<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:4936e01c-e624-406c-8120-c522dc93cb6e,g:721c95b8-cc21-49e6-99fa-824bb7f64fa5-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="vtvt-20220930.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://vtvtherapeutics.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_d18f9ce5-8e7f-4fe6-901f-87c15fe58f0d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_c2748ba1-e5ee-4e04-8105-8d9f6e9e4809" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_d18f9ce5-8e7f-4fe6-901f-87c15fe58f0d" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_c2748ba1-e5ee-4e04-8105-8d9f6e9e4809" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_04155faf-2434-4e34-87ae-4ba1e6d95d8f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_d18f9ce5-8e7f-4fe6-901f-87c15fe58f0d" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_04155faf-2434-4e34-87ae-4ba1e6d95d8f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_d014ecd5-f7d8-464b-829a-499f2504daa7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_d18f9ce5-8e7f-4fe6-901f-87c15fe58f0d" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_d014ecd5-f7d8-464b-829a-499f2504daa7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableCurrent_db01fa51-db7e-4147-be33-1e76bae8501b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesPayableCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_d18f9ce5-8e7f-4fe6-901f-87c15fe58f0d" xlink:to="loc_us-gaap_NotesPayableCurrent_db01fa51-db7e-4147-be33-1e76bae8501b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_1390ca9c-0741-450c-b664-b1ac1cefcec3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_2ff5b464-4953-4278-a1e9-51809bdb2f55" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_1390ca9c-0741-450c-b664-b1ac1cefcec3" xlink:to="loc_us-gaap_AssetsCurrent_2ff5b464-4953-4278-a1e9-51809bdb2f55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_61e3c8b1-fae6-48a4-9f4b-89367a613888" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_1390ca9c-0741-450c-b664-b1ac1cefcec3" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_61e3c8b1-fae6-48a4-9f4b-89367a613888" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_55cac8e1-3f13-420d-97cb-8a79d735471c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_1390ca9c-0741-450c-b664-b1ac1cefcec3" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_55cac8e1-3f13-420d-97cb-8a79d735471c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_b44d12b0-70ae-4276-a4ac-2021ac83b239" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermInvestments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_1390ca9c-0741-450c-b664-b1ac1cefcec3" xlink:to="loc_us-gaap_LongTermInvestments_b44d12b0-70ae-4276-a4ac-2021ac83b239" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_b1cd3ffb-c8fc-433e-aec6-5ea33fc02198" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_cca9f1d6-845b-4da4-8a0e-688d08e65b28" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_b1cd3ffb-c8fc-433e-aec6-5ea33fc02198" xlink:to="loc_us-gaap_Liabilities_cca9f1d6-845b-4da4-8a0e-688d08e65b28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_2244b252-79de-49be-b329-6c240e20f9ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_b1cd3ffb-c8fc-433e-aec6-5ea33fc02198" xlink:to="loc_us-gaap_CommitmentsAndContingencies_2244b252-79de-49be-b329-6c240e20f9ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount_60a74334-093e-4191-b14d-ce5d8bfcdcd3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_b1cd3ffb-c8fc-433e-aec6-5ea33fc02198" xlink:to="loc_us-gaap_RedeemableNoncontrollingInterestEquityCarryingAmount_60a74334-093e-4191-b14d-ce5d8bfcdcd3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_2dc46230-a589-49c4-a0a0-547b0aa4faa8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_b1cd3ffb-c8fc-433e-aec6-5ea33fc02198" xlink:to="loc_us-gaap_StockholdersEquity_2dc46230-a589-49c4-a0a0-547b0aa4faa8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_c74dabd2-2dd1-4b78-b2be-878e821f71d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DueToRelatedPartiesNoncurrent_46f836f0-6d70-45f6-a244-aa0fe3a3ff0b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DueToRelatedPartiesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_c74dabd2-2dd1-4b78-b2be-878e821f71d6" xlink:to="loc_us-gaap_DueToRelatedPartiesNoncurrent_