDiscountPaid_d2baae0e-d9ed-453f-a0ef-b2f4f4b16adc" xlink:href="vtvt-20220630.xsd#vtvt_CollaborativeArrangementNoteReceivableDiscountPaid"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_CollaborativeArrangementNoteReceivableDiscountPaid_d2baae0e-d9ed-453f-a0ef-b2f4f4b16adc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_9f38ead6-5634-4e19-af7a-0656e64dfe4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_9f38ead6-5634-4e19-af7a-0656e64dfe4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_AdjustmentsToTransactionPriceForPerformanceObligations_89992f3f-b59d-4d63-a5b6-c599fa93c5a0" xlink:href="vtvt-20220630.xsd#vtvt_AdjustmentsToTransactionPriceForPerformanceObligations"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_AdjustmentsToTransactionPriceForPerformanceObligations_89992f3f-b59d-4d63-a5b6-c599fa93c5a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_MaximumSponsoringContributionAmount_1a0a5c95-4d24-475e-928f-95a8f7a6de98" xlink:href="vtvt-20220630.xsd#vtvt_MaximumSponsoringContributionAmount"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_MaximumSponsoringContributionAmount_1a0a5c95-4d24-475e-928f-95a8f7a6de98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_PotentialDevelopmentAndRegulatoryMilestonePaymentsReceivable_65b29af0-b73f-4ac9-9745-d3518db01ab9" xlink:href="vtvt-20220630.xsd#vtvt_PotentialDevelopmentAndRegulatoryMilestonePaymentsReceivable"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_PotentialDevelopmentAndRegulatoryMilestonePaymentsReceivable_65b29af0-b73f-4ac9-9745-d3518db01ab9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CollaborativeArrangementTechnologyTransferServicesPeriod_d8d943b2-6383-4c63-baa6-44f98a0599e1" xlink:href="vtvt-20220630.xsd#vtvt_CollaborativeArrangementTechnologyTransferServicesPeriod"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_CollaborativeArrangementTechnologyTransferServicesPeriod_d8d943b2-6383-4c63-baa6-44f98a0599e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_94bac0e7-308c-4cc8-912b-f62c0677ed84" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligation"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_94bac0e7-308c-4cc8-912b-f62c0677ed84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCumulativeCatchUpAdjustmentToRevenueChangeInEstimateOfTransactionPrice_4da5e39e-03f7-4442-a191-9c6d2318125d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCumulativeCatchUpAdjustmentToRevenueChangeInEstimateOfTransactionPrice"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCumulativeCatchUpAdjustmentToRevenueChangeInEstimateOfTransactionPrice_4da5e39e-03f7-4442-a191-9c6d2318125d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_LicenseFeeReceived_60c61974-f387-4902-ad01-b635b69fb3a6" xlink:href="vtvt-20220630.xsd#vtvt_LicenseFeeReceived"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_LicenseFeeReceived_60c61974-f387-4902-ad01-b635b69fb3a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromInterestAndDividendsReceived_5b41fb57-cea3-4a05-9333-fc36bc66af58" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromInterestAndDividendsReceived"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_ProceedsFromInterestAndDividendsReceived_5b41fb57-cea3-4a05-9333-fc36bc66af58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_MaximumResearchFundingReceivableBasedOnAchievementOfResearchAndDevelopmentMilestones_a865dde3-8e6e-460b-8023-d2207ede9f5e" xlink:href="vtvt-20220630.xsd#vtvt_MaximumResearchFundingReceivableBasedOnAchievementOfResearchAndDevelopmentMilestones"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_MaximumResearchFundingReceivableBasedOnAchievementOfResearchAndDevelopmentMilestones_a865dde3-8e6e-460b-8023-d2207ede9f5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_MaximumFundingPercentageOfResearchAndDevelopmentMilestones_6eb0c2ac-e229-4e59-bdf2-8cc28327c1d5" xlink:href="vtvt-20220630.xsd#vtvt_MaximumFundingPercentageOfResearchAndDevelopmentMilestones"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_MaximumFundingPercentageOfResearchAndDevelopmentMilestones_6eb0c2ac-e229-4e59-bdf2-8cc28327c1d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_FundingReceived_ac18369f-791e-476f-a6c4-89ebf2a6dbcd" xlink:href="vtvt-20220630.xsd#vtvt_FundingReceived"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_vtvt_FundingReceived_ac18369f-791e-476f-a6c4-89ebf2a6dbcd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_25aa4013-878f-4256-8647-64b284a82677" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2baafd68-524a-470b-b6b5-1f1aa74cbe7c" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_25aa4013-878f-4256-8647-64b284a82677" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CollaborationAgreementsSummaryofContractLiabilitiesRelatedtoCompanysCollaborationAgreementsDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CollaborationAgreementsSummaryofContractLiabilitiesRelatedtoCompanysCollaborationAgreementsDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CollaborationAgreementsSummaryofContractLiabilitiesRelatedtoCompanysCollaborationAgreementsDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueDisclosureAbstract_08b79775-04aa-4985-975a-a664ee69ca52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredRevenueDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e91ca986-1320-460e-8447-971ef8b3adc5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueDisclosureAbstract_08b79775-04aa-4985-975a-a664ee69ca52" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e91ca986-1320-460e-8447-971ef8b3adc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_68adeef0-18f8-4251-b461-97dbf2365fc7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueDisclosureAbstract_08b79775-04aa-4985-975a-a664ee69ca52" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_68adeef0-18f8-4251-b461-97dbf2365fc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_4dfb6752-c100-4dfa-a3b3-52f6c9b52f90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueDisclosureAbstract_08b79775-04aa-4985-975a-a664ee69ca52" xlink:to="loc_us-gaap_ContractWithCustomerLiability_4dfb6752-c100-4dfa-a3b3-52f6c9b52f90" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CollaborationAgreementsContractwithCustomerContractAssetContractLiabilityandReceivableChangesDetails" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CollaborationAgreementsContractwithCustomerContractAssetContractLiabilityandReceivableChangesDetails"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CollaborationAgreementsContractwithCustomerContractAssetContractLiabilityandReceivableChangesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_a6329cf1-a9b8-4bdd-b9f3-72962eaf27fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ChangeInContractWithCustomerLiabilityRollForward_805174bd-1bf8-407e-b8f8-51d3b738226d" xlink:href="vtvt-20220630.xsd#vtvt_ChangeInContractWithCustomerLiabilityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_a6329cf1-a9b8-4bdd-b9f3-72962eaf27fd" xlink:to="loc_vtvt_ChangeInContractWithCustomerLiabilityRollForward_805174bd-1bf8-407e-b8f8-51d3b738226d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_063dd3dd-b6dd-42cd-bb5d-8c78a94ed236" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ChangeInContractWithCustomerLiabilityRollForward_805174bd-1bf8-407e-b8f8-51d3b738226d" xlink:to="loc_us-gaap_ContractWithCustomerLiability_063dd3dd-b6dd-42cd-bb5d-8c78a94ed236" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_b634b198-a649-4b5e-93e0-dfe99f7a17f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ChangeInContractWithCustomerLiabilityRollForward_805174bd-1bf8-407e-b8f8-51d3b738226d" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_b634b198-a649-4b5e-93e0-dfe99f7a17f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityIncreaseDecreaseForContractAcquiredInBusinessCombination_bd789566-f64d-45cd-94e6-15a4707bc305" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityIncreaseDecreaseForContractAcquiredInBusinessCombination"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ChangeInContractWithCustomerLiabilityRollForward_805174bd-1bf8-407e-b8f8-51d3b738226d" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityIncreaseDecreaseForContractAcquiredInBusinessCombination_bd789566-f64d-45cd-94e6-15a4707bc305" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_9413b9fc-d5c3-4616-a8a0-94786cc26978" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ChangeInContractWithCustomerLiabilityRollForward_805174bd-1bf8-407e-b8f8-51d3b738226d" xlink:to="loc_us-gaap_ContractWithCustomerLiability_9413b9fc-d5c3-4616-a8a0-94786cc26978" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/ShareBasedCompensation" xlink:type="simple" xlink:href="vtvt-20220630.xsd#ShareBasedCompensation"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/ShareBasedCompensation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_1380a963-1086-4ddb-b433-fcf245ca337c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_b087ca10-2096-42d6-ae42-43f4ed41e4fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_1380a963-1086-4ddb-b433-fcf245ca337c" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_b087ca10-2096-42d6-ae42-43f4ed41e4fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/ShareBasedCompensationTables" xlink:type="simple" xlink:href="vtvt-20220630.xsd#ShareBasedCompensationTables"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/ShareBasedCompensationTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_d8c4bfd6-81a3-4820-a265-cd5bbda9f1d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_8dd8074a-f2dd-41cd-921e-0f46a03437d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_d8c4bfd6-81a3-4820-a265-cd5bbda9f1d0" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_8dd8074a-f2dd-41cd-921e-0f46a03437d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_5969ce09-d6f3-41b3-8faf-767801c78f6c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_d8c4bfd6-81a3-4820-a265-cd5bbda9f1d0" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_5969ce09-d6f3-41b3-8faf-767801c78f6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/ShareBasedCompensationAdditionalInformationDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#ShareBasedCompensationAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/ShareBasedCompensationAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAbstract_7779c215-296b-45b7-a756-606cc090db9b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5aff849f-7016-444f-bed5-2799cfe111f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_7779c215-296b-45b7-a756-606cc090db9b" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5aff849f-7016-444f-bed5-2799cfe111f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_c279fb15-553e-442f-8ac0-b5583dbbece9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5aff849f-7016-444f-bed5-2799cfe111f2" xlink:to="loc_us-gaap_AwardTypeAxis_c279fb15-553e-442f-8ac0-b5583dbbece9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_29637e9d-4ae3-43df-a6ce-b7bb5e901b89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_c279fb15-553e-442f-8ac0-b5583dbbece9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_29637e9d-4ae3-43df-a6ce-b7bb5e901b89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_3d9e9332-74d0-4a92-9294-7b4706e95cbf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_29637e9d-4ae3-43df-a6ce-b7bb5e901b89" xlink:to="loc_us-gaap_EmployeeStockOptionMember_3d9e9332-74d0-4a92-9294-7b4706e95cbf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_542a85d0-2d5b-4092-82a5-0301b1299848" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5aff849f-7016-444f-bed5-2799cfe111f2" xlink:to="loc_srt_TitleOfIndividualAxis_542a85d0-2d5b-4092-82a5-0301b1299848" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_81d21a89-6ff2-4dd9-95f3-90a9c311b8bf" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_TitleOfIndividualAxis_542a85d0-2d5b-4092-82a5-0301b1299848" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_81d21a89-6ff2-4dd9-95f3-90a9c311b8bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_StrategicAdvisorMember_09a4877c-1e0e-4d2a-9ea0-ae5bf1a045cf" xlink:href="vtvt-20220630.xsd#vtvt_StrategicAdvisorMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_81d21a89-6ff2-4dd9-95f3-90a9c311b8bf" xlink:to="loc_vtvt_StrategicAdvisorMember_09a4877c-1e0e-4d2a-9ea0-ae5bf1a045cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b9bae2e8-7f83-473f-a7c8-8f5839bcfd2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5aff849f-7016-444f-bed5-2799cfe111f2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b9bae2e8-7f83-473f-a7c8-8f5839bcfd2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_912137aa-ef00-4d97-b16c-e4f97234c3f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b9bae2e8-7f83-473f-a7c8-8f5839bcfd2d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_912137aa-ef00-4d97-b16c-e4f97234c3f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_3789d115-6552-4339-94c9-93e766f44ec4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b9bae2e8-7f83-473f-a7c8-8f5839bcfd2d" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_3789d115-6552-4339-94c9-93e766f44ec4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_bf82a6bd-11e1-473f-a887-28f278f75b6d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b9bae