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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2021-02-24T14:47:54.6375550+00:00 -->
<!-- Version            : 5.0.1.571 -->
<!-- Package ID         : dfbb8b3997c14d7eb1640b4d84811c3e -->
<!-- Copyright (c) 2021 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="vtvt_StockIssuedDuringPeriodUnderDirectOfferingValue" name="StockIssuedDuringPeriodUnderDirectOfferingValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_StockIssuedDuringPeriodUnderDirectOfferingShares" name="StockIssuedDuringPeriodUnderDirectOfferingShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_StockIssuedDuringPeriodValueVestingOfRestrictedStockUnits" name="StockIssuedDuringPeriodValueVestingOfRestrictedStockUnits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_IssuanceOfClassACommonStockUnderATMOffering" name="IssuanceOfClassACommonStockUnderATMOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_IssuanceOfClassACommonStockUnderATMOfferingShares" name="IssuanceOfClassACommonStockUnderATMOfferingShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_IssuanceOfClassACommonStockUnderLPCAgreement" name="IssuanceOfClassACommonStockUnderLPCAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_IssuanceOfClassACommonStockUnderLPCAgreementShares" name="IssuanceOfClassACommonStockUnderLPCAgreementShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_RedeemableNoncontrollingInterestsMember" name="RedeemableNoncontrollingInterestsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_ChangeInFairValueOfInvestments" name="ChangeInFairValueOfInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_ChangeInFairValueOfWarrantsRelatedParty" name="ChangeInFairValueOfWarrantsRelatedParty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_IncreaseDecreaseInLongTermDeposits" name="IncreaseDecreaseInLongTermDeposits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_AccretedInterestOnDebt" name="AccretedInterestOnDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_ProceedsFromIssuanceOfCommonStockToRelatedParty" name="ProceedsFromIssuanceOfCommonStockToRelatedParty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_LeaseholdImprovementsObtainedInExchangeForLeaseObligations" name="LeaseholdImprovementsObtainedInExchangeForLeaseObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_CollaborationRevenueAndAccountsReceivablePolicyTextBlock" name="CollaborationRevenueAndAccountsReceivablePolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_PatentCostsPolicyTextBlock" name="PatentCostsPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_NoncontrollingInterestPolicyPolicyTextBlock" name="NoncontrollingInterestPolicyPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_PropertyAndEquipmentEstimatedUsefulLivesTableTextBlock" name="PropertyAndEquipmentEstimatedUsefulLivesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_PercentageOfNonVotingEconomicInterest" name="PercentageOfNonVotingEconomicInterest" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_PercentageOfNonVotingEconomicInterestByParent" name="PercentageOfNonVotingEconomicInterestByParent" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_VariableInterestsAndEquityMethodInvestmentsDisclosureAbstract" name="VariableInterestsAndEquityMethodInvestmentsDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems" name="OrganizationConsolidationAndPresentationOfFinancialStatementsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_OrganizationConsolidationAndPresentationOfFinancialStatementsTable" name="OrganizationConsolidationAndPresentationOfFinancialStatementsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_VTvLLCMember" name="VTvLLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_LicenseAgreementObligationsAxis" name="LicenseAgreementObligationsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_LicenseAgreementObligationsDomain" name="LicenseAgreementObligationsDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_LPCPurchaseAgreementMember" name="LPCPurchaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_ATMOfferingMember" name="ATMOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_NumberOfRegisteredSharesAvailableUnderLPCPurchaseAgreement" name="NumberOfRegisteredSharesAvailableUnderLPCPurchaseAgreement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_AggregateOfferingPriceOfShares" name="AggregateOfferingPriceOfShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_NumberOfCustomers" name="NumberOfCustomers" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_SummaryOfSignificantAccountingPoliciesLineItems" name="SummaryOfSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_LicenseFeeReceived" name="LicenseFeeReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_PotentialDevelopmentAndRegulatoryMilestonePaymentsReceivable" name="PotentialDevelopmentAndRegulatoryMilestonePaymentsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_ReneoPharmaceuticalsIncMember" name="ReneoPharmaceuticalsIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_HangzhouZhongmeiHuadongPharmaceuticalCompanyLimitedMember