46f836f0-6d70-45f6-a244-aa0fe3a3ff0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_fd8f5bb4-74c4-42db-9fbc-12b2daee9861" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_c74dabd2-2dd1-4b78-b2be-878e821f71d6" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_fd8f5bb4-74c4-42db-9fbc-12b2daee9861" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_e72eb86a-2d72-4984-9de8-d104518f222d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_c74dabd2-2dd1-4b78-b2be-878e821f71d6" xlink:to="loc_us-gaap_LiabilitiesCurrent_e72eb86a-2d72-4984-9de8-d104518f222d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_c8ea57ca-46bd-49be-8c60-0a2961fc438d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_c74dabd2-2dd1-4b78-b2be-878e821f71d6" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_c8ea57ca-46bd-49be-8c60-0a2961fc438d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_97ee8668-88f9-4ec9-b9b6-763196e2c95e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_63b9602c-cfe0-4a7c-b4d7-0d143cfece85" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_97ee8668-88f9-4ec9-b9b6-763196e2c95e" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_63b9602c-cfe0-4a7c-b4d7-0d143cfece85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_57d3f834-f4bd-4a7d-8f38-3658c1f1b7b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_97ee8668-88f9-4ec9-b9b6-763196e2c95e" xlink:to="loc_us-gaap_CommonStockValue_57d3f834-f4bd-4a7d-8f38-3658c1f1b7b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_321d9ea3-f503-4157-ac72-ee683513c7d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_97ee8668-88f9-4ec9-b9b6-763196e2c95e" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_321d9ea3-f503-4157-ac72-ee683513c7d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteSubscriptionsReceivable_14706645-db32-454e-ae10-651396237bd7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteSubscriptionsReceivable"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_97ee8668-88f9-4ec9-b9b6-763196e2c95e" xlink:to="loc_us-gaap_StockholdersEquityNoteSubscriptionsReceivable_14706645-db32-454e-ae10-651396237bd7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_ede005f2-c0fa-4784-b344-d45d6281132d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsAssetsCurrent_333366e4-796b-4be0-891f-c4765069678f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsAssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ede005f2-c0fa-4784-b344-d45d6281132d" xlink:to="loc_us-gaap_DepositsAssetsCurrent_333366e4-796b-4be0-891f-c4765069678f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a457ec8c-9775-4e23-94e3-fb0dd690634b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ede005f2-c0fa-4784-b344-d45d6281132d" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a457ec8c-9775-4e23-94e3-fb0dd690634b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_091950db-5bac-46ab-aa72-45919c7765c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ede005f2-c0fa-4784-b344-d45d6281132d" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_091950db-5bac-46ab-aa72-45919c7765c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_38a3fe72-f7e4-428c-87b8-7c3d2e876ab3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ede005f2-c0fa-4784-b344-d45d6281132d" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_38a3fe72-f7e4-428c-87b8-7c3d2e876ab3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_NotesReceivableCurrent_f359bba1-8224-4e8e-90fd-dca6afeca785" xlink:href="vtvt-20220930.xsd#vtvt_NotesReceivableCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_ede005f2-c0fa-4784-b344-d45d6281132d" xlink:to="loc_vtvt_NotesReceivableCurrent_f359bba1-8224-4e8e-90fd-dca6afeca785" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CondensedConsolidatedStatementsofOperationsUnaudited" xlink:type="simple" xlink:href="vtvt-20220930.xsd#CondensedConsolidatedStatementsofOperationsUnaudited"/>
