-Workforce reduction of 65%
-Prioritization of lead program TTP399, a potentially transformative treatment for the reduction of hypoglycemic episodes in type 1 diabetes patients
TTP399 is a novel, oral, liver-selective glucokinase activator that showed ~40% reduction in hypoglycemic episodes compared to placebo in its Phase 2 study and was granted Breakthrough Therapy Designation by the FDA. In October, the Company announced positive results of its mechanistic study showing no increased risk of ketoacidosis. Additionally, zero hypoglycemic episodes occurred in the TTP399 arm while four occurred on placebo.
Type 1 Diabetes (T1D) is an autoimmune disease with no cure affecting over 1.6 million people today in
Due to its shift in strategic focus, the Company:
“It is always difficult to restructure but this allows us to focus on TTP399 and our future growth,” said
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Source: vTv Therapeutics Inc.