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vTv to Host Key Opinion Leader Event to Discuss the Current State of Clinical Development in Alzheimer’s Disease
The event will feature two speakers, each with extensive experience in the clinical development in Alzheimer’s:
Howard Fillit, founding executive director and chief scientific officer of Alzheimer’s Drug Discovery Foundation, clinical professor of geriatric medicine, palliative care, and neuroscience at Mt. Sinai School of Medicine
Mary Sano, associate dean for clinical research, professor of Psychiatry, founding member and director of the Alzheimer’s Disease Research Centerat Mt. Sinai School of Medicine
In addition to the presentations,
A live webcast of the event will be available on the Investor page of vTv’s website at www.vtvtherapeutics.com. The archived version of the webcast will be available for replay on the Events & Presentations section of the Investors page of vTv Therapeutics’ website for 90 days following the event.
vTv discovered and developed azeliragon using its proprietary drug discovery platform TTP Translational Technology®. A broad range of human pathologic and experimental biologic investigation suggests that RAGE activation contributes to the pathogenesis of Alzheimer’s disease. Sustained Amyloid-β interactions with RAGE at the blood-brain barrier (BBB) and in neuronal and microglial cells, play potentially major roles in amyloid plaque formation, neuroinflammation and chronic neural dysfunction – all hallmarks of Alzheimer’s disease. Azeliragon, also known as TTP488, is a novel orally active small-molecule antagonist of RAGE.
STEADFAST, two identical randomized, double-blind, placebo-controlled
Phase 3 trials, is investigating the safety and efficacy of azeliragon
as a potential treatment to slow the decline in cognition and functional
activities for patients with mild Alzheimer’s disease. The 18-month
trial targeted enrollment of 800 patients (400 each for Part A and B).
Part A enrolled patients in
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our Annual Report on Form 10-K and our other filings with the