  <link:calculationLink xlink:role="http://vtvtherapeutics.com/role/CondensedConsolidatedStatementsofOperationsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_c4124a2a-504e-4fd6-a17f-1b4add6013cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_09e908a9-24b2-4a87-be2e-1e080c23d93b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_c4124a2a-504e-4fd6-a17f-1b4add6013cb" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_09e908a9-24b2-4a87-be2e-1e080c23d93b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_8ea3bbeb-fc51-4d31-806b-a69584642929" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_c4124a2a-504e-4fd6-a17f-1b4add6013cb" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_8ea3bbeb-fc51-4d31-806b-a69584642929" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_641ac219-795d-4a80-b409-69ee8b39b78c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_bbc55b6f-ba1e-405b-b34b-867f30b46303" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_641ac219-795d-4a80-b409-69ee8b39b78c" xlink:to="loc_us-gaap_OperatingIncomeLoss_bbc55b6f-ba1e-405b-b34b-867f30b46303" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_OtherIncomeExpensesRelatedParty_1b2f1aac-aa69-4d00-a669-d89c68c60d93" xlink:href="vtvt-20220930.xsd#vtvt_OtherIncomeExpensesRelatedParty"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_641ac219-795d-4a80-b409-69ee8b39b78c" xlink:to="loc_vtvt_OtherIncomeExpensesRelatedParty_1b2f1aac-aa69-4d00-a669-d89c68c60d93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_4d94b5ff-8395-4ef4-bdb4-67079f807344" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_641ac219-795d-4a80-b409-69ee8b39b78c" xlink:to="loc_us-gaap_InvestmentIncomeInterest_4d94b5ff-8395-4ef4-bdb4-67079f807344" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_57f4ee45-0b5f-4f83-8090-fed8568098d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_641ac219-795d-4a80-b409-69ee8b39b78c" xlink:to="loc_us-gaap_InterestExpense_57f4ee45-0b5f-4f83-8090-fed8568098d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_4b215242-6a66-4c8d-af84-279cc885ea03" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_641ac219-795d-4a80-b409-69ee8b39b78c" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_4b215242-6a66-4c8d-af84-279cc885ea03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_e1e9d46e-3ddc-4570-8449-653374af07f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_c96f1136-2b2d-42b1-bbff-a3ca025e789d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_e1e9d46e-3ddc-4570-8449-653374af07f2" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_c96f1136-2b2d-42b1-bbff-a3ca025e789d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_b9c04747-4910-4721-81ea-ed8b835b5748" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_e1e9d46e-3ddc-4570-8449-653374af07f2" xlink:to="loc_us-gaap_OperatingExpenses_b9c04747-4910-4721-81ea-ed8b835b5748" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_d7e762f3-9fae-4965-9234-a65211b6d220" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_c24881d2-9eb2-473a-abc4-97bc192d287b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_d7e762f3-9fae-4965-9234-a65211b6d220" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_c24881d2-9eb2-473a-abc4-97bc192d287b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_c26a8d3c-1544-49d6-9f6a-9215c5d555ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_d7e762f3-9fae-4965-9234-a65211b6d220" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_c26a8d3c-1544-49d6-9f6a-9215c5d555ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_d2875f2f-1395-444a-8d64-ec05e6c69169" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_d0b0b7a7-70a6-4c14-a147-f2343962b0d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_d2875f2f-1395-444a-8d64-ec05e6c69169" xlink:to="loc_us-gaap_ProfitLoss_d0b0b7a7-70a6-4c14-a147-f2343962b0d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_7f7468fd-f251-4cca-b135-a288d1829578" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_d2875f2f-1395-444a-8d64-ec05e6c69169" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_7f7468fd-f251-4cca-b135-a288d1829578" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="simple" xlink:href="vtvt-20220930.xsd#CondensedConsolidatedStatementsofCashFlowsUnaudited"/>
