As Part of
“It is very exciting to launch this effort to potentially develop a
completely novel pill therapy for type 1 diabetes,” said Dr. John Buse,
director of the North Carolina Translational and Clinical Sciences
Institute and of the Diabetes Center at the University of
TTP399 is an orally available glucokinase enzyme (GK) activator that is designed to target GK activation only in the liver for superior glucose control. In the liver, GK is a key regulator of glucose metabolism, and its activation has been shown to increase glucose utilization, which in turn lowers blood glucose. In a six-month Phase 2b clinical trial of TTP399 in patients with type 2 diabetes, TTP399 demonstrated a statistically significant reduction in HbA1c levels in all TTP399 dose groups compared with placebo. TTP399 was also found to be well-tolerated without increased incidences of hypoglycemia and hyperlipidemia compared to placebo.
“We’ve gathered promising data in our clinical studies in type 2
diabetes and are eager to explore the potential of TTP399 as an
insulin-adjunctive therapy in type 1 diabetes,” said
About Type 1 Diabetes
Type 1 diabetes (T1D) is an autoimmune disease in which a person’s pancreas stops producing insulin, a hormone that enables people to get energy from food. It occurs when the body’s immune system attacks and destroys the insulin-producing cells in the pancreas, called beta cells. While its causes are not yet entirely understood, scientists believe that both genetic factors and environmental triggers are involved. Its onset has nothing to do with diet or lifestyle. There is nothing you can do to prevent T1D, and—at present—nothing you can do to cure it.
About
The Company’s drug candidates were discovered with its high-throughput drug discovery platform, TTP Translational Technology®, which translates the functional modulation of human proteins into safe and effective medicines. For further company information, visit www.vtvtherapeutics.com.
About JDRF
JDRF is the leading global organization funding type 1 diabetes (T1D)
research. Our mission is to accelerate life-changing breakthroughs to
cure, prevent and treat T1D and its complications. To accomplish this,
JDRF has invested more than
Forward-Looking Statements
This release contains forward-looking statements, which involve risks
and uncertainties. These forward-looking statements can be identified by
the use of forward-looking terminology, including the terms
“anticipate,” “believe,” “could,” “estimate,” “expect,” “intend,” “may,”
“plan,” “potential,” “predict,” “project,” “should,” “target,” “will,”
“would” and, in each case, their negative or other various or comparable
terminology. All statements other than statements of historical facts
contained in this release, including statements regarding the timing of
our clinical trials, our strategy, future operations, future financial
position, future revenue, projected costs, prospects, plans, objectives
of management and expected market growth are forward-looking statements.
These statements involve known and unknown risks, uncertainties and
other important factors that may cause our actual results, performance
or achievements to be materially different from any future results,
performance or achievements expressed or implied by the forward-looking
statements. Important factors that could cause our results to vary from
expectations include those described under the heading “Risk Factors” in
our Annual Report on Form 10-K and our other filings with the
View source version on businesswire.com: http://www.businesswire.com/news/home/20171108006585/en/
Source:
Investors:
vTv Therapeutics Inc.
Mike Biega,
617-221-9660
IR@vtvtherapeutics.com
or
Media:
Pure
Communications Inc.
Katie Engleman, 910-509-3977
Katie@purecommunications.com