" name="HangzhouZhongmeiHuadongPharmaceuticalCompanyLimitedMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_PhaseTwoMultiRegionalClinicalTrialMember" name="PhaseTwoMultiRegionalClinicalTrialMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_LicenseAndTechnologyTransferServicesOfChemistryAndManufacturingKnowHowMember" name="LicenseAndTechnologyTransferServicesOfChemistryAndManufacturingKnowHowMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_ObligationToSponsorAndConductPortionOfPhase2MRCTMember" name="ObligationToSponsorAndConductPortionOfPhase2MRCTMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_JointDevelopmentCommitteeMember" name="JointDevelopmentCommitteeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_NewsoaraBiopharmaCoLtdMember" name="NewsoaraBiopharmaCoLtdMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_AnterisBioIncMember" name="AnterisBioIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_JDRFInternationalMember" name="JDRFInternationalMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_PotentialRegulatoryMilestonePaymentsReceivableUponRegulatoryApproval" name="PotentialRegulatoryMilestonePaymentsReceivableUponRegulatoryApproval" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_PotentialSalesMilestonePaymentsReceivable" name="PotentialSalesMilestonePaymentsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_MaximumSponsoringContributionAmount" name="MaximumSponsoringContributionAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_AdjustmentsToTransactionPriceForPerformanceObligations" name="AdjustmentsToTransactionPriceForPerformanceObligations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_MaximumResearchFundingReceivableBasedOnAchievementOfResearchAndDevelopmentMilestones" name="MaximumResearchFundingReceivableBasedOnAchievementOfResearchAndDevelopmentMilestones" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_MaximumFundingPercentageOfResearchAndDevelopmentMilestones" name="MaximumFundingPercentageOfResearchAndDevelopmentMilestones" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_FundingReceived" name="FundingReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_TwoThousandFifteenOmnibusEquityIncentivePlanMember" name="TwoThousandFifteenOmnibusEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_ScheduleOfShareBasedCompensationValuationAssumptionsLineItems" name="ScheduleOfShareBasedCompensationValuationAssumptionsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_ScheduleOfShareBasedCompensationValuationAssumptionsTable" name="ScheduleOfShareBasedCompensationValuationAssumptionsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestOutstandingNumber" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestOutstandingNumber" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="vtvt_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="vtvt_InvestmentOwnershipPercentage" name="InvestmentOwnershipPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="vtvt_AccruedDevelopmentCostsCurrent" name="AccruedDevelopmentCostsCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_AccruedCompensationAndRelatedCosts" name="AccruedCompensationAndRelatedCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_LoanAndSecurityAgreementMember" name="LoanAndSecurityAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_HorizonTechnologyFinanceCorporationAndSiliconValleyBankMember" name="HorizonTechnologyFinanceCorporationAndSiliconValleyBankMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_DebtInstrumentTrancheOneMember" name="DebtInstrumentTrancheOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_DebtInstrumentTrancheTwoMember" name="DebtInstrumentTrancheTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_DebtInstrumentTrancheOneAndTwoMember" name="DebtInstrumentTrancheOneAndTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_DebtInstrumentTrancheThreeMember" name="DebtInstrumentTrancheThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_InterestRateFloor" name="InterestRateFloor" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_WarrantsSharesIssuedPercentageOfLoanAmount" name="WarrantsSharesIssuedPercentageOfLoanAmount" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_WarrantExercisePriceDescription" name="WarrantExercisePriceDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_WarrantsExpirationPeriod" name="WarrantsExpirationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_IssuanceOfWarrantsToPurchaseOfCommonStock" name="IssuanceOfWarrantsToPurchaseOfCommonStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_AnnualFeesUnderAgreement" name="AnnualFeesUnderAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_PaymentOfAnnualFeesDescription" name="PaymentOfAnnualFeesDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_PotentialMilestonePayment" name="PotentialMilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_CommitmentsAndContingenciesLineItems" name="CommitmentsAndContingenciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_CommitmentsAndContingenciesTable" name="CommitmentsAndContingenciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_ColumbiaUniversityMember" name="ColumbiaUniversityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_RegulatoryMilestonePaymentMember" name="RegulatoryMilestonePaymentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_DevelopmentalAndRegulatoryMilestonePaymentMember" name="DevelopmentalAndRegulatoryMilestonePaymentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_SalesBasedMilestonesPaymentMember" name="SalesBasedMilestonesPaymentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_NovoLicenseAgreementMember" name="NovoLicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_OtherIndicationMember" name="OtherIndicationMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_TypeOneDiabetesMember" name="TypeOneDiabetesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_TypeTwoDiabetesMember" name="TypeTwoDiabetesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_CantorFitzgeraldMember" name="CantorFitzgeraldMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_AtTheMarketOfferingMember" name="AtTheMarketOfferingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_RegularPurchaseShareLimitOneMember" name="RegularPurchaseShareLimitOneMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_RegularPurchaseShareLimitTwoMember" name="RegularPurchaseShareLimitTwoMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_RegularPurchaseShareLimitThreeMember" name="RegularPurchaseShareLimitThreeMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_AdditionalAcceleratedMember" name="AdditionalAcceleratedMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_LincolnParkCapitalFundLLCAndAffiliatesMember" name="LincolnParkCapitalFundLLCAndAffiliatesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_ExchangeCapMember" name="ExchangeCapMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_CommonStockNumberOfVotesPerShare" name="CommonStockNumberOfVotesPerShare" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_ProceedsFromIssuanceOfCommonStockGross" name="ProceedsFromIssuanceOfCommonStockGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_SharesRegisteredUnderTheLPCAgreement" name="SharesRegisteredUnderTheLPCAgreement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="vtvt_PercentageOfAggregateOfferingPrice" name="PercentageOfAggregateOfferingPrice" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_SaleOfStockNumberOfSharesIssuedInTransactionPerDay" name="SaleOfStockNumberOfSharesIssuedInTransactionPerDay" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_SaleOfStockIncreaseDecreaseInNumberOfSharesIssuedInTransactionPerDay" name="SaleOfStockIncreaseDecreaseInNumberOfSharesIssuedInTransactionPerDay" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_SaleOfStockMaximumNumberOfSharesIssuedInTransactionPerDay" name="SaleOfStockMaximumNumberOfSharesIssuedInTransactionPerDay" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_AgreementTerm" name="AgreementTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_PurchasePriceDescription" name="PurchasePriceDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_SaleOfStockPercentageOfNumberOfSharesIssuedDuringPeriodInTransaction" name="SaleOfStockPercentageOfNumberOfSharesIssuedDuringPeriodInTransaction" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_CommonStockTradedDuringPeriodSharesPercentage" name="CommonStockTradedDuringPeriodSharesPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_SaleOfStockPricePerSharePercentageOfVolumeWeightedAveragePrice" name="SaleOfStockPricePerSharePercentageOfVolumeWeightedAveragePrice" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_OwnershipPercentageByNonControllingOwners" name="OwnershipPercentageByNonControllingOwners" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="vtvt_MaximumNumberOfSharesToBeIssuedAsPercentageOfOutstanding" name="MaximumNumberOfSharesToBeIssuedAsPercentageOfOutstanding" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_MaximumNumberOfSharesToBeIssued" name="MaximumNumberOfSharesToBeIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="vtvt_LetterAgreementWarrantsMember" name="LetterAgreementWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_PeriodUsedToDetermineExchangeValueBasedOnWeightedAveragePriceOfClassCommonStock" name="PeriodUsedToDetermineExchangeValueBasedOnWeightedAveragePriceOfClassCommonStock" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_RedeemableNonControllingInterestExchangeAgreementStockConversionRatio" name="RedeemableNonControllingInterestExchangeAgreementStockConversionRatio" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_ExchangeOfRedeemableNonControllingInterestToClassACommonStockMember" name="ExchangeOfRedeemableNonControllingInterestToClassACommonStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_RedeemableNoncontrollingInterestTemporaryEquityRedemptionValue" name="RedeemableNoncontrollingInterestTemporaryEquityRedemptionValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_OwnershipPercentageOfMajorityOwner" name="OwnershipPercentageOfMajorityOwner" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_CommitmentContingencyAndRelatedPartyTransactionsAbstract" name="CommitmentContingencyAndRelatedPartyTransactionsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_MacAndrewsAndForbesIncorporatedMember" name="MacAndrewsAndForbesIncorporatedMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_LetterAgreementsExpirationDate" name="LetterAgreementsExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_ClassOfWarrantOrRightWarrantsExpirationDate" name="ClassOfWarrantOrRightWarrantsExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_ClassOfWarrantOrRightNumberOfSharesIssuedForWarrantsOrRights" name="ClassOfWarrantOrRightNumberOfSharesIssuedForWarrantsOrRights" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_ClassOfWarrantOrRightNumberOfRemainingSharesToBeIssued" name="ClassOfWarrantOrRightNumberOfRemainingSharesToBeIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="vtvt_TwoThousandAndSeventeenLetterAgreementMember" name="TwoThousandAndSeventeenLetterAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_TwoThousandAndEighteenLetterAgreementMember" name="TwoThousandAndEighteenLetterAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_TwoThousandAndNineteenLetterAgreementMember" name="TwoThousandAndNineteenLetterAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_PercentageOfAmountOfCashSavings" name="PercentageOfAmountOfCashSavings" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_TaxReceivableAgreementDescription" name="TaxReceivableAgreementDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_CompensationAndEmployeeBenefitPlansAbstract" name="CompensationAndEmployeeBenefitPlansAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_IncomeTaxesLineItems" name="IncomeTaxesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_IncomeTaxesTable" name="IncomeTaxesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_MFTTPHoldingsLLCMember" name="MFTTPHoldingsLLCMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_ExpireIn2035To2037Member" name="ExpireIn2035To2037Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_IndefiniteMember" name="IndefiniteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_ExpireIn2035To2039Member" name="ExpireIn2035To2039Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_IncomeTaxReconciliationPartnershipIncomeFederalNotSubjectToTax" name="IncomeTaxReconciliationPartnershipIncomeFederalNotSubjectToTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_IncomeTaxReconciliationForeignWithholdingTax" name="IncomeTaxReconciliationForeignWithholdingTax" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_OperatingLossCarryforwardsExpiringDate" name="OperatingLossCarryforwardsExpiringDate" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_MaximumPercentageOfTaxableIncomeLimitedToOffsetByNetOperatingLossCarryforwads" name="MaximumPercentageOfTaxableIncomeLimitedToOffsetByNetOperatingLossCarryforwads" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="vtvt_AccrualAndRelatedExpenseRelatedToSeveranceBenefits" name="AccrualAndRelatedExpenseRelatedToSeveranceBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_AccrualsRecordedForSeveranceBenefits" name="AccrualsRecordedForSeveranceBenefits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_DeemedDistributionToRelatedParty" name="DeemedDistributionToRelatedParty" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_NetIncomeLossAvailableToCommonStockholdersBasicAndDiluted" name="NetIncomeLossAvailableToCommonStockholdersBasicAndDiluted" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_ScheduleOfEarningsPerShareLineItems" name="ScheduleOfEarningsPerShareLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_ScheduleOfEarningsPerShareTable" name="ScheduleOfEarningsPerShareTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_EmployeeStockOptionsUnderLetterAgreementMember" name="EmployeeStockOptionsUnderLetterAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems" name="FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable" name="FairValueOfAssetsAndLiabilitiesMeasuredOnRecurringBasisTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_WarrantLiabilityRelatedPartyMember" name="WarrantLiabilityRelatedPartyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisWarrantLiabilityIssuance" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisWarrantLiabilityIssuance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisWarrantLiabilitySales" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisWarrantLiabilitySales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisWarrantLiability" name="FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisWarrantLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="vtvt_TwoThousandNineteenAndTwoThousandTwentyAgreementWarrantsMember" name="TwoThousandNineteenAndTwoThousandTwentyAgreementWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="vtvt_DevelopmentAndRegulatoryMilestonePayments" name="DevelopmentAndRegulatoryMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="vtvt_FirstHuadongAmendmentMember" name="FirstHuadongAmendmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