  <link:calculationLink xlink:role="http://vtvtherapeutics.com/role/CondensedConsolidatedStatementsofCashFlowsUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d98ea03b-d110-42aa-b838-8935246ec761" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0a7ef8e9-1532-4556-9e51-bb61a40c6179" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d98ea03b-d110-42aa-b838-8935246ec761" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0a7ef8e9-1532-4556-9e51-bb61a40c6179" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_92349a88-4b29-478c-8d33-b66f6133d783" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d98ea03b-d110-42aa-b838-8935246ec761" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_92349a88-4b29-478c-8d33-b66f6133d783" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f7003cc7-b983-4eb9-85d3-a8ceab5e6f6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_d98ea03b-d110-42aa-b838-8935246ec761" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_f7003cc7-b983-4eb9-85d3-a8ceab5e6f6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ce7a0e2d-bc93-46c7-97f8-4e253272754d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockPreferenceStockAndWarrants_8395bc50-ba08-42ab-8b6b-f70b79eb1f2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfPreferredStockPreferenceStockAndWarrants"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ce7a0e2d-bc93-46c7-97f8-4e253272754d" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPreferredStockPreferenceStockAndWarrants_8395bc50-ba08-42ab-8b6b-f70b79eb1f2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfNotesPayable_367dfab6-dfc7-481b-bdbc-5943d5ea8fce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfNotesPayable"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ce7a0e2d-bc93-46c7-97f8-4e253272754d" xlink:to="loc_us-gaap_RepaymentsOfNotesPayable_367dfab6-dfc7-481b-bdbc-5943d5ea8fce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_ec521b36-9b26-4d96-accd-8c1aba8c1485" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ce7a0e2d-bc93-46c7-97f8-4e253272754d" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_ec521b36-9b26-4d96-accd-8c1aba8c1485" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_e0d1a58e-7412-413c-9d67-5bc2a399340b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ce7a0e2d-bc93-46c7-97f8-4e253272754d" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_e0d1a58e-7412-413c-9d67-5bc2a399340b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ProceedsFromSaleOfCommonStock_7ca6b755-eb12-4c9c-921d-336973e8cd5d" xlink:href="vtvt-20220930.xsd#vtvt_ProceedsFromSaleOfCommonStock"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ce7a0e2d-bc93-46c7-97f8-4e253272754d" xlink:to="loc_vtvt_ProceedsFromSaleOfCommonStock_7ca6b755-eb12-4c9c-921d-336973e8cd5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_aeaecb2d-04d7-4bc2-8ef6-bf1401ba7bc8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_ce7a0e2d-bc93-46c7-97f8-4e253272754d" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_aeaecb2d-04d7-4bc2-8ef6-bf1401ba7bc8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_3958e1f4-4798-4b5e-9c3e-c911d9287cad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:to="loc_us-gaap_ProfitLoss_3958e1f4-4798-4b5e-9c3e-c911d9287cad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ChangeInFairValueOfWarrantsRelatedParty_dab8d6e2-1d27-4735-a3ec-2183b51e1230" xlink:href="vtvt-20220930.xsd#vtvt_ChangeInFairValueOfWarrantsRelatedParty"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:to="loc_vtvt_ChangeInFairValueOfWarrantsRelatedParty_dab8d6e2-1d27-4735-a3ec-2183b51e1230" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_90d279b8-00da-4544-a85a-92a2559c487b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:to="loc_us-gaap_ShareBasedCompensation_90d279b8-00da-4544-a85a-92a2559c487b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_3ee5b41a-963d-43af-85c5-2978ff6aba92" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_3ee5b41a-963d-43af-85c5-2978ff6aba92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_23b266b5-1496-4872-abe6-3d8e69b6437d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Depreciation"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:to="loc_us-gaap_Depreciation_23b266b5-1496-4872-abe6-3d8e69b6437d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_6349620e-1bfd-44e6-a3b1-f1c775c34202" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_6349620e-1bfd-44e6-a3b1-f1c775c34202" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_6373f7fe-3282-441c-b8e5-fca21541ddc6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_6373f7fe-3282-441c-b8e5-fca21541ddc6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseOther_b6a13938-68e6-4ffa-b083-75c660b83e80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpenseOther"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:to="loc_us-gaap_InterestExpenseOther_b6a13938-68e6-4ffa-b083-75c660b83e80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments_76119cfa-89cf-4baf-9481-fc42e9923dcb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrealizedGainLossOnInvestments"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestments_76119cfa-89cf-4baf-9481-fc42e9923dcb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_d4aa1e93-5c61-4efd-a6da-a8b641a3e728" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_d4aa1e93-5c61-4efd-a6da-a8b641a3e728" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOperating_5c9c95ca-b819-464d-b128-c2a368b291e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeOperating"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_a834d0fd-0900-495c-a980-35641b414058" xlink:to="loc_us-gaap_InterestIncomeOperating_5c9c95ca-b819-464d-b128-c2a368b291e2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9f8449ff-69b1-455d-9be6-98b18d8968d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_163409fc-817f-4710-9c87-d1acf6fc9c79" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9f8449ff-69b1-455d-9be6-98b18d8968d0" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_163409fc-817f-4710-9c87-d1acf6fc9c79" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail" xlink:type="simple" xlink:href="vtvt-20220930.xsd#LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail"/>
  <link:calculationLink xlink:role="http://vtvtherapeutics.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_3456d795-90ad-47bb-b7b5-c6745c24b4c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_a62dac1a-4e1a-422b-9dbc-6c59a9774dae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_3456d795-90ad-47bb-b7b5-c6745c24b4c5" xlink:to="loc_us-gaap_OperatingLeaseLiability_a62dac1a-4e1a-422b-9dbc-6c59a9774dae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_OperatingLeasesImputedInterest_0426b276-d0c2-4ece-8504-268db85b125f" xlink:href="vtvt-20220930.xsd#vtvt_OperatingLeasesImputedInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_3456d795-90ad-47bb-b7b5-c6745c24b4c5" xlink:to="loc_vtvt_OperatingLeasesImputedInterest_0426b276-d0c2-4ece-8504-268db85b125f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail_1" xlink:type="simple" xlink:href="vtvt-20220930.xsd#LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail_1"/>
  <link:calculationLink xlink:role="http://vtvtherapeutics.com/role/LeasesScheduleofMaturitiesofLeaseLiabilitiesforOperatingLeasesDetail_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e1f5b928-f787-4394-b1c1-3464f45d6372" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_83c87a40-dee7-4c50-9b87-675d98f23564" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e1f5b928-f787-4394-b1c1-3464f45d6372" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_83c87a40-dee7-4c50-9b87-675d98f23564" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_02c16794-e5c4-4b14-82ce-a505b9b48312" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e1f5b928-f787-4394-b1c1-3464f45d6372" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_02c16794-e5c4-4b14-82ce-a505b9b48312" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_d52e096a-e63d-4972-b13f-180b2d925dd2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e1f5b928-f787-4394-b1c1-3464f45d6372" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_d52e096a-e63d-4972-b13f-180b2d925dd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_5247684e-9c79-42bc-baf2-1602069ae6c0" xlink:href="vtvt-20220930.xsd#vtvt_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e1f5b928-f787-4394-b1c1-3464f45d6372" xlink:to="loc_vtvt_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_5247684e-9c79-42bc-baf2-1602069ae6c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_83de4749-33b0-4aec-8ccf-032363abd7da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e1f5b928-f787-4394-b1c1-3464f45d6372" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_83de4749-33b0-4aec-8ccf-032363abd7da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_9f255fa2-5f6a-48ba-9116-e74aa7b3deac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_e1f5b928-f787-4394-b1c1-3464f45d6372" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_9f255fa2-5f6a-48ba-9116-e74aa7b3deac" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/RedeemableNoncontrollingInterestSummaryofNetIncomeAttributabletoVtvTherapeuticsIncDetail" xlink:type="simple" xlink:href="vtvt-20220930.xsd#RedeemableNoncontrollingInterestSummaryofNetIncomeAttributabletoVtvTherapeuticsIncDetail"/>