2e8-7f83-473f-a7c8-8f5839bcfd2d" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_bf82a6bd-11e1-473f-a887-28f278f75b6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_f1b05015-acf6-46ba-b04a-ea0525f87172" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b9bae2e8-7f83-473f-a7c8-8f5839bcfd2d" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_f1b05015-acf6-46ba-b04a-ea0525f87172" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_e5b7d040-2c3f-40bd-b62d-370ac2ccaa16" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b9bae2e8-7f83-473f-a7c8-8f5839bcfd2d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_e5b7d040-2c3f-40bd-b62d-370ac2ccaa16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_5366fbc9-26e2-4a6b-8f1a-26b9488c6a44" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b9bae2e8-7f83-473f-a7c8-8f5839bcfd2d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_5366fbc9-26e2-4a6b-8f1a-26b9488c6a44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_d93a7f63-c405-400a-b6a7-9338ba231fed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b9bae2e8-7f83-473f-a7c8-8f5839bcfd2d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_d93a7f63-c405-400a-b6a7-9338ba231fed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelled_3a717fe0-e706-40d4-b52c-2cf81093c7fb" xlink:href="vtvt-20220630.xsd#vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelled"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b9bae2e8-7f83-473f-a7c8-8f5839bcfd2d" xlink:to="loc_vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelled_3a717fe0-e706-40d4-b52c-2cf81093c7fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/ShareBasedCompensationSummaryofStockAwardActivityforthePeriodDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#ShareBasedCompensationSummaryofStockAwardActivityforthePeriodDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/ShareBasedCompensationSummaryofStockAwardActivityforthePeriodDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedArrangementsToObtainGoodsAndServicesAbstract_f59cd1c5-75f0-4cae-a709-0483c4e307a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedArrangementsToObtainGoodsAndServicesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_e889b617-34c0-47ee-8376-503955b05ee3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedArrangementsToObtainGoodsAndServicesAbstract_f59cd1c5-75f0-4cae-a709-0483c4e307a7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_e889b617-34c0-47ee-8376-503955b05ee3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_3af68f46-05a8-468e-94e5-3bdaefa2f4a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_e889b617-34c0-47ee-8376-503955b05ee3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_3af68f46-05a8-468e-94e5-3bdaefa2f4a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_143cd13e-f909-41a8-a7bd-79059255be5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_e889b617-34c0-47ee-8376-503955b05ee3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_143cd13e-f909-41a8-a7bd-79059255be5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_4bd93668-fb0c-4761-8adc-a0056ca0a5e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_e889b617-34c0-47ee-8376-503955b05ee3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_4bd93668-fb0c-4761-8adc-a0056ca0a5e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_9dd502c7-52cd-4ca7-9107-a1e27f9bb69a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_e889b617-34c0-47ee-8376-503955b05ee3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_9dd502c7-52cd-4ca7-9107-a1e27f9bb69a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_e0d20f64-c8ca-4ba8-8071-c1fbdd1c28a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedArrangementsToObtainGoodsAndServicesAbstract_f59cd1c5-75f0-4cae-a709-0483c4e307a7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_e0d20f64-c8ca-4ba8-8071-c1fbdd1c28a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_b12ff744-02b2-4b1b-931c-f35444b08f15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedArrangementsToObtainGoodsAndServicesAbstract_f59cd1c5-75f0-4cae-a709-0483c4e307a7" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_b12ff744-02b2-4b1b-931c-f35444b08f15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableNumber_3666e819-9d64-4dc2-9687-3ef2f792b43f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableNumber"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedArrangementsToObtainGoodsAndServicesAbstract_f59cd1c5-75f0-4cae-a709-0483c4e307a7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableNumber_3666e819-9d64-4dc2-9687-3ef2f792b43f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageRemainingContractualTerm1_dca35bb8-05e8-41f7-a11f-34ff4fe9a05f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageRemainingContractualTerm1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedArrangementsToObtainGoodsAndServicesAbstract_f59cd1c5-75f0-4cae-a709-0483c4e307a7" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageRemainingContractualTerm1_dca35bb8-05e8-41f7-a11f-34ff4fe9a05f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollForward_de454769-3302-491e-93a4-0f7289b50693" xlink:href="vtvt-20220630.xsd#vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollForward"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedArrangementsToObtainGoodsAndServicesAbstract_f59cd1c5-75f0-4cae-a709-0483c4e307a7" xlink:to="loc_vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollForward_de454769-3302-491e-93a4-0f7289b50693" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_ec33269e-5787-49af-b1a1-aec22594f31a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollForward_de454769-3302-491e-93a4-0f7289b50693" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_ec33269e-5787-49af-b1a1-aec22594f31a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_dd6ab60d-fad1-4b33-8956-bae3d21c43b6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollForward_de454769-3302-491e-93a4-0f7289b50693" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_dd6ab60d-fad1-4b33-8956-bae3d21c43b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_4ad2ef27-1767-4225-833f-80983f6472d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollForward_de454769-3302-491e-93a4-0f7289b50693" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_4ad2ef27-1767-4225-833f-80983f6472d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_ec5c8bdc-727f-4f1e-bb92-679e5a191783" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollForward_de454769-3302-491e-93a4-0f7289b50693" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_ec5c8bdc-727f-4f1e-bb92-679e5a191783" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_a242dfe4-5cea-454d-aa3e-07956df72d6c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedArrangementsToObtainGoodsAndServicesAbstract_f59cd1c5-75f0-4cae-a709-0483c4e307a7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_a242dfe4-5cea-454d-aa3e-07956df72d6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageExercisePrice_f5069d1f-6241-4f58-9a63-ded31735aee6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageExercisePrice"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedArrangementsToObtainGoodsAndServicesAbstract_f59cd1c5-75f0-4cae-a709-0483c4e307a7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageExercisePrice_f5069d1f-6241-4f58-9a63-ded31735aee6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/ShareBasedCompensationSummaryofCompensationExpenseRelatedtoGrantsofStockOptionsDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#ShareBasedCompensationSummaryofCompensationExpenseRelatedtoGrantsofStockOptionsDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/ShareBasedCompensationSummaryofCompensationExpenseRelatedtoGrantsofStockOptionsDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_9f80aa2a-7857-473b-a8a7-735cd3fe804a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_6a7316af-61d6-4214-a7d1-c1f3e321ddce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_9f80aa2a-7857-473b-a8a7-735cd3fe804a" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_6a7316af-61d6-4214-a7d1-c1f3e321ddce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_185df70f-adb0-437c-9115-5003c682dd60" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_6a7316af-61d6-4214-a7d1-c1f3e321ddce" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_185df70f-adb0-437c-9115-5003c682dd60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_51eecb77-d7ef-4735-9114-6c59a42de5b3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_185df70f-adb0-437c-9115-5003c682dd60" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_51eecb77-d7ef-4735-9114-6c59a42de5b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_3390695e-9912-4809-ad8c-4315efa02d4e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_51eecb77-d7ef-4735-9114-6c59a42de5b3" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_3390695e-9912-4809-ad8c-4315efa02d4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_ea7fbd11-defe-404f-885b-bc1bcb7aca30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_51eecb77-d7ef-4735-9114-6c59a42de5b3" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_ea7fbd11-defe-404f-885b-bc1bcb7aca30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_b6707a24-5d4e-4001-bdf7-140184dbcb95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_6a7316af-61d6-4214-a7d1-c1f3e321ddce" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_b6707a24-5d4e-4001-bdf7-140184dbcb95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_721f798d-e3a6-4f19-a274-3e81dc66f892" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_b6707a24-5d4e-4001-bdf7-140184dbcb95" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_721f798d-e3a6-4f19-a274-3e81dc66f892" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/Investments" xlink:type="simple" xlink:href="vtvt-20220630.xsd#Investments"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/Investments" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_fc487c11-bef4-4ff8-8deb-368105ea371a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_4f7e42e7-ab64-42cb-a421-9886e088bf45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_fc487c11-bef4-4ff8-8deb-368105ea371a" xlink:to="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_4f7e42e7-ab64-42cb-a421-9886e088bf45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/InvestmentsTables" xlink:type="simple" xlink:href="vtvt-20220630.xsd#InvestmentsTables"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/InvestmentsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_56fc4f2c-a997-4db4-8197-0da50df45d60" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_EquitySecuritiesWithAndWithoutReadilyDeterminableFairValueTableTableTextBlock_24a0012c-ed21-4cda-964e-f2b38f32d476" xlink:href="vtvt-20220630.xsd#vtvt_EquitySecuritiesWithAndWithoutReadilyDeterminableFairValueTableTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_56fc4f2c-a997-4db4-8197-0da50df45d60" xlink:to="loc_vtvt_EquitySecuritiesWithAndWithoutReadilyDeterminableFairValueTableTableTextBlock_24a0012c-ed21-4cda-964e-f2b38f32d476" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/InvestmentsAdditionalInformationDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#InvestmentsAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/InvestmentsAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0c9e8276-2f4a-4799-82b2-b3905c5532fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_1a46f7a9-8bbb-4be0-88c9-4db5673bc013" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_0c9e8276-2f4a-4799-82b2-b3905c5532fb" xlink:to="loc_us-gaap_StatementTable_1a46f7a9-8bbb-4be0-88c9-4db5673bc013" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_96e6d301-f932-49af-9ae2-9db7a8dce20e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_1a46f7a9-8bbb-4be0-88c9-4db5673bc013" xlink:to="loc_dei_LegalEntityAxis_96e6d301-f932-49af-9ae2-9db7a8dce20e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_c6124c20-a5e7-49a8-861b-73acb32f969c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_96e6d301-f932-49af-9ae2-9db7a8dce20e" xlink:to="loc_dei_EntityDomain_c6124c20-a5e7-49a8-861b-73acb32f969c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ReneoPharmaceuticalsIncMember_c6875180-ac37-4770-b361-33c5ad16e25a" xlink:href="vtvt-20220630.xsd#vtvt_ReneoPharmaceuticalsIncMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_c6124c20-a5e7-49a8-861b-73acb32f969c" xlink:to="loc_vtvt_ReneoPharmaceuticalsIncMember_c6875180-ac37-4770-b361-33c5ad16e25a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_246597e0-6cc7-41a5-b93f-a60a563d9efe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_1a46f7a9-8bbb-4be0-88c9-4db5673bc013" xlink:to="loc_us-gaap_StatementLineItems_246597e0-6cc7-41a5-b93f-a60a563d9efe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_InvestmentOwnershipPercentage_16eb14fc-6198-426c-b178-0947de4b1463" xlink:href="vtvt-20220630.xsd#vtvt_InvestmentOwnershipPercentage"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_246597e0-6cc7-41a5-b93f-a60a563d9efe" xlink:to="loc_vtvt_InvestmentOwnershipPercentage_16eb14fc-6198-426c-b178-0947de4b1463" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments_c58af4eb-3da2-439a-818a-9cfc05aed6b6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrealizedGainLossOnInvestments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_246597e0-6cc7-41a5-b93f-a60a563d9efe" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestments_c58af4eb-3da2-439a-818a-9cfc05aed6b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/InvestmentsScheduleofEquityInvestmentswithandwithoutReadilyDeterminableFairValuesAssessedDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#InvestmentsScheduleofEquityInvestmentswithandwithoutReadilyDeterminableFairValuesAssessedDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/InvestmentsScheduleofEquityInvestmentswithandwithoutReadilyDeterminableFairValuesAssessedDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_04776d40-4a91-4ea0-af08-1a0804434586" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueTable_abd240de-acbc-404f-8a39-7aff41133f5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_04776d40-4a91-4ea0-af08-1a0804434586" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueTable_abd240de-acbc-404f-8a39-7aff41133f5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_81bfeeef-bd28-4c7f-874a-e9f0ae156b98" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueTable_abd240de-acbc-404f-8a39-7aff41133f5c" xlink:to="loc_dei_LegalEntityAxis_81bfeeef-bd28-4c7f-874a-e9f0ae156b98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_10be41a5-d483-4a65-a633-a8908bc5ec95" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_81bfeeef-bd28-4c7f-874a-e9f0ae156b98" xlink:to="loc_dei_EntityDomain_10be41a5-d483-4a65-a633-a8908bc5ec95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ReneoPharmaceuticalsIncMember_3cffadcc-a46f-48f6-9bdd-42d341066f5a" xlink:href="vtvt-20220630.xsd#vtvt_ReneoPharmaceuticalsIncMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_10be41a5-d483-4a65-a633-a8908bc5ec95" xlink:to="loc_vtvt_ReneoPharmaceuticalsIncMember_3cffadcc-a46f-48f6-9bdd-42d341066f5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_AnterisBioIncMember_179e9f9f-4f70-4dd6-83bf-d3b6a20c68ad" xlink:href="vtvt-20220630.xsd#vtvt_AnterisBioIncMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_10be41a5-d483-4a65-a633-a8908bc5ec95" xlink:to="loc_vtvt_AnterisBioIncMember_179e9f9f-4f70-4dd6-83bf-d3b6a20c68ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_087b56d9-c0bb-4860-8936-0afa6aa5484c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueTable_abd240de-acbc-404f-8a39-7aff41133f5c" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_087b56d9-c0bb-4860-8936-0afa6aa5484c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_2ba3b49f-07f3-41e8-bbe3-e74d2aaef162" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_087b56d9-c0bb-4860-8936-0afa6aa5484c" xlink:to="loc_us-gaap_EquityComponentDomain_2ba3b49f-07f3-41e8-bbe3-e74d2aaef162" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_6cabb31e-c6c9-483f-8896-ea82f81508cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_2ba3b49f-07f3-41e8-bbe3-e74d2aaef162" xlink:to="loc_us-gaap_CommonStockMember_6cabb31e-c6c9-483f-8896-ea82f81508cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockMember_81949502-92ff-46d0-9d57-936053270b1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_2ba3b49f-07f3-41e8-bbe3-e74d2aaef162" xlink:to="loc_us-gaap_PreferredStockMember_81949502-92ff-46d0-9d57-936053270b1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueLineItems_2b15c7e8-f02b-483f-95ed-2fdc0b115495" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueTable_abd240de-acbc-404f-8a39-7aff41133f5c" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueLineItems_2b15c7e8-f02b-483f-95ed-2fdc0b115495" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_EquityInvestmentsWithReadilyDeterminableFairValue_3b6655ca-e3a9-410c-ad5d-a3fc0efe4130" xlink:href="vtvt-20220630.xsd#vtvt_EquityInvestmentsWithReadilyDeterminableFairValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueLineItems_2b15c7e8-f02b-483f-95ed-2fdc0b115495" xlink:to="loc_vtvt_EquityInvestmentsWithReadilyDeterminableFairValue_3b6655ca-e3a9-410c-ad5d-a3fc0efe4130" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_05a8923b-b7f8-457c-b6e9-8d7614be8a97" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueLineItems_2b15c7e8-f02b-483f-95ed-2fdc0b115495" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_05a8923b-b7f8-457c-b6e9-8d7614be8a97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CommitmentsandContingencies"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CommitmentsandContingencies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_32337004-9391-4533-87cc-ae39ed780ba9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_2ab7dc69-2926-42de-bcc8-21efa2044ef0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_32337004-9391-4533-87cc-ae39ed780ba9" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_2ab7dc69-2926-42de-bcc8-21efa2044ef0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CommitmentsandContingenciesAdditionalInformationDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#CommitmentsandContingenciesAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/CommitmentsandContingenciesAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_8f71a745-b730-46cf-9f3c-1eeb7f162d56" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CommitmentsAndContingenciesTable_cc7750da-e494-4694-a60f-5e310a7b4e91" xlink:href="vtvt-20220630.xsd#vtvt_CommitmentsAndContingenciesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_8f71a745-b730-46cf-9f3c-1eeb7f162d56" xlink:to="loc_vtvt_CommitmentsAndContingenciesTable_cc7750da-e494-4694-a60f-5e310a7b4e91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsAxis_9a31026f-f1a0-4e7f-ab39-1b53f66a7b28" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCommitmentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_CommitmentsAndContingenciesTable_cc7750da-e494-4694-a60f-5e310a7b4e91" xlink:to="loc_us-gaap_OtherCommitmentsAxis_9a31026f-f1a0-4e7f-ab39-1b53f66a7b28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsDomain_0f298387-1472-4f55-ae57-62f0ee890bad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCommitmentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsAxis_9a31026f-f1a0-4e7f-ab39-1b53f66a7b28" xlink:to="loc_us-gaap_OtherCommitmentsDomain_0f298387-1472-4f55-ae57-62f0ee890bad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_DevelopmentalAndRegulatoryMilestonePaymentMember_fc536038-f7c6-4aa1-a340-a58dbea939ea" xlink:href="vtvt-20220630.xsd#vtvt_DevelopmentalAndRegulatoryMilestonePaymentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsDomain_0f298387-1472-4f55-ae57-62f0ee890bad" xlink:to="loc_vtvt_DevelopmentalAndRegulatoryMilestonePaymentMember_fc536038-f7c6-4aa1-a340-a58dbea939ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_SalesBasedMilestonesPaymentMember_f6e70150-4adc-4ed8-9944-52c93edf6bc3" xlink:href="vtvt-20220630.xsd#vtvt_SalesBasedMilestonesPaymentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsDomain_0f298387-1472-4f55-ae57-62f0ee890bad" xlink:to="loc_vtvt_SalesBasedMilestonesPaymentMember_f6e70150-4adc-4ed8-9944-52c93edf6bc3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_SatisfactionOfMilestonePaymentMember_3e0243bc-3029-4701-9f75-090951fca716" xlink:href="vtvt-20220630.xsd#vtvt_SatisfactionOfMilestonePaymentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsDomain_0f298387-1472-4f55-ae57-62f0ee890bad" xlink:to="loc_vtvt_SatisfactionOfMilestonePaymentMember_3e0243bc-3029-4701-9f75-090951fca716" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_4decbe50-e335-46af-8251-a8720e4cdaea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_CommitmentsAndContingenciesTable_cc7750da-e494-4694-a60f-5e310a7b4e91" xlink:to="loc_us-gaap_TypeOfArrangementAxis_4decbe50-e335-46af-8251-a8720e4cdaea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8183bebf-bb3a-441a-9cc3-5b4de5b456fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_4decbe50-e335-46af-8251-a8720e4cdaea" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8183bebf-bb3a-441a-9cc3-5b4de5b456fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_NovoLicenseAgreementMember_df2a426c-c476-435e-970f-ffc44ab2188c" xlink:href="vtvt-20220630.xsd#vtvt_NovoLicenseAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_8183bebf-bb3a-441a-9cc3-5b4de5b456fb" xlink:to="loc_vtvt_NovoLicenseAgreementMember_df2a426c-c476-435e-970f-ffc44ab2188c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_20727495-222c-464c-90ee-09a144c01412" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_CommitmentsAndContingenciesTable_cc7750da-e494-4694-a60f-5e310a7b4e91" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_20727495-222c-464c-90ee-09a144c01412" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1162c02d-145a-4cde-a571-e2db9bab0889" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_20727495-222c-464c-90ee-09a144c01412" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1162c02d-145a-4cde-a571-e2db9bab0889" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_OtherIndicationMember_f5644d33-5c6d-4ceb-92da-12b5f16d19d4" xlink:href="vtvt-20220630.xsd#vtvt_OtherIndicationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1162c02d-145a-4cde-a571-e2db9bab0889" xlink:to="loc_vtvt_OtherIndicationMember_f5644d33-5c6d-4ceb-92da-12b5f16d19d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_TypeOneDiabetesMember_f9157c6d-92f3-41e1-8a96-0dd8b4db2588" xlink:href="vtvt-20220630.xsd#vtvt_TypeOneDiabetesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1162c02d-145a-4cde-a571-e2db9bab0889" xlink:to="loc_vtvt_TypeOneDiabetesMember_f9157c6d-92f3-41e1-8a96-0dd8b4db2588" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_TypeTwoDiabetesMember_7fc0240f-b0c4-45b3-97b6-9e884c77a9c2" xlink:href="vtvt-20220630.xsd#vtvt_TypeTwoDiabetesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1162c02d-145a-4cde-a571-e2db9bab0889" xlink:to="loc_vtvt_TypeTwoDiabetesMember_7fc0240f-b0c4-45b3-97b6-9e884c77a9c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_307a99ce-06d9-49ab-a2eb-2d8d5016c11e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_CommitmentsAndContingenciesTable_cc7750da-e494-4694-a60f-5e310a7b4e91" xlink:to="loc_srt_RangeAxis_307a99ce-06d9-49ab-a2eb-2d8d5016c11e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_b74f0ab1-63e0-4408-bf21-12f2794e1b6c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_307a99ce-06d9-49ab-a2eb-2d8d5016c11e" xlink:to="loc_srt_RangeMember_b74f0ab1-63e0-4408-bf21-12f2794e1b6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_3ee08e29-fe4c-4f1b-beb5-b9eee952b5e6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_b74f0ab1-63e0-4408-bf21-12f2794e1b6c" xlink:to="loc_srt_MaximumMember_3ee08e29-fe4c-4f1b-beb5-b9eee952b5e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CommitmentsAndContingenciesLineItems_3004dc03-5619-427a-876a-dd3586055cf8" xlink:href="vtvt-20220630.xsd#vtvt_CommitmentsAndContingenciesLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_CommitmentsAndContingenciesTable_cc7750da-e494-4694-a60f-5e310a7b4e91" xlink:to="loc_vtvt_CommitmentsAndContingenciesLineItems_3004dc03-5619-427a-876a-dd3586055cf8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_PotentialMilestonePayment_ea0d9763-6c27-486d-b7dd-f4a563b2741c" xlink:href="vtvt-20220630.xsd#vtvt_PotentialMilestonePayment"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_CommitmentsAndContingenciesLineItems_3004dc03-5619-427a-876a-dd3586055cf8" xlink:to="loc_vtvt_PotentialMilestonePayment_ea0d9763-6c27-486d-b7dd-f4a563b2741c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/Leases" xlink:type="simple" xlink:href="vtvt-20220630.xsd#Leases"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/Leases" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_0258d415-db5c-4d5f-9465-e159a0b2123f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeasesTextBlock_0a952764-1e8c-4661-a115-e5a4d22bdf84" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeasesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_0258d415-db5c-4d5f-9465-e159a0b2123f" xlink:to="loc_us-gaap_LesseeOperatingLeasesTextBlock_0a952764-1e8c-4661-a115-e5a4d22bdf84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/LeasesTables" xlink:type="simple" xlink:href="vtvt-20220630.xsd#LeasesTables"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/LeasesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_ea810116-38ea-477f-9eef-8ae6f4695f37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock_ebb5137b-dd4e-473a-a80c-9cdcea6d8afa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_ea810116-38ea-477f-9eef-8ae6f4695f37" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock_ebb5137b-dd4e-473a-a80c-9cdcea6d8afa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/LeasesDetails" xlink:type="simple" xlink:href="vtvt-20220630.xsd#LeasesDetails"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/LeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_16e68ed9-87c2-47d2-b9ca-258ed97f71fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_LesseeOperatingLeaseTerminationPeriod_a6989e45-5b72-4ce0-acba-68c6b0ec7947" xlink:href="vtvt-20220630.xsd#vtvt_LesseeOperatingLeaseTerminationPeriod"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_16e68ed9-87c2-47d2-b9ca-258ed97f71fb" xlink:to="loc_vtvt_LesseeOperatingLeaseTerminationPeriod_a6989e45-5b72