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vTv Therapeutics Announces Licensing Agreement for Novel Nrf2 Activator to Anteris Bio
HPP971 is vTv’s most advanced oral, small molecule activator of the Nrf2 pathway (nuclear factor erythroid 2-related factor 2) within its portfolio of promising Nrf2 compounds. HPP971 has completed two phase 1 studies to date. Under the terms of the agreement, Anteris will pay vTv an upfront payment of
“The Nrf2 pathway is a promising, novel target for combating many diseases related to oxidative stress, including renal disease,” said
Chronic kidney disease (CKD) is one of the most significant global health challenges and a leading cause of mortality, both directly and as a key risk factor for cardiovascular disease. Globally, it is estimated that nearly 700 million individuals suffer from CKD, and CKD is directly responsible for over 1 million deaths annually. Clear unmet medical need exists in renal disease as therapies have traditionally revolved around treatment of symptoms (e.g. hypertension, renal failure). HPP971, to be renamed ANT-401, is a small molecule activator of Nrf2, a mechanism which has disease modifying potential across multiple etiologies of renal disease. Nrf2 is a transcription factor required for the expression of many antioxidant genes regulated by the ARE promoter sequence. ANT-401 activates Nrf2 through the inhibition of Bach1, a transcription repressor that prevents Nrf2 activity in the nucleus.
vTv will continue to explore further internal development and partnership opportunities for the remaining molecules in its portfolio of Nrf2 activators.
About Aditum Bio
Aditum Bio is committed to improving public health by accelerating R&D in disease areas with both large and more targeted patient populations, where medical innovation can have a huge impact. Aditum Bio focuses on basic mechanisms of disease, in-licenses promising drug candidates directed at such pathophysiologies, and spins-out individual companies dedicated to bringing each candidate through Phase II clinical trials. In partnership with TrialSpark, a technology driven research company that can complete clinical trials faster and at a lower cost than traditional trials, Aditum Bio uses data, software and technology to help bring innovative medicines through the clinical trial phase more quickly and with lower costs than traditional pharmaceutical companies.
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Source: vTv Therapeutics Inc.