  <link:calculationLink xlink:role="http://vtvtherapeutics.com/role/RedeemableNoncontrollingInterestSummaryofNetIncomeAttributabletoVtvTherapeuticsIncDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangeDueToNetIncomeAttributableToParentAndEffectsOfChangesNet_7cf7c530-cded-4ad0-976c-c5564d3feb06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangeDueToNetIncomeAttributableToParentAndEffectsOfChangesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_b076221f-eeee-4bb4-9295-667590e85ad4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangeDueToNetIncomeAttributableToParentAndEffectsOfChangesNet_7cf7c530-cded-4ad0-976c-c5564d3feb06" xlink:to="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_b076221f-eeee-4bb4-9295-667590e85ad4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_vtvt_ConsolidationChangesWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParent_e8dbf151-6605-4f9a-9bd5-8dc74a280abb" xlink:href="vtvt-20220930.xsd#vtvt_ConsolidationChangesWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangeDueToNetIncomeAttributableToParentAndEffectsOfChangesNet_7cf7c530-cded-4ad0-976c-c5564d3feb06" xlink:to="loc_vtvt_ConsolidationChangesWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParent_e8dbf151-6605-4f9a-9bd5-8dc74a280abb" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/NetLossperShareReconciliationoftheNumeratorandDenominatorUsedintheCalculationofBasicandDilutedNetLossperShareofClassACommonStockDetail" xlink:type="simple" xlink:href="vtvt-20220930.xsd#NetLossperShareReconciliationoftheNumeratorandDenominatorUsedintheCalculationofBasicandDilutedNetLossperShareofClassACommonStockDetail"/>
  <link:calculationLink xlink:role="http://vtvtherapeutics.com/role/NetLossperShareReconciliationoftheNumeratorandDenominatorUsedintheCalculationofBasicandDilutedNetLossperShareofClassACommonStockDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_102763d3-24b1-477c-8003-ec618643ae5d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_624f2b76-6080-4211-a45e-878a37a27b29" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_102763d3-24b1-477c-8003-ec618643ae5d" xlink:to="loc_us-gaap_ProfitLoss_624f2b76-6080-4211-a45e-878a37a27b29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_f6b31a5c-f00d-4086-82c9-fdab70b1d0e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_102763d3-24b1-477c-8003-ec618643ae5d" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_f6b31a5c-f00d-4086-82c9-fdab70b1d0e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_8ab1985f-8944-44df-a501-30867282d705" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_ba0029a5-30c8-4c39-978a-75d4e1e604f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_8ab1985f-8944-44df-a501-30867282d705" xlink:to="loc_us-gaap_ProfitLoss_ba0029a5-30c8-4c39-978a-75d4e1e604f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_368d431a-af14-44d6-bfdb-7d4dcc39c185" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLossAvailableToCommonStockholdersDiluted_8ab1985f-8944-44df-a501-30867282d705" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_368d431a-af14-44d6-bfdb-7d4dcc39c185" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://vtvtherapeutics.com/role/FairValueofFinancialInstrumentsSummarizestheConclusionsReachedRegardingFairValueMeasurementsDetail" xlink:type="simple" xlink:href="vtvt-20220930.xsd#FairValueofFinancialInstrumentsSummarizestheConclusionsReachedRegardingFairValueMeasurementsDetail"/>
  <link:calculationLink xlink:role="http://vtvtherapeutics.com/role/FairValueofFinancialInstrumentsSummarizestheConclusionsReachedRegardingFairValueMeasurementsDetail" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_c3c9df60-0fea-493c-90f0-6b36df752a2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_2cc13500-a763-41d6-87d7-5be6eabdc132" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_c3c9df60-0fea-493c-90f0-6b36df752a2e" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_2cc13500-a763-41d6-87d7-5be6eabdc132" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