-4ce0-acba-68c6b0ec7947" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_beafa5f9-a9bf-431b-9a14-f46023068b8f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseRenewalTerm"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_16e68ed9-87c2-47d2-b9ca-258ed97f71fb" xlink:to="loc_us-gaap_LesseeOperatingLeaseRenewalTerm_beafa5f9-a9bf-431b-9a14-f46023068b8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_487b3e85-8d8a-4e1f-849f-598b88844ed2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_16e68ed9-87c2-47d2-b9ca-258ed97f71fb" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_487b3e85-8d8a-4e1f-849f-598b88844ed2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_0ac87264-53c2-4d67-bf5a-ba6d0d6395df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_16e68ed9-87c2-47d2-b9ca-258ed97f71fb" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_0ac87264-53c2-4d67-bf5a-ba6d0d6395df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_e34ed037-5d6b-46f8-a0b3-87d8da649b81" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_846e9237-1743-45b6-b60b-2bb383f50739" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_e34ed037-5d6b-46f8-a0b3-87d8da649b81" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_846e9237-1743-45b6-b60b-2bb383f50739" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_a9fd20f7-35dc-409c-b646-7af4428fa4ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_e34ed037-5d6b-46f8-a0b3-87d8da649b81" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_a9fd20f7-35dc-409c-b646-7af4428fa4ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_c7377e7b-1fe5-43f0-a8c6-6c96acf2fc0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_e34ed037-5d6b-46f8-a0b3-87d8da649b81" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_c7377e7b-1fe5-43f0-a8c6-6c96acf2fc0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_7cd066d3-78d7-46f8-823b-57d2fe691086" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_e34ed037-5d6b-46f8-a0b3-87d8da649b81" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_7cd066d3-78d7-46f8-823b-57d2fe691086" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_0c3f67a4-de5d-4263-a5a6-17e075a5fb86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_e34ed037-5d6b-46f8-a0b3-87d8da649b81" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_0c3f67a4-de5d-4263-a5a6-17e075a5fb86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_3809941e-47dd-4cff-8585-c23ca5da03ba" xlink:href="vtvt-20220630.xsd#vtvt_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_e34ed037-5d6b-46f8-a0b3-87d8da649b81" xlink:to="loc_vtvt_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_3809941e-47dd-4cff-8585-c23ca5da03ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_a37d202b-2492-4b53-89ec-1d0c44f3ebf4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_e34ed037-5d6b-46f8-a0b3-87d8da649b81" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_a37d202b-2492-4b53-89ec-1d0c44f3ebf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_OperatingLeasesImputedInterest_780d81a7-d187-4187-8383-23735bb63a29" xlink:href="vtvt-20220630.xsd#vtvt_OperatingLeasesImputedInterest"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_e34ed037-5d6b-46f8-a0b3-87d8da649b81" xlink:to="loc_vtvt_OperatingLeasesImputedInterest_780d81a7-d187-4187-8383-23735bb63a29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_fd33de84-92fd-4e8e-b1ca-5c0c45ab2808" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilitiesPaymentsDueAbstract_e34ed037-5d6b-46f8-a0b3-87d8da649b81" xlink:to="loc_us-gaap_OperatingLeaseLiability_fd33de84-92fd-4e8e-b1ca-5c0c45ab2808" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail_1" xlink:type="simple" xlink:href="vtvt-20220630.xsd#LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail_1"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail_1" xlink:type="extended"/>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/RedeemableNoncontrollingInterest" xlink:type="simple" xlink:href="vtvt-20220630.xsd#RedeemableNoncontrollingInterest"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/RedeemableNoncontrollingInterest" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestAbstract_82e3be9c-440c-4a41-a238-4b15b99dfb96" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncontrollingInterestAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestDisclosureTextBlock_4081a2c7-2be0-497a-9fcc-3f92eeb8e807" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_82e3be9c-440c-4a41-a238-4b15b99dfb96" xlink:to="loc_us-gaap_MinorityInterestDisclosureTextBlock_4081a2c7-2be0-497a-9fcc-3f92eeb8e807" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/RedeemableNoncontrollingInterestTables" xlink:type="simple" xlink:href="vtvt-20220630.xsd#RedeemableNoncontrollingInterestTables"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/RedeemableNoncontrollingInterestTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestAbstract_742ca109-a5d7-4d6e-9a2f-2cb7ccdbc1c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncontrollingInterestAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestEffectsOfChangesNetTextBlock_e7a6fff4-48e8-4929-9161-3b238e73d4ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestEffectsOfChangesNetTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_742ca109-a5d7-4d6e-9a2f-2cb7ccdbc1c6" xlink:to="loc_us-gaap_ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestEffectsOfChangesNetTextBlock_e7a6fff4-48e8-4929-9161-3b238e73d4ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/RedeemableNoncontrollingInterestAdditionalInformationDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#RedeemableNoncontrollingInterestAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/RedeemableNoncontrollingInterestAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestAbstract_e888e504-d43c-4695-bfab-ff3708fad95c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncontrollingInterestAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestTable_215a4af3-e4a0-41a7-858d-59b9a96c8385" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_e888e504-d43c-4695-bfab-ff3708fad95c" xlink:to="loc_us-gaap_MinorityInterestTable_215a4af3-e4a0-41a7-858d-59b9a96c8385" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_f60568f5-98ea-4ad6-9f7f-6ee88ba147e0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MinorityInterestTable_215a4af3-e4a0-41a7-858d-59b9a96c8385" xlink:to="loc_dei_LegalEntityAxis_f60568f5-98ea-4ad6-9f7f-6ee88ba147e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_69502b4c-6d40-4319-95f1-0fef9a6bf865" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_f60568f5-98ea-4ad6-9f7f-6ee88ba147e0" xlink:to="loc_dei_EntityDomain_69502b4c-6d40-4319-95f1-0fef9a6bf865" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_VTvLLCMember_274d696c-9dfc-40de-93d9-84018260a7b2" xlink:href="vtvt-20220630.xsd#vtvt_VTvLLCMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_69502b4c-6d40-4319-95f1-0fef9a6bf865" xlink:to="loc_vtvt_VTvLLCMember_274d696c-9dfc-40de-93d9-84018260a7b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_72dc97bf-c78b-439d-a482-92a3ebf15f11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MinorityInterestTable_215a4af3-e4a0-41a7-858d-59b9a96c8385" xlink:to="loc_us-gaap_StatementClassOfStockAxis_72dc97bf-c78b-439d-a482-92a3ebf15f11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_fc74c26d-39d0-48c9-9abb-1c9076ae2427" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_72dc97bf-c78b-439d-a482-92a3ebf15f11" xlink:to="loc_us-gaap_ClassOfStockDomain_fc74c26d-39d0-48c9-9abb-1c9076ae2427" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_c1ba015f-638e-429f-919e-c7306626b3a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_fc74c26d-39d0-48c9-9abb-1c9076ae2427" xlink:to="loc_us-gaap_CommonClassAMember_c1ba015f-638e-429f-919e-c7306626b3a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_fc5f2033-393a-41e1-9962-35bbb1f5a45b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConversionOfStockByUniqueDescriptionAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MinorityInterestTable_215a4af3-e4a0-41a7-858d-59b9a96c8385" xlink:to="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_fc5f2033-393a-41e1-9962-35bbb1f5a45b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockNameDomain_234edac1-081b-4b32-a405-e379e169741e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConversionOfStockNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_fc5f2033-393a-41e1-9962-35bbb1f5a45b" xlink:to="loc_us-gaap_ConversionOfStockNameDomain_234edac1-081b-4b32-a405-e379e169741e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ExchangeOfRedeemableNonControllingInterestToClassACommonStockMember_69377408-ce3b-4a92-aaa5-5eb4122efc81" xlink:href="vtvt-20220630.xsd#vtvt_ExchangeOfRedeemableNonControllingInterestToClassACommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConversionOfStockNameDomain_234edac1-081b-4b32-a405-e379e169741e" xlink:to="loc_vtvt_ExchangeOfRedeemableNonControllingInterestToClassACommonStockMember_69377408-ce3b-4a92-aaa5-5eb4122efc81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestLineItems_01d7b1db-f663-42d1-8c85-f04a6b4395c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MinorityInterestTable_215a4af3-e4a0-41a7-858d-59b9a96c8385" xlink:to="loc_us-gaap_MinorityInterestLineItems_01d7b1db-f663-42d1-8c85-f04a6b4395c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_PercentageOfNonVotingEconomicInterest_d51a28a2-1272-420a-a38f-3c14f0ae2348" xlink:href="vtvt-20220630.xsd#vtvt_PercentageOfNonVotingEconomicInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MinorityInterestLineItems_01d7b1db-f663-42d1-8c85-f04a6b4395c5" xlink:to="loc_vtvt_PercentageOfNonVotingEconomicInterest_d51a28a2-1272-420a-a38f-3c14f0ae2348" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_RedeemableNonControllingInterestExchangeAgreementStockConversionRatio_9b75cd76-c011-424c-8b24-948f73d42692" xlink:href="vtvt-20220630.xsd#vtvt_RedeemableNonControllingInterestExchangeAgreementStockConversionRatio"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MinorityInterestLineItems_01d7b1db-f663-42d1-8c85-f04a6b4395c5" xlink:to="loc_vtvt_RedeemableNonControllingInterestExchangeAgreementStockConversionRatio_9b75cd76-c011-424c-8b24-948f73d42692" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_PeriodUsedToDetermineExchangeValueBasedOnWeightedAveragePriceOfClassCommonStock_26cd9d52-ca82-4379-a673-daa13bf3b2e0" xlink:href="vtvt-20220630.xsd#vtvt_PeriodUsedToDetermineExchangeValueBasedOnWeightedAveragePriceOfClassCommonStock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MinorityInterestLineItems_01d7b1db-f663-42d1-8c85-f04a6b4395c5" xlink:to="loc_vtvt_PeriodUsedToDetermineExchangeValueBasedOnWeightedAveragePriceOfClassCommonStock_26cd9d52-ca82-4379-a673-daa13bf3b2e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_RedeemableNoncontrollingInterestTemporaryEquityRedemptionValue_01197fb2-bbbe-4257-a706-2b49f8a2c71d" xlink:href="vtvt-20220630.xsd#vtvt_RedeemableNoncontrollingInterestTemporaryEquityRedemptionValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MinorityInterestLineItems_01d7b1db-f663-42d1-8c85-f04a6b4395c5" xlink:to="loc_vtvt_RedeemableNoncontrollingInterestTemporaryEquityRedemptionValue_01197fb2-bbbe-4257-a706-2b49f8a2c71d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/RedeemableNoncontrollingInterestSummaryofNetIncomeAttributabletoVtvTherapeuticsIncDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#RedeemableNoncontrollingInterestSummaryofNetIncomeAttributabletoVtvTherapeuticsIncDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/RedeemableNoncontrollingInterestSummaryofNetIncomeAttributabletoVtvTherapeuticsIncDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncontrollingInterestAbstract_36f64a6e-397e-408a-9773-2bb97f8f8a9e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncontrollingInterestAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_19b8594d-4c75-4b69-a076-7fa19a8cb7a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_36f64a6e-397e-408a-9773-2bb97f8f8a9e" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_19b8594d-4c75-4b69-a076-7fa19a8cb7a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ConsolidationChangesWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParent_b6e115a4-6f3e-4c27-a458-28d34666d1db" xlink:href="vtvt-20220630.xsd#vtvt_ConsolidationChangesWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_36f64a6e-397e-408a-9773-2bb97f8f8a9e" xlink:to="loc_vtvt_ConsolidationChangesWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParent_b6e115a4-6f3e-4c27-a458-28d34666d1db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangeDueToNetIncomeAttributableToParentAndEffectsOfChangesNet_1c536494-38df-4bd0-a1ca-28b2dddc1a6d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangeDueToNetIncomeAttributableToParentAndEffectsOfChangesNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncontrollingInterestAbstract_36f64a6e-397e-408a-9773-2bb97f8f8a9e" xlink:to="loc_us-gaap_ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangeDueToNetIncomeAttributableToParentAndEffectsOfChangesNet_1c536494-38df-4bd0-a1ca-28b2dddc1a6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/StockholdersDeficit" xlink:type="simple" xlink:href="vtvt