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vTv Therapeutics Announces Results of Multiple Ascending Dose Study and Development Plan for HPP737, an Oral PDE4 Inhibitor for the Treatment of Psoriasis
HPP737 exhibited favorable safety and tolerability profile, with no dose limiting gastrointestinal side effects
Results build on data from previous multiple ascending dose study and support advancement of HPP737 into Phase 2 in moderate to severe psoriasis.
Successful pre-IND meeting with
With these results, vTv held a successful pre-IND meeting with the
“We are pleased that the study accomplished its objectives by confirming the anticipated favorable safety and tolerability profile of HPP737, particularly the absence of dose limiting gastrointestinal adverse events, at substantially higher concentrations than previously tested,” said Steve Holcombe, chief executive officer, vTv Therapeutics. “An oral, once-daily PDE4 inhibitor with robust efficacy, absent adverse events of gastrointestinal distress, would be a significant benefit for patients with psoriasis. With FDA’s feedback on our trial design we look forward to submitting the IND and beginning the Phase 2 trial in early 2022.”
In addition to the Company’s planned Phase 2 study in moderate to severe psoriasis, Newsoara Biopharma, the Company’s strategic partner in
HPP737 is a novel, potent, orally administered PDE4 inhibitor discovered by
Psoriasis is a chronic autoimmune inflammatory disease that impacts the skin and joints due to an imbalance of inflammatory cytokines. This results in the development of raised, red, silvery scale plaques on the skin (i.e. plaque psoriasis, psoriasis vulgaris) that has both medical implications and an impact on a patient’s quality of life. While the specific trigger for this inflammatory imbalance is unknown, psoriasis may be caused by autoimmunity and genetic predisposition. Events such as trauma to the skin, stress, illness or infection that triggers the immune system, obesity, and weather have all been identified as contributing factors.
About vTv Therapeutics
vTv Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on developing oral, small molecule drug candidates. vTv has a pipeline of clinical drug candidates led by programs for the treatment of type 1 diabetes and psoriasis. vTv’s development partners are pursuing additional indications in type 2 diabetes, chronic obstructive pulmonary disease, renal disease, primary mitochondrial myopathy, and pancreatic cancer. For more information, please visit www.vtvtherapeutics.com or follow us on Twitter: @vTvTherapeutics.
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Source: vTv Therapeutics Inc.