-20220630.xsd#StockholdersDeficit"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/StockholdersDeficit" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_b9069e55-1fe6-46de-af1b-c74290172c79" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_74ab2ff4-2136-4647-a27f-bcb077bea9cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_b9069e55-1fe6-46de-af1b-c74290172c79" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_74ab2ff4-2136-4647-a27f-bcb077bea9cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/StockholdersDeficitAdditionalInformationDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#StockholdersDeficitAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/StockholdersDeficitAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_8dada229-767c-41e9-97f6-2dc06c31c2a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_02aa81c7-b751-4a1d-b3e1-5f6d94c01018" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_8dada229-767c-41e9-97f6-2dc06c31c2a0" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_02aa81c7-b751-4a1d-b3e1-5f6d94c01018" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_9d811c23-4f1f-461d-be2a-b49a1097446f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_02aa81c7-b751-4a1d-b3e1-5f6d94c01018" xlink:to="loc_us-gaap_StatementClassOfStockAxis_9d811c23-4f1f-461d-be2a-b49a1097446f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_b07d6ff4-9d26-41a7-ae97-475f5e101a68" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_9d811c23-4f1f-461d-be2a-b49a1097446f" xlink:to="loc_us-gaap_ClassOfStockDomain_b07d6ff4-9d26-41a7-ae97-475f5e101a68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_9257189f-c506-454e-82f4-cfe95903697c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_b07d6ff4-9d26-41a7-ae97-475f5e101a68" xlink:to="loc_us-gaap_CommonClassAMember_9257189f-c506-454e-82f4-cfe95903697c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_4795ba80-6584-4538-9123-8578af8cbad7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_b07d6ff4-9d26-41a7-ae97-475f5e101a68" xlink:to="loc_us-gaap_CommonStockMember_4795ba80-6584-4538-9123-8578af8cbad7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_ef489cf6-4cbc-444b-86fd-b9e9b028ab58" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_02aa81c7-b751-4a1d-b3e1-5f6d94c01018" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_ef489cf6-4cbc-444b-86fd-b9e9b028ab58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_5b2dd163-c922-4d47-94d5-5b7c53af0338" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_ef489cf6-4cbc-444b-86fd-b9e9b028ab58" xlink:to="loc_us-gaap_RelatedPartyDomain_5b2dd163-c922-4d47-94d5-5b7c53af0338" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CantorFitzgeraldMember_b808636e-3367-4177-99fa-d77ac360830e" xlink:href="vtvt-20220630.xsd#vtvt_CantorFitzgeraldMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyDomain_5b2dd163-c922-4d47-94d5-5b7c53af0338" xlink:to="loc_vtvt_CantorFitzgeraldMember_b808636e-3367-4177-99fa-d77ac360830e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_LPCPurchaseAgreementMember_cbb12eaf-7ba4-40a8-8f52-adc7131ed3fd" xlink:href="vtvt-20220630.xsd#vtvt_LPCPurchaseAgreementMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyDomain_5b2dd163-c922-4d47-94d5-5b7c53af0338" xlink:to="loc_vtvt_LPCPurchaseAgreementMember_cbb12eaf-7ba4-40a8-8f52-adc7131ed3fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransactionTypeAxis_15704c40-4502-4a8e-940e-674d592ee532" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransactionTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_02aa81c7-b751-4a1d-b3e1-5f6d94c01018" xlink:to="loc_us-gaap_TransactionTypeAxis_15704c40-4502-4a8e-940e-674d592ee532" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransactionDomain_2e370fdc-98b9-4893-8259-90301f209932" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransactionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransactionTypeAxis_15704c40-4502-4a8e-940e-674d592ee532" xlink:to="loc_us-gaap_TransactionDomain_2e370fdc-98b9-4893-8259-90301f209932" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_AtTheMarketOfferingMember_407f7276-a584-4cb1-bc45-709051fae255" xlink:href="vtvt-20220630.xsd#vtvt_AtTheMarketOfferingMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransactionDomain_2e370fdc-98b9-4893-8259-90301f209932" xlink:to="loc_vtvt_AtTheMarketOfferingMember_407f7276-a584-4cb1-bc45-709051fae255" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_203b86ed-fd0e-4c54-ab4e-0f664d10e776" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_02aa81c7-b751-4a1d-b3e1-5f6d94c01018" xlink:to="loc_srt_RangeAxis_203b86ed-fd0e-4c54-ab4e-0f664d10e776" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e34b559d-9f06-4db0-8df4-a8ea74d84b0a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_203b86ed-fd0e-4c54-ab4e-0f664d10e776" xlink:to="loc_srt_RangeMember_e34b559d-9f06-4db0-8df4-a8ea74d84b0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_f68263fa-65da-405c-a731-a7e9e7e65f8d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_e34b559d-9f06-4db0-8df4-a8ea74d84b0a" xlink:to="loc_srt_MaximumMember_f68263fa-65da-405c-a731-a7e9e7e65f8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_f28ba33c-3901-4afb-9a9d-e29ef1249865" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_02aa81c7-b751-4a1d-b3e1-5f6d94c01018" xlink:to="loc_srt_CounterpartyNameAxis_f28ba33c-3901-4afb-9a9d-e29ef1249865" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_8be12187-413b-4316-b6c0-8b24956e85a8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_f28ba33c-3901-4afb-9a9d-e29ef1249865" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_8be12187-413b-4316-b6c0-8b24956e85a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_G42InvestmentsMember_d7b96804-cd99-47c4-b7b3-f5f063e421ec" xlink:href="vtvt-20220630.xsd#vtvt_G42InvestmentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_8be12187-413b-4316-b6c0-8b24956e85a8" xlink:to="loc_vtvt_G42InvestmentsMember_d7b96804-cd99-47c4-b7b3-f5f063e421ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_02aa81c7-b751-4a1d-b3e1-5f6d94c01018" xlink:to="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_f8453c33-fba8-4bbc-bcab-661674bf564e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_f8453c33-fba8-4bbc-bcab-661674bf564e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_IncreaseInCommonStockSharesAuthorized_49a00240-b6a8-48cc-bee4-d93b17ad778d" xlink:href="vtvt-20220630.xsd#vtvt_IncreaseInCommonStockSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_vtvt_IncreaseInCommonStockSharesAuthorized_49a00240-b6a8-48cc-bee4-d93b17ad778d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CommonStockAndPreferredStockSharesAuthorized_0d21c326-48f6-4c9b-9afd-1fe58bd13629" xlink:href="vtvt-20220630.xsd#vtvt_CommonStockAndPreferredStockSharesAuthorized"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_vtvt_CommonStockAndPreferredStockSharesAuthorized_0d21c326-48f6-4c9b-9afd-1fe58bd13629" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_a5a489d7-e942-4e21-932d-03ed612cf324" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_a5a489d7-e942-4e21-932d-03ed612cf324" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_45846185-d1a8-4e52-8282-bb87d929f7ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_45846185-d1a8-4e52-8282-bb87d929f7ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_e4a3b6e2-99c0-44ac-9d1a-026840a3299a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_e4a3b6e2-99c0-44ac-9d1a-026840a3299a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_SaleOfStockConsiderationReceivedOnTransactionGross_11a77e66-0b42-460a-a495-48d029369617" xlink:href="vtvt-20220630.xsd#vtvt_SaleOfStockConsiderationReceivedOnTransactionGross"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_vtvt_SaleOfStockConsiderationReceivedOnTransactionGross_11a77e66-0b42-460a-a495-48d029369617" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_dbde5245-061e-4552-a88c-43435d67e572" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_dbde5245-061e-4552-a88c-43435d67e572" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableNetCurrent_420333f7-05ee-400a-82c0-7f839af47576" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableNetCurrent"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_us-gaap_AccountsNotesAndLoansReceivableNetCurrent_420333f7-05ee-400a-82c0-7f839af47576" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_SaleOfStockConsiderationReceivablesPaymentTerm_4ae6b9fd-8053-42aa-b454-48559b266150" xlink:href="vtvt-20220630.xsd#vtvt_SaleOfStockConsiderationReceivablesPaymentTerm"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_vtvt_SaleOfStockConsiderationReceivablesPaymentTerm_4ae6b9fd-8053-42aa-b454-48559b266150" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_27f832c6-bbd1-4565-a1bb-79742372eb38" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_27f832c6-bbd1-4565-a1bb-79742372eb38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_PublicFloat_8e9af72b-673b-4c47-bc1c-158eafde6b75" xlink:href="vtvt-20220630.xsd#vtvt_PublicFloat"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_vtvt_PublicFloat_8e9af72b-673b-4c47-bc1c-158eafde6b75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_AggregateOfferingPriceOfShares_78f2fe3f-88ac-48e1-8469-55943fc8c380" xlink:href="vtvt-20220630.xsd#vtvt_AggregateOfferingPriceOfShares"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_vtvt_AggregateOfferingPriceOfShares_78f2fe3f-88ac-48e1-8469-55943fc8c380" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_9eef0de4-d859-4021-8694-214515b748ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_e391ad05-d931-4931-b76f-83726d7599f8" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_9eef0de4-d859-4021-8694-214515b748ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/RelatedPartyTransactions" xlink:type="simple" xlink:href="vtvt-20220630.xsd#RelatedPartyTransactions"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/RelatedPartyTransactions" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_1663be85-2fc3-47cf-b864-f4588046bcab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_e443d22b-9d25-4eab-ba72-83983bf4b1b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_1663be85-2fc3-47cf-b864-f4588046bcab" xlink:to="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_e443d22b-9d25-4eab-ba72-83983bf4b1b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/RelatedPartyTransactionsAdditionalInformationDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#RelatedPartyTransactionsAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/RelatedPartyTransactionsAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_CommitmentContingencyAndRelatedPartyTransactionsAbstract_e3238ffc-640f-454e-861a-0bf988fbbddf" xlink:href="vtvt-20220630.xsd#vtvt_CommitmentContingencyAndRelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_a62a9538-c341-4048-a507-22b98209f010" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_CommitmentContingencyAndRelatedPartyTransactionsAbstract_e3238ffc-640f-454e-861a-0bf988fbbddf" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_a62a9538-c341-4048-a507-22b98209f010" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_ef37792b-8578-46a7-a5c7-7284566d3e0b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_a62a9538-c341-4048-a507-22b98209f010" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_ef37792b-8578-46a7-a5c7-7284566d3e0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_071d69fe-9cde-4f4e-b39f-d79a58a9bc24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_ef37792b-8578-46a7-a5c7-7284566d3e0b" xlink:to="loc_us-gaap_RelatedPartyDomain_071d69fe-9cde-4f4e-b39f-d79a58a9bc24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_MacAndrewsAndForbesIncorporatedMember_f79d6191-095a-4312-b7d8-20215671ef0f" xlink:href="vtvt-20220630.xsd#vtvt_MacAndrewsAndForbesIncorporatedMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyDomain_071d69fe-9cde-4f4e-b39f-d79a58a9bc24" xlink:to="loc_vtvt_MacAndrewsAndForbesIncorporatedMember_f79d6191-095a-4312-b7d8-20215671ef0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_f4646042-ccf9-46ad-bd08-6e4a841b4df4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_a62a9538-c341-4048-a507-22b98209f010" xlink:to="loc_us-gaap_StatementClassOfStockAxis_f4646042-ccf9-46ad-bd08-6e4a841b4df4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_3ae130f6-af32-4c37-8ce0-56543901e34b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_f4646042-ccf9-46ad-bd08-6e4a841b4df4" xlink:to="loc_us-gaap_ClassOfStockDomain_3ae130f6-af32-4c37-8ce0-56543901e34b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_f83c2065-694f-4fcd-9974-dc66c1b38418" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_3ae130f6-af32-4c37-8ce0-56543901e34b" xlink:to="loc_us-gaap_CommonClassBMember_f83c2065-694f-4fcd-9974-dc66c1b38418" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_3e945f50-c1e6-4de4-b0f2-2e8e6ff699b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_3ae130f6-af32-4c37-8ce0-56543901e34b" xlink:to="loc_us-gaap_CommonClassAMember_3e945f50-c1e6-4de4-b0f2-2e8e6ff699b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_b1965859-ace8-4342-80b4-6f265355e61c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConversionOfStockByUniqueDescriptionAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_a62a9538-c341-4048-a507-22b98209f010" xlink:to="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_b1965859-ace8-4342-80b4-6f265355e61c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockNameDomain_48ffe8a3-3b45-4c4b-9e4b-2f6e3183cdde" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConversionOfStockNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConversionOfStockByUniqueDescriptionAxis_b1965859-ace8-4342-80b4-6f265355e61c" xlink:to="loc_us-gaap_ConversionOfStockNameDomain_48ffe8a3-3b45-4c4b-9e4b-2f6e3183cdde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ExchangeOfRedeemableNonControllingInterestToClassACommonStockMember_c16cbe27-7eed-4ff1-9022-d28d16f5422a" xlink:href="vtvt-20220630.xsd#vtvt_ExchangeOfRedeemableNonControllingInterestToClassACommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConversionOfStockNameDomain_48ffe8a3-3b45-4c4b-9e4b-2f6e3183cdde" xlink:to="loc_vtvt_ExchangeOfRedeemableNonControllingInterestToClassACommonStockMember_c16cbe27-7eed-4ff1-9022-d28d16f5422a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_c1ac0824-6490-44e8-91be-ca28ad9813a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_a62a9538-c341-4048-a507-22b98209f010" xlink:to="loc_us-gaap_RelatedPartyTransactionLineItems_c1ac0824-6490-44e8-91be-ca28ad9813a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsInAndAdvancesToAffiliatesBalanceShares_9154172c-abc4-4737-a5ff-266b5fae4686" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsInAndAdvancesToAffiliatesBalanceShares"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_c1ac0824-6490-44e8-91be-ca28ad9813a7" xlink:to="loc_us-gaap_InvestmentsInAndAdvancesToAffiliatesBalanceShares_9154172c-abc4-4737-a5ff-266b5fae4686" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_OwnershipPercentageOfMajorityOwner_cc9a049a-dcf5-46f9-9300-af6d12c390f6" xlink:href="vtvt-20220630.xsd#vtvt_OwnershipPercentageOfMajorityOwner"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_c1ac0824-6490-44e8-91be-ca28ad9813a7" xlink:to="loc_vtvt_OwnershipPercentageOfMajorityOwner_cc9a049a-dcf5-46f9-9300-af6d12c390f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_RedeemableNonControllingInterestExchangeAgreementStockConversionRatio_a6d5bd65-3cff-417f-abc1-a0af594ea2d8" xlink:href="vtvt-20220630.xsd#vtvt_RedeemableNonControllingInterestExchangeAgreementStockConversionRatio"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_c1ac0824-6490-44e8-91be-ca28ad9813a7" xlink:to="loc_vtvt_RedeemableNonControllingInterestExchangeAgreementStockConversionRatio_a6d5bd65-3cff-417f-abc1-a0af594ea2d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_PercentageOfAmountOfCashSavings_dd1f537e-513a-4364-be2e-37efd891ba8f" xlink:href="vtvt-20220630.xsd#vtvt_PercentageOfAmountOfCashSavings"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_c1ac0824-6490-44e8-91be-ca28ad9813a7" xlink:to="loc_vtvt_PercentageOfAmountOfCashSavings_dd1f537e-513a-4364-be2e-37efd891ba8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/IncomeTaxes" xlink:type="simple" xlink:href="vtvt-20220630.xsd#IncomeTaxes"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/IncomeTaxes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_f2895377-23ac-4378-9255-70cd0d8f5d99" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_d4fb8db3-cc57-4e98-ba1b-76c2c875ad07" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_f2895377-23ac-4378-9255-70cd0d8f5d99" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_d4fb8db3-cc57-4e98-ba1b-76c2c875ad07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/IncomeTaxesAdditionalInformationDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#IncomeTaxesAdditionalInformationDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/IncomeTaxesAdditionalInformationDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_728ea365-e4d3-4b40-ba10-104767fb8562" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_IncomeTaxesTable_da987760-472b-465e-94d5-b693671a6bfe" xlink:href="vtvt-20220630.xsd#vtvt_IncomeTaxesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_728ea365-e4d3-4b40-ba10-104767fb8562" xlink:to="loc_vtvt_IncomeTaxesTable_da987760-472b-465e-94d5-b693671a6bfe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_e027803b-48d0-45ea-85cf-d91a2ab0ee97" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_IncomeTaxesTable_da987760-472b-465e-94d5-b693671a6bfe" xlink:to="loc_dei_LegalEntityAxis_e027803b-48d0-45ea-85cf-d91a2ab0ee97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_7416f389-d76d-4ab3-b606-c0c9ba4d054e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_e027803b-48d0-45ea-85cf-d91a2ab0ee97" xlink:to="loc_dei_EntityDomain_7416f389-d76d-4ab3-b606-c0c9ba4d054e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_MFTTPHoldingsLLCMember_b4fc70de-6b50-4fb2-9dba-df98d1e4f04b" xlink:href="vtvt-20220630.xsd#vtvt_MFTTPHoldingsLLCMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_7416f389-d76d-4ab3-b606-c0c9ba4d054e" xlink:to="loc_vtvt_MFTTPHoldingsLLCMember_b4fc70de-6b50-4fb2-9dba-df98d1e4f04b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_IncomeTaxesLineItems_919a0d2a-a5a0-4c17-80bb-8c2e6565a084" xlink:href="vtvt-20220630.xsd#vtvt_IncomeTaxesLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_IncomeTaxesTable_da987760-472b-465e-94d5-b693671a6bfe" xlink:to="loc_vtvt_IncomeTaxesLineItems_919a0d2a-a5a0-4c17-80bb-8c2e6565a084" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_b2436971-792e-4df1-92f7-0ac05a0cd7c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_IncomeTaxesLineItems_919a0d2a-a5a0-4c17-80bb-8c2e6565a084" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_b2436971-792e-4df1-92f7-0ac05a0cd7c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_PercentageOfAmountOfCashSavings_0a10597f-b546-429e-8cab-b8131dd4aced" xlink:href="vtvt-20220630.xsd#vtvt_PercentageOfAmountOfCashSavings"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_IncomeTaxesLineItems_919a0d2a-a5a0-4c17-80bb-8c2e6565a084" xlink:to="loc_vtvt_PercentageOfAmountOfCashSavings_0a10597f-b546-429e-8cab-b8131dd4aced" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/NetLossperShare" xlink:type="simple" xlink:href="vtvt-20220630.xsd#NetLossperShare"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/NetLossperShare" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_ef20e9b1-b73a-4fbc-bd9f-527e85ee6159" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_8e751df4-2f5b-4de8-8f67-77b1e0118920" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_ef20e9b1-b73a-4fbc-bd9f-527e85ee6159" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_8e751df4-2f5b-4de8-8f67-77b1e0118920" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/NetLossperShareTables" xlink:type="simple" xlink:href="vtvt-20220630.xsd#NetLossperShareTables"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/NetLossperShareTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_2180f9cb-6426-481f-92ce-5d4873e7798f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_ac0c30c6-a44b-4d90-9a7c-ef91257dab14" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_2180f9cb-6426-481f-92ce-5d4873e7798f" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_ac0c30c6-a44b-4d90-9a7c-ef91257dab14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_695f4d42-1958-4896-8494-d766e358094b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_2180f9cb-6426-481f-92ce-5d4873e7798f" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_695f4d42-1958-4896-8494-d766e358094b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/NetLossperShareReconciliationoftheNumeratorandDenominatorUsedintheCalculationofBasicandDilutedNetLossperShareofClassACommonStockDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#NetLossperShareReconciliationoftheNumeratorandDenominatorUsedintheCalculationofBasicandDilutedNetLossperShareofClassACommonStockDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/NetLossperShareReconciliationoftheNumeratorandDenominatorUsedintheCalculationofBasicandDilutedNetLossperShareofClassACommonStockDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_597db14a-4794-42d2-970f-20202799fcd4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ScheduleOfEarningsPerShareTable_223da861-bfdc-4442-b873-6aaf35495b1b" xlink:href="vtvt-20220630.xsd#vtvt_ScheduleOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_597db14a-4794-42d2-970f-20202799fcd4" xlink:to="loc_vtvt_ScheduleOfEarningsPerShareTable_223da861-bfdc-4442-b873-6aaf35495b1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_80ba0dc6-bffb-4230-8a5f-8280e5779879" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ScheduleOfEarningsPerShareTable_223da861-bfdc-4442-b873-6aaf35495b1b" xlink:to="loc_us-gaap_StatementClassOfStockAxis_80ba0dc6-bffb-4230-8a5f-8280e5779879" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_948d9771-e69d-4cdf-8e5a-65138d79c661" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_80ba0dc6-bffb-4230-8a5f-8280e5779879" xlink:to="loc_us-gaap_ClassOfStockDomain_948d9771-e69d-4cdf-8e5a-65138d79c661" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_0c93b460-bbc1-4646-85c0-cb570c8ede5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_948d9771-e69d-4cdf-8e5a-65138d79c661" xlink:to="loc_us-gaap_CommonClassAMember_0c93b460-bbc1-4646-85c0-cb570c8ede5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ScheduleOfEarningsPerShareLineItems_cc03e160-b403-4a04-9f27-63a4b25ac3b4" xlink:href="vtvt-20220630.xsd#vtvt_ScheduleOfEarningsPerShareLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ScheduleOfEarningsPerShareTable_223da861-bfdc-4442-b873-6aaf35495b1b" xlink:to="loc_vtvt_ScheduleOfEarningsPerShareLineItems_cc03e160-b403-4a04-9f27-63a4b25ac3b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAbstract_b6744a1b-bfd5-4bea-8bf1-16fdf689fb4e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ScheduleOfEarningsPerShareLineItems_cc03e160-b403-4a04-9f27-63a4b25ac3b4" xlink:to="loc_us-gaap_NetIncomeLossAbstract_b6744a1b-bfd5-4bea-8bf1-16fdf689fb4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_916767cb-63ef-45b9-b7fc-bc61bdeb053a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_b6744a1b-bfd5-4bea-8bf1-16fdf689fb4e" xlink:to="loc_us-gaap_ProfitLoss_916767cb-63ef-45b9-b7fc-bc61bdeb053a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_c5881bd3-7425-4334-8c05-b5f26ea4a9d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_b6744a1b-bfd5-4bea-8bf1-16fdf689fb4e" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_c5881bd3-7425-4334-8c05-b5f26ea4a9d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_d9040e7b-69bb-418e-ba6f-7525febfd88a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_b6744a1b-bfd5-4bea-8bf1-16fdf689fb4e" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_d9040e7b-69bb-418e-ba6f-7525febfd88a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_263caf34-5a35-4390-9036-0e7dac45ee0f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_b6744a1b-bfd5-4bea-8bf1-16fdf689fb4e" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_263caf34-5a35-4390-9036-0e7dac45ee0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_7792a75c-bb6c-401d-b34b-c349facace81" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ScheduleOfEarningsPerShareLineItems_cc03e160-b403-4a04-9f27-63a4b25ac3b4" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_7792a75c-bb6c-401d-b34b-c349facace81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_575cb379-beef-4162-988a-fada2b3c7081" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_7792a75c-bb6c-401d-b34b-c349facace81" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_575cb379-beef-4162-988a-fada2b3c7081" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_b7e22e45-f416-49a8-8635-408b61038807" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_7792a75c-bb6c-401d-b34b-c349facace81" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_b7e22e45-f416-49a8-8635-408b61038807" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_b60bee95-b59c-4312-aa32-db0eeca7a95c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ScheduleOfEarningsPerShareLineItems_cc03e160-b403-4a04-9f27-63a4b25ac3b4" xlink:to="loc_us-gaap_EarningsPerShareBasic_b60bee95-b59c-4312-aa32-db0eeca7a95c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_0c2c36f3-920b-4c78-b957-c9fe8a5361cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_ScheduleOfEarningsPerShareLineItems_cc03e160-b403-4a04-9f27-63a4b25ac3b4" xlink:to="loc_us-gaap_EarningsPerShareDiluted_0c2c36f3-920b-4c78-b957-c9fe8a5361cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/NetLossperShareScheduleofPotentiallyDilutiveSecuritiesnotIncludedinCalculationofDilutedNetLossperShareDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#NetLossperShareScheduleofPotentiallyDilutiveSecuritiesnotIncludedinCalculationofDilutedNetLossperShareDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/NetLossperShareScheduleofPotentiallyDilutiveSecuritiesnotIncludedinCalculationofDilutedNetLossperShareDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_055b6a44-ae4e-4074-923d-9bcd8a02d2a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_2240733c-aaea-4054-96e8-7d1b488eef4f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_055b6a44-ae4e-4074-923d-9bcd8a02d2a8" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_2240733c-aaea-4054-96e8-7d1b488eef4f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_82d1215d-ccc7-41a9-bf02-29dc72f269f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_2240733c-aaea-4054-96e8-7d1b488eef4f" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_82d1215d-ccc7-41a9-bf02-29dc72f269f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1a8adc90-6304-4b1e-b520-8751aa6cc205" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_82d1215d-ccc7-41a9-bf02-29dc72f269f0" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1a8adc90-6304-4b1e-b520-8751aa6cc205" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassBMember_fe751408-32d0-4783-a8ac-0693f4f503dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1a8adc90-6304-4b1e-b520-8751aa6cc205" xlink:to="loc_us-gaap_CommonClassBMember_fe751408-32d0-4783-a8ac-0693f4f503dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_077964a6-34e5-4cf2-8f9a-f62d8210a28c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1a8adc90-6304-4b1e-b520-8751aa6cc205" xlink:to="loc_us-gaap_EmployeeStockOptionMember_077964a6-34e5-4cf2-8f9a-f62d8210a28c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_e59dd019-03a3-48b4-8784-135aaee1fa8b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_1a8adc90-6304-4b1e-b520-8751aa6cc205" xlink:to="loc_us-gaap_WarrantMember_e59dd019-03a3-48b4-8784-135aaee1fa8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_5060b9d2-3605-451d-8c6e-f4fce2c9436e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_2240733c-aaea-4054-96e8-7d1b488eef4f" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_5060b9d2-3605-451d-8c6e-f4fce2c9436e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_01bbb43e-8680-4eb2-90ee-caccf9077773" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_5060b9d2-3605-451d-8c6e-f4fce2c9436e" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_01bbb43e-8680-4eb2-90ee-caccf9077773" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/FairValueofFinancialInstruments" xlink:type="simple" xlink:href="vtvt-20220630.xsd#FairValueofFinancialInstruments"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/FairValueofFinancialInstruments" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_4b61e8f2-759d-4991-95f2-90ad173cf793" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_f6e2f2b0-4f42-42d5-b96d-e8cc0bee91ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_4b61e8f2-759d-4991-95f2-90ad173cf793" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_f6e2f2b0-4f42-42d5-b96d-e8cc0bee91ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/FairValueofFinancialInstrumentsTables" xlink:type="simple" xlink:href="vtvt-20220630.xsd#FairValueofFinancialInstrumentsTables"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/FairValueofFinancialInstrumentsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_0d3cbe68-0f2e-4da0-8c77-45fca75acab6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_4daa9b82-98e2-42b1-b7bc-6fdc9d4c64f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_0d3cbe68-0f2e-4da0-8c77-45fca75acab6" xlink:to="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_4daa9b82-98e2-42b1-b7bc-6fdc9d4c64f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_0525e4fc-08a5-4979-8ae3-05e2132e7927" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_0d3cbe68-0f2e-4da0-8c77-45fca75acab6" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_0525e4fc-08a5-4979-8ae3-05e2132e7927" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_bfeae675-ccda-4991-8058-e10c3fd72a83" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_0d3cbe68-0f2e-4da0-8c77-45fca75acab6" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_bfeae675-ccda-4991-8058-e10c3fd72a83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/FairValueofFinancialInstrumentsSummarizestheConclusionsReachedRegardingFairValueMeasurementsDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#FairValueofFinancialInstrumentsSummarizestheConclusionsReachedRegardingFairValueMeasurementsDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/FairValueofFinancialInstrumentsSummarizestheConclusionsReachedRegardingFairValueMeasurementsDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_1dd750c4-4e2e-4f52-b637-aeed8c5f5ecf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_209a8bf0-3564-48d9-b2a1-1b81ed7b5be2" xlink:href="vtvt-20220630.xsd#vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_1dd750c4-4e2e-4f52-b637-aeed8c5f5ecf" xlink:to="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_209a8bf0-3564-48d9-b2a1-1b81ed7b5be2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_4b0d2bb2-0f46-433f-9864-71b195c13e43" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_209a8bf0-3564-48d9-b2a1-1b81ed7b5be2" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_4b0d2bb2-0f46-433f-9864-71b195c13e43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_4eba95e5-af75-4781-8f07-562ccb2a48f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_4b0d2bb2-0f46-433f-9864-71b195c13e43" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_4eba95e5-af75-4781-8f07-562ccb2a48f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_4c53bb4a-f87d-4db6-9df3-00341ae0bde2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_4eba95e5-af75-4781-8f07-562ccb2a48f5" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_4c53bb4a-f87d-4db6-9df3-00341ae0bde2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_fa3f0c34-3fcc-4e2b-866c-1f451b6088ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_209a8bf0-3564-48d9-b2a1-1b81ed7b5be2" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_fa3f0c34-3fcc-4e2b-866c-1f451b6088ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_080c9714-421b-4ba6-9877-b06b91413321" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_fa3f0c34-3fcc-4e2b-866c-1f451b6088ab" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_080c9714-421b-4ba6-9877-b06b91413321" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_0b283c28-2ee3-4efb-a759-f84f9f321731" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_080c9714-421b-4ba6-9877-b06b91413321" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_0b283c28-2ee3-4efb-a759-f84f9f321731" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_18d9136c-8c00-40b6-9cb4-6bcce3909952" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_080c9714-421b-4ba6-9877-b06b91413321" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_18d9136c-8c00-40b6-9cb4-6bcce3909952" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_cd2f0f53-1d2f-4ebc-9d6c-c2eb52c5d9b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_080c9714-421b-4ba6-9877-b06b91413321" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_cd2f0f53-1d2f-4ebc-9d6c-c2eb52c5d9b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_b53d399e-64da-4fa8-9ebf-4cf44aeb42be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_209a8bf0-3564-48d9-b2a1-1b81ed7b5be2" xlink:to="loc_us-gaap_FinancialInstrumentAxis_b53d399e-64da-4fa8-9ebf-4cf44aeb42be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_4d968d7f-cd21-49a5-a1b6-118147266c17" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_b53d399e-64da-4fa8-9ebf-4cf44aeb42be" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_4d968d7f-cd21-49a5-a1b6-118147266c17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_WarrantLiabilityRelatedPartyMember_30b97e9c-8b97-4833-8f43-307d7236b712" xlink:href="vtvt-20220630.xsd#vtvt_WarrantLiabilityRelatedPartyMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_4d968d7f-cd21-49a5-a1b6-118147266c17" xlink:to="loc_vtvt_WarrantLiabilityRelatedPartyMember_30b97e9c-8b97-4833-8f43-307d7236b712" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_38b8e900-474b-47e0-ba9b-854ccd50c759" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_209a8bf0-3564-48d9-b2a1-1b81ed7b5be2" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_38b8e900-474b-47e0-ba9b-854ccd50c759" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_9a54f4af-fc79-47c7-9245-f1f354e61c57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_38b8e900-474b-47e0-ba9b-854ccd50c759" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_9a54f4af-fc79-47c7-9245-f1f354e61c57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_WarrantLiabilityRelatedPartyMember_fe52108a-ff1d-4f61-bfd4-6d48cbc4ba71" xlink:href="vtvt-20220630.xsd#vtvt_WarrantLiabilityRelatedPartyMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_9a54f4af-fc79-47c7-9245-f1f354e61c57" xlink:to="loc_vtvt_WarrantLiabilityRelatedPartyMember_fe52108a-ff1d-4f61-bfd4-6d48cbc4ba71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems_367f217d-c6fa-49af-8bcc-43cc764e92fe" xlink:href="vtvt-20220630.xsd#vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_209a8bf0-3564-48d9-b2a1-1b81ed7b5be2" xlink:to="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems_367f217d-c6fa-49af-8bcc-43cc764e92fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_0fd0d641-473a-47c1-adeb-020234b00d36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems_367f217d-c6fa-49af-8bcc-43cc764e92fe" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_0fd0d641-473a-47c1-adeb-020234b00d36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_fde7547c-fbb4-4315-8865-2083240edca2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems_367f217d-c6fa-49af-8bcc-43cc764e92fe" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_fde7547c-fbb4-4315-8865-2083240edca2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_52fba435-f454-47f7-b464-045ef28ec4b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems_367f217d-c6fa-49af-8bcc-43cc764e92fe" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_52fba435-f454-47f7-b464-045ef28ec4b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/FairValueofFinancialInstrumentsFairValueLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationDetails" xlink:type="simple" xlink:href="vtvt-20220630.xsd#FairValueofFinancialInstrumentsFairValueLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationDetails"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/FairValueofFinancialInstrumentsFairValueLiabilitiesMeasuredonRecurringBasisUnobservableInputReconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_6069804d-c02f-456a-8d01-0513a78f048a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_6beecf74-4096-4fc7-af06-a3b295128118" xlink:href="vtvt-20220630.xsd#vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_6069804d-c02f-456a-8d01-0513a78f048a" xlink:to="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_6beecf74-4096-4fc7-af06-a3b295128118" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_883350b2-3172-4afa-aeea-0c6bdbeaf08c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_6beecf74-4096-4fc7-af06-a3b295128118" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_883350b2-3172-4afa-aeea-0c6bdbeaf08c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_894e4c6e-3899-401b-b662-10f61db98c1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_883350b2-3172-4afa-aeea-0c6bdbeaf08c" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_894e4c6e-3899-401b-b662-10f61db98c1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_37730270-cd73-453d-a215-3ac6fdb3e56c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_894e4c6e-3899-401b-b662-10f61db98c1f" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_37730270-cd73-453d-a215-3ac6fdb3e56c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_7d383073-0abd-4e27-8792-177e14d6bb57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_6beecf74-4096-4fc7-af06-a3b295128118" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_7d383073-0abd-4e27-8792-177e14d6bb57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_51300e86-e333-46b0-ad7b-ccd5d145dd22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_7d383073-0abd-4e27-8792-177e14d6bb57" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_51300e86-e333-46b0-ad7b-ccd5d145dd22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_WarrantLiabilityRelatedPartyMember_962407d4-1b2a-4db4-a639-cd494e7697fb" xlink:href="vtvt-20220630.xsd#vtvt_WarrantLiabilityRelatedPartyMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_51300e86-e333-46b0-ad7b-ccd5d145dd22" xlink:to="loc_vtvt_WarrantLiabilityRelatedPartyMember_962407d4-1b2a-4db4-a639-cd494e7697fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems_4b6099ef-2bbf-4063-b676-f42577f31055" xlink:href="vtvt-20220630.xsd#vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable_6beecf74-4096-4fc7-af06-a3b295128118" xlink:to="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems_4b6099ef-2bbf-4063-b676-f42577f31055" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8aae0a53-2dd3-41a0-b15f-fe030917f62f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems_4b6099ef-2bbf-4063-b676-f42577f31055" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8aae0a53-2dd3-41a0-b15f-fe030917f62f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_f48b4641-c13d-43f7-b383-b0077d1171dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8aae0a53-2dd3-41a0-b15f-fe030917f62f" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_f48b4641-c13d-43f7-b383-b0077d1171dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputsReconciliationGainLossIncludedInEarnings_c396739b-110d-43db-912b-522d911d9157" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputsReconciliationGainLossIncludedInEarnings"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8aae0a53-2dd3-41a0-b15f-fe030917f62f" xlink:to="loc_us-gaap_FairValueNetDerivativeAssetLiabilityMeasuredOnRecurringBasisUnobservableInputsReconciliationGainLossIncludedInEarnings_c396739b-110d-43db-912b-522d911d9157" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchases_cff7598d-2251-44ec-b48a-6796a72b0495" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchases"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8aae0a53-2dd3-41a0-b15f-fe030917f62f" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityPurchases_cff7598d-2251-44ec-b48a-6796a72b0495" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySales_71e25db2-7bcb-461b-bc82-531e60a8584f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySales"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8aae0a53-2dd3-41a0-b15f-fe030917f62f" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilitySales_71e25db2-7bcb-461b-bc82-531e60a8584f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_3cc94d40-76a4-428d-9ecb-f8c6cfd6ada9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_8aae0a53-2dd3-41a0-b15f-fe030917f62f" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_3cc94d40-76a4-428d-9ecb-f8c6cfd6ada9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/FairValueofFinancialInstrumentsSignificantInputsUtilizedintheValuationofLetterAgreementWarrantsDetail" xlink:type="simple" xlink:href="vtvt-20220630.xsd#FairValueofFinancialInstrumentsSignificantInputsUtilizedintheValuationofLetterAgreementWarrantsDetail"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/FairValueofFinancialInstrumentsSignificantInputsUtilizedintheValuationofLetterAgreementWarrantsDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_e712b977-55c1-45f8-a6fd-a16baed48a08" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_8e9fa377-5498-48c6-a012-d7ac0b1180a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_e712b977-55c1-45f8-a6fd-a16baed48a08" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_8e9fa377-5498-48c6-a012-d7ac0b1180a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_6f7a2d1e-1bfe-48a1-b60c-4d1560e69c00" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_8e9fa377-5498-48c6-a012-d7ac0b1180a9" xlink:to="loc_us-gaap_FinancialInstrumentAxis_6f7a2d1e-1bfe-48a1-b60c-4d1560e69c00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_aa40b469-992b-4fc6-922e-22b9e6aca986" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_6f7a2d1e-1bfe-48a1-b60c-4d1560e69c00" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_aa40b469-992b-4fc6-922e-22b9e6aca986" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_LetterAgreementWarrantsMember_8040e431-bcaf-4b34-b608-9975aca74957" xlink:href="vtvt-20220630.xsd#vtvt_LetterAgreementWarrantsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_aa40b469-992b-4fc6-922e-22b9e6aca986" xlink:to="loc_vtvt_LetterAgreementWarrantsMember_8040e431-bcaf-4b34-b608-9975aca74957" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_16480588-5a67-4e4c-9709-d15733710996" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_8e9fa377-5498-48c6-a012-d7ac0b1180a9" xlink:to="loc_srt_RangeAxis_16480588-5a67-4e4c-9709-d15733710996" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_42eaeda4-e482-4163-9303-0ae3792027b3" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_16480588-5a67-4e4c-9709-d15733710996" xlink:to="loc_srt_RangeMember_42eaeda4-e482-4163-9303-0ae3792027b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_32cd81fe-ae69-47a9-9119-ae8c638fb92c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_42eaeda4-e482-4163-9303-0ae3792027b3" xlink:to="loc_srt_MinimumMember_32cd81fe-ae69-47a9-9119-ae8c638fb92c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_ca899218-f6ee-4c64-849e-1b71dbb20e0e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_42eaeda4-e482-4163-9303-0ae3792027b3" xlink:to="loc_srt_MaximumMember_ca899218-f6ee-4c64-849e-1b71dbb20e0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_WeightedAverageMember_0d50266b-4a87-46de-a1dd-c1549a2d9192" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_WeightedAverageMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_42eaeda4-e482-4163-9303-0ae3792027b3" xlink:to="loc_srt_WeightedAverageMember_0d50266b-4a87-46de-a1dd-c1549a2d9192" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_85807bf8-d15f-49c8-a13e-8bfffc2daa95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_8e9fa377-5498-48c6-a012-d7ac0b1180a9" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_85807bf8-d15f-49c8-a13e-8bfffc2daa95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_3672f41c-67e1-439a-9d5e-094956991510" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_85807bf8-d15f-49c8-a13e-8bfffc2daa95" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_3672f41c-67e1-439a-9d5e-094956991510" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_90612c7c-f03e-4978-b3b0-3c4b919a4675" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputPriceVolatilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_3672f41c-67e1-439a-9d5e-094956991510" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_90612c7c-f03e-4978-b3b0-3c4b919a4675" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_e1cc5594-2231-4e85-aedf-4f8c7e8d43ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_3672f41c-67e1-439a-9d5e-094956991510" xlink:to="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_e1cc5594-2231-4e85-aedf-4f8c7e8d43ba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_0dfc9758-97c1-484f-ba5e-e2b6417e03a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_8e9fa377-5498-48c6-a012-d7ac0b1180a9" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_0dfc9758-97c1-484f-ba5e-e2b6417e03a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingMeasurementInput_022fcef0-b4f2-45da-b35b-635326955e80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantsAndRightsOutstandingMeasurementInput"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_0dfc9758-97c1-484f-ba5e-e2b6417e03a7" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingMeasurementInput_022fcef0-b4f2-45da-b35b-635326955e80" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/SubsequentEvents" xlink:type="simple" xlink:href="vtvt-20220630.xsd#SubsequentEvents"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/SubsequentEvents" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsAbstract_75e57fda-1538-4213-a3d5-26f0967cf27b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsTextBlock_3a938ee0-e6a0-49ef-8d1f-93fab068803d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_75e57fda-1538-4213-a3d5-26f0967cf27b" xlink:to="loc_us-gaap_SubsequentEventsTextBlock_3a938ee0-e6a0-49ef-8d1f-93fab068803d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="vtvt-20220630.xsd#SubsequentEventsDetails"/>
  <link:presentationLink xlink:role="http://vtvtherapeutics.com/role/SubsequentEventsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventsAbstract_6ab8c64d-73bd-4a6c-87e2-23dccef60f94" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_682c06f4-6c6c-42fb-b527-8433c87c4f82" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventsAbstract_6ab8c64d-73bd-4a6c-87e2-23dccef60f94" xlink:to="loc_us-gaap_SubsequentEventTable_682c06f4-6c6c-42fb-b527-8433c87c4f82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_4e3a7a23-ee47-4043-a205-a61caff19626" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_682c06f4-6c6c-42fb-b527-8433c87c4f82" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_4e3a7a23-ee47-4043-a205-a61caff19626" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_11dcda68-e19d-42f3-97dd-e329eb296f1d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_4e3a7a23-ee47-4043-a205-a61caff19626" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_11dcda68-e19d-42f3-97dd-e329eb296f1d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_898622fc-f978-4836-9728-5d64534d79f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_11dcda68-e19d-42f3-97dd-e329eb296f1d" xlink:to="loc_us-gaap_SubsequentEventMember_898622fc-f978-4836-9728-5d64534d79f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_717df4c8-40ca-48bb-9811-1cad270abf06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_682c06f4-6c6c-42fb-b527-8433c87c4f82" xlink:to="loc_us-gaap_StatementClassOfStockAxis_717df4c8-40ca-48bb-9811-1cad270abf06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_78f5876a-7c76-4640-a05f-51a99e04f8db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_717df4c8-40ca-48bb-9811-1cad270abf06" xlink:to="loc_us-gaap_ClassOfStockDomain_78f5876a-7c76-4640-a05f-51a99e04f8db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonClassAMember_674da1df-9747-4d32-b44f-e34492beeaca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_78f5876a-7c76-4640-a05f-51a99e04f8db" xlink:to="loc_us-gaap_CommonClassAMember_674da1df-9747-4d32-b44f-e34492beeaca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingAxis_2768886b-14b2-4c81-ac4d-3463e7a19594" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VestingAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_682c06f4-6c6c-42fb-b527-8433c87c4f82" xlink:to="loc_us-gaap_VestingAxis_2768886b-14b2-4c81-ac4d-3463e7a19594" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingDomain_f1f7ff94-4189-443e-81ee-ab60f4bc61b6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VestingDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VestingAxis_2768886b-14b2-4c81-ac4d-3463e7a19594" xlink:to="loc_us-gaap_VestingDomain_f1f7ff94-4189-443e-81ee-ab60f4bc61b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheOneMember_2905574d-a534-4dd0-84d6-87f0753a20eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationAwardTrancheOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VestingDomain_f1f7ff94-4189-443e-81ee-ab60f4bc61b6" xlink:to="loc_us-gaap_ShareBasedCompensationAwardTrancheOneMember_2905574d-a534-4dd0-84d6-87f0753a20eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_e663fa44-59f9-41d1-b0f8-934c35d661c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationAwardTrancheTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VestingDomain_f1f7ff94-4189-443e-81ee-ab60f4bc61b6" xlink:to="loc_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_e663fa44-59f9-41d1-b0f8-934c35d661c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTable_682c06f4-6c6c-42fb-b527-8433c87c4f82" xlink:to="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_bd017614-7375-4397-968f-b2997cc62588" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_bd017614-7375-4397-968f-b2997cc62588" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_94da4a17-2dca-482f-92e4-059324490a26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_94da4a17-2dca-482f-92e4-059324490a26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_SaleOfStockConsiderationReceivedOnTransactionGross_ed543fa6-6e3a-4d92-bbad-473ab1aa3bf8" xlink:href="vtvt-20220630.xsd#vtvt_SaleOfStockConsiderationReceivedOnTransactionGross"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_vtvt_SaleOfStockConsiderationReceivedOnTransactionGross_ed543fa6-6e3a-4d92-bbad-473ab1aa3bf8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_f0baa3e8-5b88-48ca-8d2f-a5db2821b4aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_f0baa3e8-5b88-48ca-8d2f-a5db2821b4aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_918770af-bb66-46c1-afb4-b6d732b51ca6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_us-gaap_ReceivablesNetCurrent_918770af-bb66-46c1-afb4-b6d732b51ca6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_93555afd-9b94-42e2-a5ae-6566d93e18c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_93555afd-9b94-42e2-a5ae-6566d93e18c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_6cf521f5-ec80-4f7e-96dd-0b6608f1a1cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_6cf521f5-ec80-4f7e-96dd-0b6608f1a1cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_f17e6716-2070-4919-a16b-dde9a080f8a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_f17e6716-2070-4919-a16b-dde9a080f8a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPerShareWeightedAveragePriceOfSharesPurchased_cfc13cd0-1eef-4259-b9b7-1f6896e48d88" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPerShareWeightedAveragePriceOfSharesPurchased"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPerShareWeightedAveragePriceOfSharesPurchased_cfc13cd0-1eef-4259-b9b7-1f6896e48d88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_22f29707-2c41-4289-8033-8177fdb63df0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_22f29707-2c41-4289-8033-8177fdb63df0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_581fb49b-e02b-42d4-9f1f-c9077c7ca68b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_581fb49b-e02b-42d4-9f1f-c9077c7ca68b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_c45cacf8-8572-4f68-a28f-52a37a5873ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventLineItems_38323ac7-ea0e-4261-a472-6197f31c2b06" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_c45cacf8-8572-4f68-a28f-52a37a5873ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
